2024
13 Prognostication in super refractory status epilepticus: Preliminary results from an international survey study
Woodward M, Brown J, Badjatia N, Morris N, Johnson E, Gilmore E. 13 Prognostication in super refractory status epilepticus: Preliminary results from an international survey study. Journal Of Clinical And Translational Science 2024, 8: 4-4. PMCID: PMC11023845, DOI: 10.1017/cts.2024.34.Peer-Reviewed Original ResearchHealth care providersWithdrawal of life-sustaining therapySuper-refractory status epilepticusHCP responsesAdvanced practice providersPerceived poor neurologic prognosisLife-sustaining therapyCountry of practiceTreating super-refractory status epilepticusHypothetical clinical casesRefractory status epilepticusLogistic regression modelsPractice providersCare providersSurveyed cliniciansCare escalationYears of experienceClinician-specific factorsMedical futilityPotential confoundersPoor neurologic prognosisRespondent demographicsStatus epilepticusInternational survey studyAssociated with high mortalityComparison of induction agents for rapid sequence intubation in refractory status epilepticus: A single-center retrospective analysis
Woodward M, Kardon A, Manners J, Schleicher S, Pergakis M, Ciryam P, Podell J, Denney Zimmerman W, Galvagno S, Butt B, Pritchard J, Parikh G, Gilmore E, Badjatia N, Morris N. Comparison of induction agents for rapid sequence intubation in refractory status epilepticus: A single-center retrospective analysis. Epilepsy & Behavior Reports 2024, 25: 100645. PMID: 38299124, PMCID: PMC10827579, DOI: 10.1016/j.ebr.2024.100645.Peer-Reviewed Original ResearchRefractory status epilepticusNeurocritical care unitEtomidate inductionStatus epilepticusSingle-center retrospective analysisSingle-center retrospective reviewRapid sequence intubationHospital intubationPrimary endpointSeizure cessationAnesthetic medicationsCare unitElectrographic seizuresRetrospective reviewEndotracheal intubationSequence intubationInduction agentRetrospective analysisIntubationHigh incidencePatientsLogistic regressionSeizuresEnriched populationEpilepticus
2018
S18. Hypotension after ketamine administration for refractory status epilepticus in patients at risk of shock
Sheikh Z, Owusu K, Ammar A, Landreneau M, Heck C, Gilmore E. S18. Hypotension after ketamine administration for refractory status epilepticus in patients at risk of shock. Clinical Neurophysiology 2018, 129: e149. DOI: 10.1016/j.clinph.2018.04.378.Peer-Reviewed Original ResearchRefractory status epilepticusStatus epilepticusEjection fractionApical hypokinesisShock indexMidazolam infusionDay 7Middle cerebral artery strokeAcute rehabilitation facilityDiscontinuation of ketamineDiscontinuation of vasopressorsElevated shock indexHospital day 7Improved ejection fractionInitiation of vasopressorsPotential hemodynamic effectsUse of vasopressorsChronic kidney diseaseAnti-seizure drugsUse of ketamineDoses of norepinephrineFocal clonic seizuresRisk of shockHemodynamic profileBeta blockers
2017
Ictal-Interictal Continuum: When to Worry About the Continuous Electroencephalography Pattern
Cormier J, Maciel CB, Gilmore EJ. Ictal-Interictal Continuum: When to Worry About the Continuous Electroencephalography Pattern. Seminars In Respiratory And Critical Care Medicine 2017, 38: 793-806. PMID: 29262437, DOI: 10.1055/s-0037-1607987.Peer-Reviewed Original ResearchConceptsNonconvulsive status epilepticusIctal-interictal continuumNonconvulsive seizuresEEG patternsSecondary brain injuryContinuous electroencephalography monitoringCritical care physiciansClear clinical significanceIIC patternsIll patientsStatus epilepticusCare physiciansCEEG monitoringElectroencephalography monitoringSeizure riskBrain injuryGuideline statementsClinical dilemmaClinical significanceNeuronal stressClinical approachDefinitive guidelinesElectroencephalography patternsPotential associationEarly detectionSeizures and Status Epilepticus
Harris C, Gilmore E. Seizures and Status Epilepticus. 2017, 201-221. DOI: 10.1007/978-3-319-48669-7_12.Peer-Reviewed Original Research
2016
Status Epilepticus
Gilmore E, Nourollahzadeh E. Status Epilepticus. 2016, 23-33. DOI: 10.1007/978-3-319-33341-0_3.Peer-Reviewed Original ResearchManagement of seizuresStatus epilepticusSurgical intensive care unitLarge prospective epidemiologic studiesCommon neurological emergencyICU-related complicationsProspective epidemiologic studiesIntensive care unitOvert clinical manifestationsContinuous EEG monitoringMajority of seizuresNeurologic sequelaeCritical illnessSurgical ICUIll patientsSubstantial morbidityCare unitNeurological emergencyClinical manifestationsEarly recognitionMental statusWorse outcomesEpilepticusIctal activityEpidemiologic studiesUnderstanding and Managing the Ictal-Interictal Continuum in Neurocritical Care
Sivaraju A, Gilmore EJ. Understanding and Managing the Ictal-Interictal Continuum in Neurocritical Care. Current Treatment Options In Neurology 2016, 18: 8. PMID: 26874841, DOI: 10.1007/s11940-015-0391-0.Peer-Reviewed Original ResearchIctal-interictal continuumSpike-wave dischargesNeuronal injuryEEG patternsStatus epilepticusIctal-interictal continuum (IIC) patternsIntensive care unit settingClear clinical correlatePossible neuronal injuryBrain imaging findingsDepth electrode recordingsUse of anestheticsIntracranial pressure fluctuationsElectrographic improvementMultiple AEDsEnolase levelsIll patientsInterictal patternsAntiepileptic drugsElectrographic seizuresImaging findingsElectrographic patternsNeurocritical careClinical correlatesUnit setting
2015
Clinical Correlates and Prognostic Significance of Lateralized Periodic Discharges in Patients Without Acute or Progressive Brain Injury
Sainju RK, Manganas LN, Gilmore EJ, Petroff OA, Rampal N, Hirsch LJ, Gaspard N. Clinical Correlates and Prognostic Significance of Lateralized Periodic Discharges in Patients Without Acute or Progressive Brain Injury. Journal Of Clinical Neurophysiology 2015, 32: 495-500. PMID: 26200591, DOI: 10.1097/wnp.0000000000000206.Peer-Reviewed Original ResearchConceptsProgressive brain injuryAcute brain injuryBrain injuryAbnormal consciousnessPeriodic dischargesClinical correlatesFunctional declineLateralized periodic dischargesRemote brain injuryOutcomes of patientsCase-control studyContinuous EEG monitoringHistory of epilepsyRadiologic evidenceHospital dischargeStatus epilepticusWorse prognosisAcute injuryPrognostic significanceWorse outcomesEEG monitoringMultivariate analysisInjuryPatientsLower likelihoodStatus epilepticus epidemiology—tracking a moving target
Gilmore EJ, Hirsch LJ. Status epilepticus epidemiology—tracking a moving target. Nature Reviews Neurology 2015, 11: 377-378. PMID: 26100743, DOI: 10.1038/nrneurol.2015.104.Peer-Reviewed Original Research