2017
Dimethyl fumarate induces changes in B- and T-lymphocyte function independent of the effects on absolute lymphocyte count
Longbrake EE, Cantoni C, Chahin S, Cignarella F, Cross AH, Piccio L. Dimethyl fumarate induces changes in B- and T-lymphocyte function independent of the effects on absolute lymphocyte count. Multiple Sclerosis Journal 2017, 24: 728-738. PMID: 28480794, PMCID: PMC5665729, DOI: 10.1177/1352458517707069.Peer-Reviewed Original ResearchConceptsAbsolute lymphocyte countDMF-treated patientsPeripheral blood mononuclear cellsDimethyl fumarateLymphocyte countPeptide stimulationLow absolute lymphocyte countFollicular T helper cellsDMF-induced lymphopeniaInvariant T (MAIT) cellsPro-inflammatory cytokinesT-cell phenotypeBlood mononuclear cellsT cell productionT helper cellsT lymphocyte functionMemory B cellsActivation-induced cell deathMultiparametric flow cytometryUntreated patientsMultiple sclerosisMononuclear cellsHealthy controlsT cellsT lymphocytes
2008
Remote activation of microglia and pro-inflammatory cytokines predict the onset and severity of below-level neuropathic pain after spinal cord injury in rats
Detloff MR, Fisher LC, McGaughy V, Longbrake EE, Popovich PG, Basso DM. Remote activation of microglia and pro-inflammatory cytokines predict the onset and severity of below-level neuropathic pain after spinal cord injury in rats. Experimental Neurology 2008, 212: 337-347. PMID: 18511041, PMCID: PMC2600773, DOI: 10.1016/j.expneurol.2008.04.009.Peer-Reviewed Original ResearchConceptsPeripheral nerve injuryL5 dorsal hornRemote microglial activationLevel allodyniaPro-inflammatory cytokinesMicroglial activationNeuropathic painNerve injuryDorsal hornLevel painPro-inflammatory cytokine productionActivator of microgliaLevel neuropathic painRobust microglial activationChronic time pointsSpinal cord injuryLevel of injuryAllodynic ratsChronic allodyniaModerate SCISupraspinal centersCord injuryCytokine productionIL-6IL-1beta