2022
Impaired Cerebral Autoregulation Related Blood Pressure Reductions After Nimodipine Are Associated with Ischemic Changes on EEG After Subarachnoid Hemorrhage (P13-10.002)
Top I, Chen Y, Bartolome D, Rapuano A, Gilmore E, Sheth K, Matouk C, Petersen N, Kim J. Impaired Cerebral Autoregulation Related Blood Pressure Reductions After Nimodipine Are Associated with Ischemic Changes on EEG After Subarachnoid Hemorrhage (P13-10.002). Neurology 2022, 98 DOI: 10.1212/wnl.98.18_supplement.3539.Peer-Reviewed Original ResearchBlood pressure reductionIschemic changesSubarachnoid hemorrhagePressure reductionHemorrhageNimodipine
2019
Deviation From Personalized Blood Pressure Targets Is Associated With Worse Outcome After Subarachnoid Hemorrhage
Silverman A, Kodali S, Strander S, Gilmore EJ, Kimmel A, Wang A, Cord B, Falcone G, Hebert R, Matouk C, Sheth KN, Petersen NH. Deviation From Personalized Blood Pressure Targets Is Associated With Worse Outcome After Subarachnoid Hemorrhage. Stroke 2019, 50: 2729-2737. PMID: 31495332, PMCID: PMC6756936, DOI: 10.1161/strokeaha.119.026282.Peer-Reviewed Original ResearchConceptsLimits of autoregulationAneurysmal subarachnoid hemorrhageSubarachnoid hemorrhageFunctional outcomeArterial pressureIntracranial pressureBP targetsWorse outcomesPercent timeBlood pressure targetsBlood pressure managementMean arterial pressureModified Rankin ScalePotential neuroprotective strategiesWorse functional outcomePoor functional outcomeCerebral blood flowMultivariate logistic regressionTotal monitoring periodAutoregulatory indexPressure targetsCerebral ischemiaNeuroprotective strategiesRankin ScaleCerebral autoregulationDeviation from Dynamic and Personalized Optimal Blood Pressure Targets is Associated With Worse Functional Outcomes After Aneurysmal Subarachnoid Hemorrhage
Silverman A, Kodali S, Strander S, Gilmore E, Kimmel A, Wang A, Cord B, Falcone G, Hebert R, Matouk C, Sheth K, Petersen N. Deviation from Dynamic and Personalized Optimal Blood Pressure Targets is Associated With Worse Functional Outcomes After Aneurysmal Subarachnoid Hemorrhage. Neurosurgery 2019, 66: 310-186. DOI: 10.1093/neuros/nyz310_186.Peer-Reviewed Original ResearchEarly Prognostication of 1-Year Outcome After Subarachnoid Hemorrhage: The FRESH Score Validation
Witsch J, Kuohn L, Hebert R, Cord B, Sansing L, Gilmore EJ, Hwang DY, Petersen N, Falcone GJ, Matouk C, Sheth KN. Early Prognostication of 1-Year Outcome After Subarachnoid Hemorrhage: The FRESH Score Validation. Journal Of Stroke And Cerebrovascular Diseases 2019, 28: 104280. PMID: 31326270, DOI: 10.1016/j.jstrokecerebrovasdis.2019.06.038.Peer-Reviewed Original ResearchConceptsSpontaneous subarachnoid hemorrhageModified Rankin ScaleLong-term outcomesSubarachnoid hemorrhageUnfavorable outcomePercent of patientsExclusion of patientsStratification of patientsScore variablesAneurysmal etiologyBleeding sourceRankin ScaleFunctional outcomeMean ageEarly prognosticationPrognostication scoresStudy investigatorsHospital resourcesPatientsDisability partAneurysm coilingOutcomesHigh gradeCharacteristic curveHemorrhageDynamic Cerebral Autoregulation and Personalized Blood Pressure Monitoring in Patients with Aneurysmal Subarachnoid Hemorrhage (aSAH) (P5.3-025)
Silverman A, Wang A, Kodali S, Strander S, Cord B, Hebert R, Matouk C, Sheth K, Gilmore E, Petersen N. Dynamic Cerebral Autoregulation and Personalized Blood Pressure Monitoring in Patients with Aneurysmal Subarachnoid Hemorrhage (aSAH) (P5.3-025). Neurology 2019, 92 DOI: 10.1212/wnl.92.15_supplement.p5.3-025.Peer-Reviewed Original Research
2016
Aneurysmal subarachnoid hemorrhage and severe, catheter-induced vasospasm associated with excessive consumption of a caffeinated energy drink
Grant RA, Cord BJ, Kuzomunhu L, Sheth K, Gilmore E, Matouk CC. Aneurysmal subarachnoid hemorrhage and severe, catheter-induced vasospasm associated with excessive consumption of a caffeinated energy drink. Interventional Neuroradiology 2016, 22: 674-678. PMID: 27481912, PMCID: PMC5564359, DOI: 10.1177/1591019916660868.Peer-Reviewed Original ResearchConceptsCatheter-induced vasospasmAneurysmal subarachnoid hemorrhageSubarachnoid hemorrhageCaffeinated energy drinkExcessive energy drink consumptionSudden cardiac deathAnterior communicating arteryEnergy drinksEnergy drink consumptionExcessive consumptionCoronary vasospasmNeurointerventional literatureEndovascular repairThrombotic complicationsCardiac deathSerious complicationsVasoactive substancesCerebrovascular physiologyCommunicating arteryAlert cliniciansDrink consumptionVasospasmCounter stimulantsComplicationsHemorrhageInterrater Agreement for Consensus Definitions of Delayed Ischemic Events After Aneurysmal Subarachnoid Hemorrhage
Zafar SF, Westover MB, Gaspard N, Gilmore EJ, Foreman BP, O'Connor KL, Rosenthal ES. Interrater Agreement for Consensus Definitions of Delayed Ischemic Events After Aneurysmal Subarachnoid Hemorrhage. Journal Of Clinical Neurophysiology 2016, 33: 235-240. PMID: 27258447, PMCID: PMC4894325, DOI: 10.1097/wnp.0000000000000276.Peer-Reviewed Original ResearchConceptsDelayed ischemic eventsCerebral infarctionNeurologic declineSubarachnoid hemorrhageConsensus definitionIschemic eventsCerebral ischemiaClinical trialsInterrater agreementPerfect overall agreementRadiographic cerebral infarctionPercent of patientsAneurysmal subarachnoid hemorrhageFuture large-scale studiesSuccessful clinical trialsMotor scoresMotor declineOutcome studiesInfarctionIschemiaType 1HemorrhageCT imagingLarge-scale studiesMRI techniquesSeizures and Epileptiform Patterns in SAH and Their Relation to Outcomes
Maciel CB, Gilmore EJ. Seizures and Epileptiform Patterns in SAH and Their Relation to Outcomes. Journal Of Clinical Neurophysiology 2016, 33: 183-195. PMID: 27258441, DOI: 10.1097/wnp.0000000000000268.Peer-Reviewed Original ResearchConceptsSubarachnoid hemorrhageAssociation of seizuresMedication side effectsImpact of seizuresSevere subarachnoid hemorrhageRisk-benefit ratioSeizure prophylaxisAntiepileptic treatmentDifferent time pointsNeurovascular complicationsYounger patientsInterictal patternsHeterogeneous pathophysiologyNeurophysiologic monitoringSubclinical seizuresCortical irritationNew anticonvulsantsTherapeutic dosingTherapeutic approachesHigh riskSide effectsFavorable profileEpileptiform patternsSeizuresBurden quantification
2012
Impact of Prolonged Periodic Epileptiform Discharges on Coma Prognosis
Ong C, Gilmore E, Claassen J, Foreman B, Mayer SA. Impact of Prolonged Periodic Epileptiform Discharges on Coma Prognosis. Neurocritical Care 2012, 17: 39-44. PMID: 22700361, DOI: 10.1007/s12028-012-9728-7.Peer-Reviewed Original ResearchConceptsRecovery of consciousnessComatose patientsElectrographic seizuresCEEG monitoringEpileptiform dischargesAdmission Glasgow Coma Scale scoreGlasgow Coma Scale scoreHypoxic-ischemic encephalopathyGlasgow Outcome ScaleTime of dischargeContinuous EEG monitoringNumber of AEDsPeriodic epileptiform dischargesComa prognosisResultsMean ageMedian durationCommon diagnosisIntracerebral hemorrhageFocal hypermetabolismNeuro-ICUSubarachnoid hemorrhageFrequent findingOutcome ScaleClinical significanceLikelihood of survivalAcute Effects of Nimodipine on Cerebral Vasculature and Brain Metabolism in High Grade Subarachnoid Hemorrhage Patients
Choi HA, Ko SB, Chen H, Gilmore E, Carpenter AM, Lee D, Claassen J, Mayer SA, Schmidt JM, Lee K, Connelly ES, Paik M, Badjatia N. Acute Effects of Nimodipine on Cerebral Vasculature and Brain Metabolism in High Grade Subarachnoid Hemorrhage Patients. Neurocritical Care 2012, 16: 363-367. PMID: 22262041, DOI: 10.1007/s12028-012-9670-8.Peer-Reviewed Original ResearchConceptsPoor-grade subarachnoid hemorrhageOral nimodipineSubarachnoid hemorrhageMmHg decreasePoor-grade SAH patientsDoses of nimodipineAdministration of nimodipineAneurysmal subarachnoid hemorrhageSubarachnoid hemorrhage patientsRoutine clinical careAcute PhysiologicAdequate CBFNimodipine administrationOnly medicationHemorrhage patientsMultimodality monitoringSAH patientsVasopressor medicationsBrain metabolismAcute effectsObservational studyMetabolic effectsCerebral vasculatureClinical careNimodipine
2010
Seizures and CNS Hemorrhage
Gilmore E, Choi HA, Hirsch LJ, Claassen J. Seizures and CNS Hemorrhage. The Neurologist 2010, 16: 165-175. PMID: 20445426, DOI: 10.1097/nrl.0b013e3181c7cd0b.Peer-Reviewed Original ResearchConceptsAneurysmal subarachnoid hemorrhageCentral nervous system hemorrhageShort-term prophylaxisNonconvulsive seizuresIntracerebral hemorrhageSpontaneous intracerebral hemorrhageSeizure prophylaxisASAH patientsAdditional injuriesAcute brain injuryPoor clinical gradeEvidence-based guidelinesCommon neurologic conditionsDeleterious effectsAntiepileptic medicationsControlled TrialsConvulsive seizuresCNS hemorrhagePoor outcomeSubarachnoid hemorrhageNeurologic conditionsSurrogate markerBrain injuryClinical gradeRecent injury