2013
Estrogen protects against the detrimental effects of repeated stress on glutamatergic transmission and cognition
Wei J, Yuen EY, Liu W, Li X, Zhong P, Karatsoreos IN, McEwen BS, Yan Z. Estrogen protects against the detrimental effects of repeated stress on glutamatergic transmission and cognition. Molecular Psychiatry 2013, 19: 588-598. PMID: 23835908, DOI: 10.1038/mp.2013.83.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAromataseAromatase InhibitorsCognitionEstradiolEstrogensFemaleGlutamic AcidMaleMemory DisordersPrefrontal CortexPyramidal CellsRats, Sprague-DawleyReceptors, EstrogenReceptors, GlutamateRecognition, PsychologyRNA, MessengerSex CharacteristicsStress, PsychologicalSynaptic TransmissionConceptsTemporal order recognition memoryGlutamatergic transmissionPrefrontal cortexStressed malesPFC of femalesNormal glutamatergic transmissionGlutamate receptor surface expressionPFC pyramidal neuronsYoung female ratsAdministration of estradiolLevels of aromatasePFC-dependent cognitionReceptor surface expressionBiosynthesis of estrogensEstrogen protectsPyramidal neuronsGlutamatergic deficitsRestraint stressFemale ratsEstrogen receptorGlutamate receptorsDetrimental effectsDimorphic effectsMemory impairmentStressed females
2012
Repeated Stress Causes Cognitive Impairment by Suppressing Glutamate Receptor Expression and Function in Prefrontal Cortex
Yuen EY, Wei J, Liu W, Zhong P, Li X, Yan Z. Repeated Stress Causes Cognitive Impairment by Suppressing Glutamate Receptor Expression and Function in Prefrontal Cortex. Neuron 2012, 73: 962-977. PMID: 22405206, PMCID: PMC3302010, DOI: 10.1016/j.neuron.2011.12.033.Peer-Reviewed Original ResearchMeSH Keywords2-Amino-5-phosphonovalerate6-Cyano-7-nitroquinoxaline-2,3-dioneAnalysis of VarianceAnimalsBicucullineCognition DisordersDisease Models, AnimalEndosomal Sorting Complexes Required for TransportExcitatory Amino Acid AntagonistsExcitatory Postsynaptic PotentialsF-Box ProteinsGABA-A Receptor AntagonistsImmunoprecipitationIn Vitro TechniquesMaleNedd4 Ubiquitin Protein LigasesNeuropsychological TestsPrefrontal CortexPyramidal CellsRatsRats, Sprague-DawleyReceptors, GlutamateRecognition, PsychologyRestraint, PhysicalRNA, Small InterferingStress, PsychologicalUbiquitin-Protein LigasesConceptsGlutamate receptor expressionPrefrontal cortexRepeated stressReceptor expressionRecognition memoryCognitive processesTemporal order recognition memoryPFC pyramidal neuronsStress-related mental disordersJuvenile male ratsGlutamatergic responsesGlutamatergic transmissionPyramidal neuronsMale ratsSynaptic transmissionStressed animalsInhibition of proteasomeMaladaptive changesGlucocorticoid receptorCognitive impairmentNR1 subunitMental disordersChronic stressUbiquitin/proteasome-mediated degradationReceptor turnover