2024
A Noncanonical CD56dimCD16dim/- NK Cell Subset Indicative of Prior Cytotoxic Activity Is Elevated in Patients with Autoantibody-Mediated Neurologic Diseases.
Yandamuri S, Filipek B, Lele N, Cohen I, Bennett J, Nowak R, Sotirchos E, Longbrake E, Mace E, O'Connor K. A Noncanonical CD56dimCD16dim/- NK Cell Subset Indicative of Prior Cytotoxic Activity Is Elevated in Patients with Autoantibody-Mediated Neurologic Diseases. The Journal Of Immunology 2024, 212: 785-800. PMID: 38251887, PMCID: PMC10932911, DOI: 10.4049/jimmunol.2300015.Peer-Reviewed Original ResearchConceptsNeuromyelitis optica spectrum disorderAb-dependent cellular cytotoxicityNK cellsMyasthenia gravisMG patientsInduced Ab-dependent cellular cytotoxicityNK cell-mediated effector functionsPeripheral blood immune cell populationsCell-mediated effector functionsNeuromyelitis optica spectrum disorder patientsBlood immune cell populationsAb-dependent cellular cytotoxicity activityNK marker CD56NK cell markersHLA-DR expressionNK cell subsetsExpression of perforinImmune cell populationsAutoimmune myasthenia gravisElevated disease burdenHLA-DRCell subsetsCellular cytotoxicityChemokine receptorsMultiparameter immunophenotyping
2011
Deficient CX3CR1 Signaling Promotes Recovery after Mouse Spinal Cord Injury by Limiting the Recruitment and Activation of Ly6Clo/iNOS+ Macrophages
Donnelly DJ, Longbrake EE, Shawler TM, Kigerl KA, Lai W, Tovar CA, Ransohoff RM, Popovich PG. Deficient CX3CR1 Signaling Promotes Recovery after Mouse Spinal Cord Injury by Limiting the Recruitment and Activation of Ly6Clo/iNOS+ Macrophages. Journal Of Neuroscience 2011, 31: 9910-9922. PMID: 21734283, PMCID: PMC3139517, DOI: 10.1523/jneurosci.2114-11.2011.Peer-Reviewed Original ResearchMeSH KeywordsAnalysis of VarianceAnimalsAntigens, LyCD11 AntigensCells, CulturedChemokine CXCL1CX3C Chemokine Receptor 1Disease Models, AnimalFlow CytometryGene Expression RegulationGreen Fluorescent ProteinsMacrophagesMiceMice, Inbred C57BLMice, TransgenicMotor ActivityMyelin Basic ProteinNitric OxideNitric Oxide Synthase Type IIReceptors, ChemokineRecovery of FunctionSignal TransductionSpinal Cord InjuriesConceptsSpinal cord injuryMonocyte-derived macrophagesCord injuryMouse spinal cord injuryTraumatic spinal cord injuryBlockade of CX3CR1Novel monocyte subsetsCX3CR1-deficient miceAnti-inflammatory therapySelective anti-inflammatory therapyWild-type miceDistinct macrophage subsetsInflammatory cytokinesMonocyte subsetsChemokine receptorsFunctional improvementSpinal cordInflammatory signalingNeurotoxic effectsPromotes recoveryMacrophage subsetsLesion siteCX3CR1Oxidative metabolitesMice