1992
A Controlled Trial of Antimicrobial Prophylaxis for Lyme Disease after Deer-Tick Bites
Shapiro E, Gerber M, Holabird N, Berg A, Feder H, Bell G, Rys P, Persing D. A Controlled Trial of Antimicrobial Prophylaxis for Lyme Disease after Deer-Tick Bites. New England Journal Of Medicine 1992, 327: 1769-1773. PMID: 1435930, DOI: 10.1056/nejm199212173272501.Peer-Reviewed Original ResearchMeSH KeywordsAdultAmoxicillinAnimalsAntibodies, BacterialBites and StingsChildDouble-Blind MethodFemaleFollow-Up StudiesHumansLyme DiseaseMaleRiskTicksConceptsDeer tick biteRisk of infectionProphylactic antimicrobial treatmentLyme diseaseB. burgdorferiAntimicrobial treatmentDeer ticksPlacebo-controlled trialPlacebo-treated subjectsCare of personsAsymptomatic seroconversionAntimicrobial prophylaxisErythema migransClinical manifestationsPolymerase chain reactionLate manifestationPlaceboDiseaseSerum samplesInfectionBorrelia burgdorferiBiteChain reactionAmoxicillinBurgdorferi
1985
Oral trimethoprim/sulfamethoxazole for prevention of bacterial infection during the induction phase of cancer chemotherapy in children.
Kovatch A, Wald E, Albo V, Prin W, Orlando S, Wollman M, Phebus C, Shapiro E. Oral trimethoprim/sulfamethoxazole for prevention of bacterial infection during the induction phase of cancer chemotherapy in children. Pediatrics 1985, 76: 754-60. PMID: 3903647, DOI: 10.1542/peds.76.5.754.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAnti-Infective AgentsAntineoplastic AgentsBacterial InfectionsChildChild, PreschoolClinical Trials as TopicDouble-Blind MethodDrug CombinationsDrug Therapy, CombinationFemaleHumansInfantLeukemia, LymphoidLeukemia, Myeloid, AcuteMaleMicrobial Sensitivity TestsRandom AllocationSulfamethoxazoleTrimethoprimTrimethoprim, Sulfamethoxazole Drug CombinationConceptsTrimethoprim/sulfamethoxazoleOral trimethoprim/sulfamethoxazoleTrimethoprim/sulfamethoxazole groupFebrile episodesBacterial infectionsAcute leukemiaSolid tumorsPlacebo-controlled studyFrequency of bacteremiaInduction phaseInvasive fungal infectionsLife-table analysisGranulocytopenic childrenInduction chemotherapyReceiving placeboIntensive chemotherapyPlacebo groupOral thrushMean durationChemotherapyBacteremiaFungal infectionsOverall riskCancer chemotherapyInfection
1984
Resolving the Pneumococcal Vaccine Controversy: Are There Alternatives to Randomized Clinical Trials?
Clemens J, Shapiro E. Resolving the Pneumococcal Vaccine Controversy: Are There Alternatives to Randomized Clinical Trials? Clinical Infectious Diseases 1984, 6: 589-600. PMID: 6390636, DOI: 10.1093/clinids/6.5.589.Peer-Reviewed Original Research