Ethan Foscue
Research AssociateAbout
Titles
Research Associate
Education & Training
- BA
- Skidmore College (2010)
Research
Research at a Glance
Yale Co-Authors
Frequent collaborators of Ethan Foscue's published research.
Publications Timeline
A big-picture view of Ethan Foscue's research output by year.
Jian Xu, PhD
Kristen Brennand, PhD
Paul Lombroso, MD
Ralph DiLeone, PhD
Stephanie Groman, PhD
TuKiet Lam, PhD, BS
8Publications
312Citations
Publications
2020
Medial Nucleus Accumbens Projections to the Ventral Tegmental Area Control Food Consumption
Bond CW, Trinko R, Foscue E, Furman K, Groman SM, Taylor JR, DiLeone RJ. Medial Nucleus Accumbens Projections to the Ventral Tegmental Area Control Food Consumption. Journal Of Neuroscience 2020, 40: 4727-4738. PMID: 32354856, PMCID: PMC7294796, DOI: 10.1523/jneurosci.3054-18.2020.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsControl food intakeNAc projectionsFood intakeAccumbens projectionsLateral hypothalamusMesolimbic circuitsFood consumptionNucleus accumbens projectionsFood-seeking behaviorNAC controlVTA pathwayInhibitory projectionsMale miceNAc shellOptogenetic activationFiber photometryOptogenetic inhibitionPermissive rolePharmacological studiesDrug rewardVTAConsummatory behaviorIntakeAdaptive inhibitionNeural activity
2016
Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models
Xu J, Hartley BJ, Kurup P, Phillips A, Topol A, Xu M, Ononenyi C, Foscue E, Ho SM, Baguley TD, Carty N, Barros CS, Müller U, Gupta S, Gochman P, Rapoport J, Ellman JA, Pittenger C, Aronow B, Nairn AC, Nestor MW, Lombroso PJ, Brennand KJ. Inhibition of STEP61 ameliorates deficits in mouse and hiPSC-based schizophrenia models. Molecular Psychiatry 2016, 23: 271-281. PMID: 27752082, PMCID: PMC5395367, DOI: 10.1038/mp.2016.163.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsBrain-specific tyrosine phosphataseDephosphorylation of GluN2BExtracellular signal-regulated kinase 1/2Signal-regulated kinase 1/2Glutamate receptor internalizationPluripotent stem cellsKnockout mouse modelTyrosine phosphataseMouse modelKinase 1/2Receptor internalizationImportant regulatorGenetic reductionLoss of NMDARsStem cellsN-methyl DPharmacological inhibitionProtein levelsSynaptic functionSTEP61Patient cohortForebrain neuronsBehavioral deficitsExcitatory neuronsSchizophrenia model
2015
Inhibition of the tyrosine phosphatase STEP61 restores BDNF expression and reverses motor and cognitive deficits in phencyclidine-treated mice
Xu J, Kurup P, Baguley TD, Foscue E, Ellman JA, Nairn AC, Lombroso PJ. Inhibition of the tyrosine phosphatase STEP61 restores BDNF expression and reverses motor and cognitive deficits in phencyclidine-treated mice. Cellular And Molecular Life Sciences 2015, 73: 1503-1514. PMID: 26450419, PMCID: PMC4801664, DOI: 10.1007/s00018-015-2057-1.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAnimalsBenzothiepinsBrain-Derived Neurotrophic FactorCells, CulturedCognition DisordersCREB-Binding ProteinDown-RegulationMaleMiceMice, Inbred C57BLMitogen-Activated Protein Kinase 1Mitogen-Activated Protein Kinase 3Motor ActivityNeuronsPhencyclidinePhosphorylationProtein Tyrosine PhosphatasesReceptors, N-Methyl-D-AspartateRNA InterferenceUbiquitinationConceptsBrain-derived neurotrophic factorBDNF expressionProtein tyrosine Phosphatase 61Cognitive deficitsPCP-induced reductionPCP-treated micePhencyclidine-treated micePCP-induced increasePCP-induced hyperlocomotionTyrosine phosphatase STEP61STEP61 levelsBDNF transcriptionNeurotrophic factorNMDAR antagonistsCortical culturesCortical neuronsCNS disordersSynaptic strengtheningPsychotic episodeRodent modelsBrain disordersPharmacologic inhibitionSTEP61SchizophreniaCognitive functioningStriatal‐enriched protein tyrosine phosphatase regulates the PTPα/Fyn signaling pathway
Xu J, Kurup P, Foscue E, Lombroso PJ. Striatal‐enriched protein tyrosine phosphatase regulates the PTPα/Fyn signaling pathway. Journal Of Neurochemistry 2015, 134: 629-641. PMID: 25951993, PMCID: PMC4516628, DOI: 10.1111/jnc.13160.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsConceptsProtein tyrosine phosphataseProtein kinase ARegulation of FynTyrosine phosphataseReceptor-type protein tyrosine phosphatase alphaProtein tyrosine phosphatase alphaStriatal-enriched protein tyrosine phosphataseRegulatory tyrosine residuesActivation of FynTyrosine kinase FynRegulatory tyrosineProtein tyrosinePTPαKinase FynSynaptic membranesKinase ATyrosine residuesFyn activityFynNovel substratePrimary neuronal culturesSTEP61Synergistic regulationMolecular techniquesNovel mechanism
2014
Inhibitor of the Tyrosine Phosphatase STEP Reverses Cognitive Deficits in a Mouse Model of Alzheimer's Disease
Xu J, Chatterjee M, Baguley TD, Brouillette J, Kurup P, Ghosh D, Kanyo J, Zhang Y, Seyb K, Ononenyi C, Foscue E, Anderson GM, Gresack J, Cuny GD, Glicksman MA, Greengard P, Lam TT, Tautz L, Nairn AC, Ellman JA, Lombroso PJ. Inhibitor of the Tyrosine Phosphatase STEP Reverses Cognitive Deficits in a Mouse Model of Alzheimer's Disease. PLOS Biology 2014, 12: e1001923. PMID: 25093460, PMCID: PMC4122355, DOI: 10.1371/journal.pbio.1001923.Peer-Reviewed Original ResearchCitationsAltmetricMeSH Keywords and ConceptsMeSH KeywordsAlzheimer DiseaseAmino Acid SequenceAnimalsBenzothiepinsCatalytic DomainCell DeathCerebral CortexCognition DisordersCysteineDisease Models, AnimalEnzyme InhibitorsHigh-Throughput Screening AssaysHumansMaleMice, Inbred C57BLMice, KnockoutMolecular Sequence DataNeuronsPhosphorylationPhosphotyrosineProtein Tyrosine Phosphatases, Non-ReceptorSubstrate SpecificityConceptsInhibitors of stepsSpecificity of inhibitorsIsoxazolepropionic acid receptor (AMPAR) traffickingCatalytic cysteinePTP inhibitorsTyrosine phosphataseTyrosine phosphorylationSecondary assaysSTEP KO miceReceptor traffickingFirst large-scale effortN-methyl-D-aspartate receptorsPyk2 activitySTEP inhibitorLarge-scale effortsNovel therapeutic targetSynaptic functionAlzheimer's diseaseNeurodegenerative disordersCortical cellsTherapeutic targetERK1/2Specificity experimentsPhosphataseInhibitors
2012
Characterization of a semi-rapid method for assessing delay discounting in rodents
Foscue E, Wood K, Schramm-Sapyta N. Characterization of a semi-rapid method for assessing delay discounting in rodents. Pharmacology Biochemistry And Behavior 2012, 101: 187-192. PMID: 22266769, PMCID: PMC3288622, DOI: 10.1016/j.pbb.2012.01.006.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsImportant disease processesChronic treatmentRodent modelsPsychiatric disordersDisease processDaily sessionsStable response patternsDrug addictionUnderlying mechanismSession learningOperant responseFuture studiesResponse patternsStable baselineExtended trainingCompulsive gamblingSubsequent daily sessionsObesityBaselineMonthsCocaine
2011
Individual differences in cocaine conditioned taste aversion are developmentally stable and independent of locomotor effects of cocaine
Drescher C, Foscue E, Kuhn C, Schramm-Sapyta N. Individual differences in cocaine conditioned taste aversion are developmentally stable and independent of locomotor effects of cocaine. Developmental Cognitive Neuroscience 2011, 1: 600-605. PMID: 21927632, PMCID: PMC3173773, DOI: 10.1016/j.dcn.2011.05.004.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsIndividual differencesApproach/avoidance behaviorComplex motivational statesApproach/avoidanceCocaine-induced locomotor effectsAversive effectsTaste aversion taskInterindividual differencesBrain cocaine levelsMotivational stateMotivational effectsDrugs of abuseAvoidance behaviorNeurological processesLocomotor effectsTaste aversionTaskAdulthoodDevelopmental variationAbuseCocaineAdolescenceAdolescentsAvoidanceCocaine levels
2010
Aversive Effects of Ethanol in Adolescent Versus Adult Rats: Potential Causes and Implication for Future Drinking
Schramm‐Sapyta N, DiFeliceantonio AG, Foscue E, Glowacz S, Haseeb N, Wang N, Zhou C, Kuhn CM. Aversive Effects of Ethanol in Adolescent Versus Adult Rats: Potential Causes and Implication for Future Drinking. Alcohol Clinical And Experimental Research 2010, 34: 2061-2069. PMID: 20860614, PMCID: PMC2988872, DOI: 10.1111/j.1530-0277.2010.01302.x.Peer-Reviewed Original ResearchCitationsMeSH Keywords and ConceptsConceptsAversive effectsAdolescents Versus AdultsProblem drinking behaviorDrug seeking behaviorBlood ethanol concentrationTaste aversionFuture drinkingAdolescent ratsAge differencesDrugs of abuseEthanol CTADrug takingDrinking behaviorAdolescentsPhysiologic effectsAdult ratsTeenage yearsIndividual variationRodent studiesAbuseAdultsSeeking behaviourDrug intakeEpidemiological evidenceSedative effects