The novel cannabinoid CB1 antagonist AM6545 suppresses food intake and food-reinforced behavior
Randall P, Vemuri V, Segovia K, Torres E, Hosmer S, Nunes E, Santerre J, Makriyannis A, Salamone J. The novel cannabinoid CB1 antagonist AM6545 suppresses food intake and food-reinforced behavior. Pharmacology Biochemistry And Behavior 2010, 97: 179-184. PMID: 20713079, PMCID: PMC3522179, DOI: 10.1016/j.pbb.2010.07.021.Peer-Reviewed Original ResearchConceptsAppetite suppressant drugsFood-motivated behaviorHigh-fat dietCentral nervous systemFood-reinforced behaviorSame dose rangeCB1 inverse agonistsUndesirable side effectsChow intakeIntraperitoneal administrationAM6545CB1 receptorsAppetite suppressantsCannabinoid antagonistFood intakeHigh doseSide effectsNervous systemPoor penetrabilityInverse agonistNeutral antagonistsDose rangeMild suppressionIntakeAntagonist