2018
Gene-Centric Analysis of Preeclampsia Identifies Maternal Association at PLEKHG1
Gray KJ, Kovacheva VP, Mirzakhani H, Bjonnes AC, Almoguera B, DeWan AT, Triche EW, Saftlas AF, Hoh J, Bodian DL, Klein E, Huddleston KC, Ingles SA, Lockwood CJ, Hakonarson H, McElrath TF, Murray JC, Wilson ML, Norwitz ER, Karumanchi SA, Bateman BT, Keating BJ, Saxena R. Gene-Centric Analysis of Preeclampsia Identifies Maternal Association at PLEKHG1. Hypertension 2018, 72: 408-416. PMID: 29967039, PMCID: PMC6043396, DOI: 10.1161/hypertensionaha.117.10688.Peer-Reviewed Original Research
2016
Genetic predisposition to elevated levels of C-reactive protein is associated with a decreased risk for preeclampsia
Spracklen CN, Smith CJ, Saftlas AF, Triche EW, Bjonnes A, Keating BJ, Saxena R, Breheny PJ, Dewan AT, Robinson JG, Hoh J, Ryckman KK. Genetic predisposition to elevated levels of C-reactive protein is associated with a decreased risk for preeclampsia. Hypertension In Pregnancy 2016, 36: 30-35. PMID: 27657194, PMCID: PMC5538572, DOI: 10.1080/10641955.2016.1223303.Peer-Reviewed Original ResearchConceptsC-reactive proteinGenetic risk scoreRisk of preeclampsiaBody mass indexGenetic predispositionCRP levelsPreeclampsia casesRisk scoreCRP genetic risk scoreElevated C-reactive proteinLeisure-time physical activityBlood CRP levelsIndependent replication populationMarkers of preeclampsiaElevated levelsMedical chart reviewLive birth certificatesLogistic regression analysisInverse linear trendChart reviewIowa womenNormotensive controlsDecreased riskMass indexPhysical activity
2015
Pre-Pregnancy BMI, Gestational Weight Gain, and the Risk of Hypertensive Disorders of Pregnancy: A Cohort Study in Wuhan, China
Zhou A, Xiong C, Hu R, Zhang Y, Bassig BA, Triche E, Yang S, Qiu L, Zhang Y, Yao C, Xu S, Wang Y, Xia W, Qian Z, Zheng T, Zhang B. Pre-Pregnancy BMI, Gestational Weight Gain, and the Risk of Hypertensive Disorders of Pregnancy: A Cohort Study in Wuhan, China. PLOS ONE 2015, 10: e0136291. PMID: 26305565, PMCID: PMC4548954, DOI: 10.1371/journal.pone.0136291.Peer-Reviewed Original ResearchConceptsTotal gestational weight gainGestational weight gainRisk of HDPPre-pregnancy BMIRisk factorsHypertensive disordersCohort studyBMI gainEarly gestational weight gainMaternal pre-pregnancy BMIChinese womenWeight gainMultiple unconditional logistic regressionLive singleton pregnancyUnconditional logistic regressionNormal-weight counterpartsPutative risk factorsWeight control effortsSingleton pregnanciesMaternal deathsEarly pregnancyIOM recommendationsMedicine recommendationsElevated riskPregnancyGenetic Risk Score for Essential Hypertension and Risk of Preeclampsia
Smith CJ, Saftlas AF, Spracklen CN, Triche EW, Bjonnes A, Keating B, Saxena R, Breheny PJ, Dewan AT, Robinson JG, Hoh J, Ryckman KK. Genetic Risk Score for Essential Hypertension and Risk of Preeclampsia. American Journal Of Hypertension 2015, 29: 17-24. PMID: 26002928, PMCID: PMC4692983, DOI: 10.1093/ajh/hpv069.Peer-Reviewed Original ResearchConceptsDiastolic blood pressureSystolic blood pressureGenetic risk scoreRisk of preeclampsiaBlood pressureEssential hypertensionRisk scoreNormotensive pregnant controlsHypertensive complicationsArterial pressurePregnant controlsWeeks' gestationPreeclamptic casesHypertensive stateEpidemiological evidenceHypertensionPreeclampsiaUS populationNonsignificant associationGenetic risk lociGenetic susceptibilitySwab samplesBuccal swab samplesGenetic riskRegression analysis
2014
Genetic Predisposition to Dyslipidemia and Risk of Preeclampsia
Spracklen CN, Saftlas AF, Triche EW, Bjonnes A, Keating B, Saxena R, Breheny PJ, Dewan AT, Robinson JG, Hoh J, Ryckman KK. Genetic Predisposition to Dyslipidemia and Risk of Preeclampsia. American Journal Of Hypertension 2014, 28: 915-923. PMID: 25523295, PMCID: PMC4542907, DOI: 10.1093/ajh/hpu242.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersBlood PressureCase-Control StudiesChi-Square DistributionCholesterol, HDLCholesterol, LDLDyslipidemiasFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansIowaLogistic ModelsMultivariate AnalysisOdds RatioPhenotypePolymorphism, Single NucleotidePre-EclampsiaPregnancyRisk FactorsTriglyceridesYoung Adult
2011
Prenatal Factors for Childhood Blood Pressure Mediated by Intrauterine and/or Childhood Growth?
Wen X, Triche E, Hogan J, Shenassa E, Buka S. Prenatal Factors for Childhood Blood Pressure Mediated by Intrauterine and/or Childhood Growth? Pediatrics 2011, 127: e713-e721. PMID: 21300676, PMCID: PMC3065147, DOI: 10.1542/peds.2010-2000.Peer-Reviewed Original ResearchConceptsOffspring systolic blood pressureSystolic blood pressureIntrauterine growth restrictionPregnancy weight gainBlood pressureYears of ageMaternal smokingPrenatal factorsChildhood growthPrepregnancy BMIBMI trajectoriesChildhood systolic blood pressureChildren's systolic blood pressureMaternal pregnancy weight gainWeight gainChildhood BMI trajectoriesHeavy maternal smokingOffspring blood pressureChildhood blood pressureMother-child pairsCollaborative Perinatal ProjectChronic hypertensionObstetric formPreeclampsia-eclampsiaChildhood BMI
2010
Association Between Placental Morphology and Childhood Systolic Blood Pressure
Wen X, Triche E, Hogan J, Shenassa E, Buka S. Association Between Placental Morphology and Childhood Systolic Blood Pressure. Hypertension 2010, 57: 48-55. PMID: 21079045, PMCID: PMC3074204, DOI: 10.1161/hypertensionaha.110.162792.Peer-Reviewed Original ResearchConceptsSystolic blood pressureBlood pressureChildhood systolic blood pressureShort-term blood pressureHigher systolic blood pressureLong-term blood pressureLarger placental sizeFull-term singletonsCollaborative Perinatal ProjectDecidual vesselsPlacental inefficiencyPlacental thicknessPregnancy courseVascular resistancePlacental weightPlacental volumePlacental sizeVascular lesionsCord vesselsPlacental morphologyPerinatal ProjectAuscultation methodLesionsAssociationVessels