Featured Publications
A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries
Bhasin S, Gill TM, Reuben DB, Latham NK, Ganz DA, Greene EJ, Dziura J, Basaria S, Gurwitz JH, Dykes PC, McMahon S, Storer TW, Gazarian P, Miller ME, Travison TG, Esserman D, Carnie MB, Goehring L, Fagan M, Greenspan SL, Alexander N, Wiggins J, Ko F, Siu AL, Volpi E, Wu AW, Rich J, Waring SC, Wallace RB, Casteel C, Resnick NM, Magaziner J, Charpentier P, Lu C, Araujo K, Rajeevan H, Meng C, Allore H, Brawley BF, Eder R, McGloin JM, Skokos EA, Duncan PW, Baker D, Boult C, Correa-de-Araujo R, Peduzzi P. A Randomized Trial of a Multifactorial Strategy to Prevent Serious Fall Injuries. New England Journal Of Medicine 2020, 383: 129-140. PMID: 32640131, PMCID: PMC7421468, DOI: 10.1056/nejmoa2002183.Peer-Reviewed Original ResearchConceptsSerious fall injuriesFall injuriesIntervention groupControl groupUsual careMultifactorial interventionRate of hospitalizationPrimary care practicesCluster-randomized trialCommunity-dwelling adultsFirst-event analysisYears of ageHealth care systemRate of fallElectronic health recordsBaseline characteristicsPrimary outcomeRandomized trialsMean ageEfficacy trialsIndividualized planCare practicesInjuryMultifactorial strategyEvent ratesEffect of a Multifactorial Fall Injury Prevention Intervention on Patient Well‐Being: The STRIDE Study
Gill TM, Bhasin S, Reuben DB, Latham NK, Araujo K, Ganz DA, Boult C, Wu AW, Magaziner J, Alexander N, Wallace RB, Miller ME, Travison TG, Greenspan SL, Gurwitz JH, Rich J, Volpi E, Waring SC, Manini TM, Min LC, Teresi J, Dykes PC, McMahon S, McGloin JM, Skokos EA, Charpentier P, Basaria S, Duncan PW, Storer TW, Gazarian P, Allore HG, Dziura J, Esserman D, Carnie MB, Hanson C, Ko F, Resnick NM, Wiggins J, Lu C, Meng C, Goehring L, Fagan M, Correa‐de‐Araujo R, Casteel C, Peduzzi P, Greene EJ. Effect of a Multifactorial Fall Injury Prevention Intervention on Patient Well‐Being: The STRIDE Study. Journal Of The American Geriatrics Society 2020, 69: 173-179. PMID: 33037632, PMCID: PMC8178516, DOI: 10.1111/jgs.16854.Peer-Reviewed Original ResearchConceptsSerious fall injuriesFall injuriesMultifactorial interventionPhysical functionOutcomes Measurement Information System (PROMIS) AnxietyLeast square mean changePragmatic cluster-randomized trialMean scoreCommunity-living personsIntervention group's mean scoreInjury prevention interventionsPrimary care practicesFalls Efficacy ScaleCluster-randomized trialUsual careElders StudyDisability InstrumentSTRIDE studyDepression ScaleMean changePrevention interventionsHigh riskCare practicesControl groupMeaningful improvements
2023
Sex Differences in Symptom Complexity and Door-to-Balloon Time in Patients With ST-Elevation Myocardial Infarction
Brush J, Chaudhry S, Dreyer R, D'Onofrio G, Greene E, Hajduk A, Lu Y, Krumholz H. Sex Differences in Symptom Complexity and Door-to-Balloon Time in Patients With ST-Elevation Myocardial Infarction. The American Journal Of Cardiology 2023, 197: 101-107. PMID: 37062667, PMCID: PMC10198892, DOI: 10.1016/j.amjcard.2023.03.009.Peer-Reviewed Original ResearchConceptsPercutaneous coronary interventionD2B timeSymptom complexityYoung womenChest painBalloon timeST-elevation myocardial infarctionSILVER-AMI StudySymptom phenotypeSex differencesPain symptomsCoronary interventionOlder patientsMyocardial infarctionOlder womenSTEMIOlder menSymptom patternsPresentation delayPatientsSymptom clustersLogistic regressionSymptomsWomenMean number
2021
Sex Differences in Symptom Phenotypes Among Older Patients with Acute Myocardial Infarction
Brush JE, Hajduk AM, Greene EJ, Dreyer RP, Krumholz HM, Chaudhry SI. Sex Differences in Symptom Phenotypes Among Older Patients with Acute Myocardial Infarction. The American Journal Of Medicine 2021, 135: 342-349. PMID: 34715061, PMCID: PMC8901454, DOI: 10.1016/j.amjmed.2021.09.022.Peer-Reviewed Original ResearchConceptsAcute myocardial infarctionMyocardial infarctionSymptom combinationsOlder patientsAcute myocardial infarction subgroupsAcute myocardial infarction admissionsMyocardial infarction subgroupsPatients 75 yearsMyocardial infarction admissionsSILVER-AMI StudySymptom phenotypeClinical studiesIndividual patientsMore symptomsPatientsInfarctionDiagnostic possibilitiesSymptomsWomenPerson interviewsMenCommon phenotypeSex differencesCliniciansPhenotype
2020
D‐CARE: The Dementia Care Study: Design of a Pragmatic Trial of the Effectiveness and Cost Effectiveness of Health System–Based Versus Community‐Based Dementia Care Versus Usual Dementia Care
Reuben DB, Gill TM, Stevens A, Williamson J, Volpi E, Lichtenstein M, Jennings LA, Tan Z, Evertson L, Bass D, Weitzman L, Carnie M, Wilson N, Araujo K, Charpentier P, Meng C, Greene EJ, Dziura J, Liu J, Unger E, Yang M, Currie K, Lenoir KM, Green A, Abraham S, Vernon A, Samper‐Ternent R, Raji M, Hirst RM, Galloway R, Finney GR, Ladd I, Rahm AK, Borek P, Peduzzi P. D‐CARE: The Dementia Care Study: Design of a Pragmatic Trial of the Effectiveness and Cost Effectiveness of Health System–Based Versus Community‐Based Dementia Care Versus Usual Dementia Care. Journal Of The American Geriatrics Society 2020, 68: 2492-2499. PMID: 32949145, PMCID: PMC8086629, DOI: 10.1111/jgs.16862.Peer-Reviewed Original ResearchConceptsCommunity-based dementia careUsual careClinical trial sitesDementia careHealth systemCaregiver unmet needsNursing home placement ratesClinical health systemsDementia care specialistsUnit of randomizationQuality of lifeCost effectivenessDementia Care StudyPrimary outcomeClinical benefitSuperiority trialFunctional statusPragmatic trialCaregiver dyadsCare specialistsComprehensive careCaregiver distressCare studiesMedicare claimsNurse practitionersOptimizing Retention in a Pragmatic Trial of Community‐Living Older Persons: The STRIDE Study
Gill TM, McGloin JM, Shelton A, Bianco LM, Skokos EA, Latham NK, Ganz DA, Nyquist LV, Wallace RB, Carnie MB, Dykes PC, Goehring LA, Doyle M, Charpentier PA, Greene EJ, Araujo KL. Optimizing Retention in a Pragmatic Trial of Community‐Living Older Persons: The STRIDE Study. Journal Of The American Geriatrics Society 2020, 68: 1242-1249. PMID: 32212395, PMCID: PMC7707554, DOI: 10.1111/jgs.16356.Peer-Reviewed Original ResearchConceptsSerious fall injuriesPragmatic trialFall injuriesCommon reasonClinical sitesOlder personsCommunity-living personsLarge pragmatic trialPrimary care practicesCentral call centerRate of deathYears of ageVulnerable older personsRetention of participantsUS healthcare systemPragmatic clusterStudy withdrawalMultifactorial interventionElders StudySTRIDE studyHigh riskCare practicesParticipant retentionStudy outcomesInjurySex Differences in Symptom Phenotypes Among Patients With Acute Myocardial Infarction
Brush JE, Krumholz HM, Greene EJ, Dreyer RP. Sex Differences in Symptom Phenotypes Among Patients With Acute Myocardial Infarction. Circulation Cardiovascular Quality And Outcomes 2020, 13: e005948. PMID: 32063049, PMCID: PMC7041412, DOI: 10.1161/circoutcomes.119.005948.Peer-Reviewed Original ResearchMeSH KeywordsAdolescentAdultBiological Variation, IndividualFemaleHealth Status DisparitiesHumansInterviews as TopicMaleMiddle AgedMyocardial InfarctionPatient AdmissionPhenotypePredictive Value of TestsProspective StudiesRisk AssessmentRisk FactorsSex FactorsSpainSymptom AssessmentUnited StatesYoung AdultConceptsAcute myocardial infarctionMyocardial infarctionMedical recordsYoung womenDiagnosis of AMIObservational cohort studyMedical record abstractionSymptom phenotypeDiagnostic processAnalysis of symptomsVIRGO StudyCohort studyRecord abstractionIndividual patientsClinician's abilityDiagnosis rateStandardized interviewPhenotype subgroupsSymptomsSimilar findingsYoung adultsWomenMenInfarctionPatients
2019
Association of Racial Disparities With Access to Kidney Transplant After the Implementation of the New Kidney Allocation System
Kulkarni S, Ladin K, Haakinson D, Greene E, Li L, Deng Y. Association of Racial Disparities With Access to Kidney Transplant After the Implementation of the New Kidney Allocation System. JAMA Surgery 2019, 154: 618-625. PMID: 30942882, PMCID: PMC6583835, DOI: 10.1001/jamasurg.2019.0512.Peer-Reviewed Original ResearchConceptsDeceased donor transplantsKidney allocation systemDonor transplantsKidney transplantTransplant probabilityDeath/Race/ethnicityHispanic individualsWhite individualsOrgan procurementBlack individualsNew kidney allocation systemRetrospective cohort studyWait-listed patientsKidney transplant databaseStatus changesAntibody categoriesLevel of sensitizationInactive statusInactive patientsTransplant databaseTransplant outcomesCohort studyMedian ageAntibody group
2018
Screening, Recruitment, and Baseline Characteristics for the Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE) Study
Gill TM, McGloin JM, Latham NK, Charpentier PA, Araujo KL, Skokos EA, Lu C, Shelton A, Bhasin S, Bianco LM, Carnie MB, Covinsky KE, Dykes P, Esserman DA, Ganz DA, Gurwitz JH, Hanson C, Nyquist LV, Reuben DB, Wallace RB, Greene EJ. Screening, Recruitment, and Baseline Characteristics for the Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE) Study. The Journals Of Gerontology Series A 2018, 73: 1495-1501. PMID: 30020415, PMCID: PMC6175032, DOI: 10.1093/gerona/gly076.Peer-Reviewed Original ResearchConceptsSerious fall injuriesFall injuriesHealth care systemPositive screenCare systemLarge pragmatic clusterHigh-risk populationPrimary care practicesDiverse health care systemsMost health care systemsClinic screenEligible patientsPragmatic clusterBaseline characteristicsMultifactorial interventionRecruitment of participantsElders StudySTRIDE studyEligible personsHigh riskRisk populationsRecruitment goalsCare practicesSTRIDE interventionPatientsImpact of Cost Display on Ordering Patterns for Hospital Laboratory and Imaging Services
Silvestri MT, Xu X, Long T, Bongiovanni T, Bernstein SL, Chaudhry SI, Silvestri JI, Stolar M, Greene EJ, Dziura JD, Gross CP, Krumholz HM. Impact of Cost Display on Ordering Patterns for Hospital Laboratory and Imaging Services. Journal Of General Internal Medicine 2018, 33: 1268-1275. PMID: 29845468, PMCID: PMC6082197, DOI: 10.1007/s11606-018-4495-6.Peer-Reviewed Original ResearchConceptsDecreased oddsImaging ordersHealth care servicesBehalf of patientsKey ResultsDuringMain MeasuresOutcomesParticipantsAll patientsHospital encountersImaging testsObservation encountersCare servicesHealth servicesMedicare fee scheduleHealth systemImaging costsDecreased numberHospital laboratoriesLab ordersStudy periodHospital labPatients
2017
Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE): A Cluster-Randomized Pragmatic Trial of a Multifactorial Fall Injury Prevention Strategy: Design and Methods
Bhasin S, Gill TM, Reuben DB, Latham NK, Gurwitz JH, Dykes P, McMahon S, Storer TW, Duncan PW, Ganz DA, Basaria S, Miller ME, Travison TG, Greene EJ, Dziura J, Esserman D, Allore H, Carnie MB, Fagan M, Hanson C, Baker D, Greenspan SL, Alexander N, Ko F, Siu AL, Volpi E, Wu AW, Rich J, Waring SC, Wallace R, Casteel C, Magaziner J, Charpentier P, Lu C, Araujo K, Rajeevan H, Margolis S, Eder R, McGloin JM, Skokos E, Wiggins J, Garber L, Clauser SB, Correa-De-Araujo R, Peduzzi P. Strategies to Reduce Injuries and Develop Confidence in Elders (STRIDE): A Cluster-Randomized Pragmatic Trial of a Multifactorial Fall Injury Prevention Strategy: Design and Methods. The Journals Of Gerontology Series A 2017, 73: 1053-1061. PMID: 29045582, PMCID: PMC6037050, DOI: 10.1093/gerona/glx190.Peer-Reviewed Original ResearchConceptsSerious fall injuriesInjury prevention strategiesFall injuriesPragmatic trialHealth care systemUsual carePrevention strategiesControl groupOlder adultsCare systemMultifactorial risk assessmentCommunity-living personsEnhanced usual carePrimary outcome rateIndividualized care plansPrimary care practicesTarget sample sizeEvidence-based informationSecondary outcomesPrimary outcomeOutcome ratesComanagement modelFall preventionSTRIDE studyMedical attention
2014
Brain Mechanisms Underlying Reality Monitoring for Heard and Imagined Words
Sugimori E, Mitchell KJ, Raye CL, Greene EJ, Johnson MK. Brain Mechanisms Underlying Reality Monitoring for Heard and Imagined Words. Psychological Science 2014, 25: 403-413. PMID: 24443396, PMCID: PMC6069600, DOI: 10.1177/0956797613505776.Peer-Reviewed Original ResearchConceptsReality monitoringFrontal gyrusInferior frontal gyrusSuperior temporal gyrusMiddle frontal gyrusImagined itemsPerceptual detailsHealthy young adultsBrain mechanismsAuditory informationTemporal gyrusSame voiceFunctional MRIPerson's voiceExperiences ScaleWordsYoung adultsGyrusItemsAttributionVoiceParticipantsHearingAdultsScores
2013
Age-related differences in agenda-driven monitoring of format and task information
Mitchell KJ, Ankudowich E, Durbin KA, Greene EJ, Johnson MK. Age-related differences in agenda-driven monitoring of format and task information. Neuropsychologia 2013, 51: 2427-2441. PMID: 23357375, PMCID: PMC3664244, DOI: 10.1016/j.neuropsychologia.2013.01.012.Peer-Reviewed Original ResearchConceptsOld-new recognitionMedial prefrontal cortexOlder adultsAge-related source memory deficitsPrefrontal cortexRepresentational areaSource memory deficitsVisual processing areasAge-related deficitsPattern of resultsLateral parietal cortexYoung adultsAge-related differencesFeatures of eventsSource memoryEquivalent deficitsReflective attentionParietal functionAge differencesTask informationMemory deficitsGreater trialParietal cortexReduced itemProcessing areas
2008
Neuroimaging Evidence for Agenda-Dependent Monitoring of Different Features During Short-Term Source Memory Tests
Mitchell KJ, Raye CL, McGuire JT, Frankel H, Greene EJ, Johnson MK. Neuroimaging Evidence for Agenda-Dependent Monitoring of Different Features During Short-Term Source Memory Tests. Journal Of Experimental Psychology Learning Memory And Cognition 2008, 34: 780-790. PMID: 18605868, DOI: 10.1037/0278-7393.34.4.780.Peer-Reviewed Original ResearchConceptsLateral prefrontal cortexLong-term memoryPrefrontal cortexAnterior ventrolateral prefrontal cortexRight lateral prefrontal cortexSource memory testSource-monitoring processesVentrolateral prefrontal cortexFunctional magnetic resonanceMemory testPerceptual featuresSource decisionsNeural activityMemory studiesPosterior regionMemoryMonitoring processShort-term sourcesSource attributionItemsSpecific informationAttributionTaskJudgmentsFamiliarityRefreshing One of Several Active Representations: Behavioral and Functional Magnetic Resonance Imaging Differences between Young and Older Adults
Raye CL, Mitchell KJ, Reeder JA, Greene EJ, Johnson MK. Refreshing One of Several Active Representations: Behavioral and Functional Magnetic Resonance Imaging Differences between Young and Older Adults. Journal Of Cognitive Neuroscience 2008, 20: 852-862. PMID: 18201130, DOI: 10.1162/jocn.2008.20508.Peer-Reviewed Original ResearchConceptsVentral frontal cortexActive representationOlder adultsFrontal cortexIrrelevant informationFunctional magnetic resonance imaging studyLeft dorsolateral frontal cortexYoung adultsDissociation of functionAge-related differencesDorsolateral frontal cortexMagnetic resonance imaging studyExecutive processesResonance imaging studyExecutive functionResponse timeNew wordsAnterior cingulateAge-related decreaseBehavioral studiesActive itemWordsCortexImaging differencesMedial area
2007
Refreshing: A Minimal Executive Function
Raye CL, Johnson MK, Mitchell KJ, Greene EJ, Johnson MR. Refreshing: A Minimal Executive Function. Cortex 2007, 43: 135-145. PMID: 17334213, DOI: 10.1016/s0010-9452(08)70451-9.Peer-Reviewed Original ResearchConceptsLateral anterior prefrontal cortexDorsolateral prefrontal cortexAnterior prefrontal cortexPrefrontal cortexExecutive functionHealthy young adult participantsVentrolateral prefrontal cortexYoung adult participantsSpecific mental representationsNon-automatic processesExecutive processesMental representationsRehearsal conditionsExperiment 1PFC areasExperiment 2Functional connectivityAdult participantsDifferent functional connectivityBrain areasACT condition
2006
A functional magnetic resonance imaging investigation of short-term source and item memory for negative pictures
Mitchell KJ, Mather M, Johnson MK, Raye CL, Greene EJ. A functional magnetic resonance imaging investigation of short-term source and item memory for negative pictures. Neuroreport 2006, 17: 1543-1547. PMID: 16957605, DOI: 10.1097/01.wnr.0000234743.50442.e5.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingPicture recognition memoryVisual processing areasFunctional magnetic resonanceItem memoryRecognition memoryNeutral picturesNegative picturesNeutral trialsMemory processesShort-term sourcesItem informationBrain activityFeature integrationProcessing areasMemoryNegative trialsGreater activitySource trialsMagnetic resonance imagingArousalPictureResonance imagingParticipantsItemsEmotional Arousal Can Impair Feature Binding in Working Memory
Mather M, Mitchell KJ, Raye CL, Novak DL, Greene EJ, Johnson MK. Emotional Arousal Can Impair Feature Binding in Working Memory. Journal Of Cognitive Neuroscience 2006, 18: 614-625. PMID: 16768364, DOI: 10.1162/jocn.2006.18.4.614.Peer-Reviewed Original ResearchConceptsEmotional arousalSubsequent functional magnetic resonanceFunctional magnetic resonanceSuperior precentral gyrusSource memoryWorking memoryBind featuresFeature bindingNegative picturesMedium arousalMemory processesVisual processingHigh arousalLow arousalBrief delayHigher depression scoresArousalPrecentral gyrusMemoryDepression scoresGreater activityParticipantsDifferent pictureGyrusPicture
2005
An fMRI investigation of short-term source memory in young and older adults
Mitchell KJ, Raye CL, Johnson MK, Greene EJ. An fMRI investigation of short-term source memory in young and older adults. NeuroImage 2005, 30: 627-633. PMID: 16256377, DOI: 10.1016/j.neuroimage.2005.09.039.Peer-Reviewed Original ResearchConceptsOld-new judgmentsSource memory deficitsFunctional magnetic resonance imagingOlder adultsPrefrontal cortexSource memory judgmentsPrevious fMRI findingsLateral prefrontal cortexDorsolateral prefrontal cortexSpecific source informationMemory judgmentsSource memoryRetention intervalFMRI investigationMemory procedureFMRI findingsMemory deficitsBrain areasYoung adultsJudgmentsMagnetic resonance imagingGreater activityAdultsSource informationCortexUsing fMRI to investigate
Johnson MK, Raye CL, Mitchell KJ, Greene EJ, Cunningham WA, Sanislow CA. Using fMRI to investigate. Cognitive, Affective, & Behavioral Neuroscience 2005, 5: 339-361. PMID: 16396094, DOI: 10.3758/cabn.5.3.339.Peer-Reviewed Original ResearchMeSH KeywordsAcoustic StimulationAdolescentAdultBrain MappingCarbamide PeroxideDrug CombinationsEmotionsFemaleHumansImage Processing, Computer-AssistedMagnetic Resonance ImagingMaleMemoryMental RecallMeta-Analysis as TopicPattern Recognition, VisualPeroxidesPhotic StimulationPractice, PsychologicalPrefrontal CortexRetention, PsychologySpace PerceptionTime FactorsUreaVerbal LearningConceptsPrefrontal cortexVentrolateral prefrontal cortexLong-term memoryMore complex tasksCognitive controlEmotional informationSelection demandsExperienced itemsOrbitofrontal cortexAnterior cingulateNeural activityComplex taskFunctional organizationMemoryAnterior componentCortexItemsRefresh circuitFMRICingulateTaskBroad impactParticipantsPrevious studiesDifferent types