2017
Predictors of aggression in 3.322 patients with affective disorders and schizophrenia spectrum disorders evaluated in an emergency department setting
Blanco E, Duque L, Rachamallu V, Yuen E, Kane J, Gallego J. Predictors of aggression in 3.322 patients with affective disorders and schizophrenia spectrum disorders evaluated in an emergency department setting. Schizophrenia Research 2017, 195: 136-141. PMID: 29102223, PMCID: PMC6510030, DOI: 10.1016/j.schres.2017.10.002.Peer-Reviewed Original Research
2015
Predictors of suicide attempts in 3.322 patients with affective disorders and schizophrenia spectrum disorders
Gallego JA, Rachamallu V, Yuen EY, Fink S, Duque LM, Kane JM. Predictors of suicide attempts in 3.322 patients with affective disorders and schizophrenia spectrum disorders. Psychiatry Research 2015, 228: 791-796. PMID: 26077849, PMCID: PMC4532595, DOI: 10.1016/j.psychres.2015.05.024.Peer-Reviewed Original ResearchConceptsSuicidal attemptsSchizophrenia spectrum disordersAffective disordersChildren/adolescent groupLong Island Jewish Medical CenterSuicide attemptsCurrent suicidal attemptsComprehensive psychiatric evaluationZucker Hillside HospitalPrevious suicidal attemptsMultivariate regression analysisSchizophrenia spectrum diagnosisPotential suicidal behaviorElectronic health recordsPsychiatric followEmergency departmentRisk factorsElderly groupPsychiatric hospitalizationMedical CenterHigher oddsSpectrum disorderPsychiatric evaluationPsychiatric patientsHillside Hospital
2011
The Novel Antipsychotic Drug Lurasidone Enhances N-Methyl-d-aspartate Receptor-Mediated Synaptic Responses
Yuen EY, Li X, Wei J, Horiguchi M, Meltzer HY, Yan Z. The Novel Antipsychotic Drug Lurasidone Enhances N-Methyl-d-aspartate Receptor-Mediated Synaptic Responses. Molecular Pharmacology 2011, 81: 113-119. PMID: 22072817, PMCID: PMC3263951, DOI: 10.1124/mol.111.076141.Peer-Reviewed Original ResearchConceptsAtypical antipsychotic drugsEffect of lurasidoneSynaptic responsesVivo administrationN-methyl-D-aspartate (NMDA) receptor hypofunctionShort-term administrationCortical pyramidal neuronsAtypical APDsReceptor antagonist haloperidolAtypical APD clozapineKey molecular targetsSubchronic administrationPyramidal neuronsReceptor hypofunctionReceptor antagonismReceptor antagonistAntagonist haloperidolNMDAR responsesNMDAR synaptic functionAntipsychotic drugsNR2B subunitSerotonin 5Noncompetitive antagonistLurasidoneCognitive impairment
2010
Homeostatic regulation of glutamatergic transmission by dopamine D4 receptors
Yuen EY, Zhong P, Yan Z. Homeostatic regulation of glutamatergic transmission by dopamine D4 receptors. Proceedings Of The National Academy Of Sciences Of The United States Of America 2010, 107: 22308-22313. PMID: 21135234, PMCID: PMC3009820, DOI: 10.1073/pnas.1010025108.Peer-Reviewed Original ResearchConceptsSynaptic transmissionPrefrontal cortex pyramidal neuronsCortex pyramidal neuronsExcitatory synaptic transmissionAttention deficit hyperactivity disorderRole of dopamineDopamine D4 receptorGlutamatergic transmissionPyramidal neuronsCortical excitabilityProfound depressionMental disordersSynaptic functionBrain regionsD4 receptorsSynaptic factorsAMPAR traffickingPrefrontal cortexDistinct signaling pathwaysHyperactivity disorderCaMKII activityBidirectional regulationHomeostatic regulationReceptorsSignaling pathways