2020
Prospective, randomized, double-blind, placebo-controlled evaluation of the Pharmacokinetics, Safety and Efficacy of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia
Paidas MJ, Tita ATN, Macones GA, Saade GA, Ehrenkranz RA, Triche EW, Streisand JB, Lam GK, Magann EF, Lewis DF, Dombrowski MP, Werner EF, Branch DW, Habli MA, Grotegut CA, Silver RM, Longo SA, Amon E, Cleary K, How HY, Novotny SR, Grobman WA, Whiteman VE, Wing DA, Scifres CM, Sibai BM. Prospective, randomized, double-blind, placebo-controlled evaluation of the Pharmacokinetics, Safety and Efficacy of Recombinant Antithrombin Versus Placebo in Preterm Preeclampsia. American Journal Of Obstetrics And Gynecology 2020, 223: 739.e1-739.e13. PMID: 32780999, DOI: 10.1016/j.ajog.2020.08.004.Peer-Reviewed Original ResearchMeSH KeywordsAdministration, IntravenousAdolescentAdultAntithrombin ProteinsCesarean SectionDelivery, ObstetricDouble-Blind MethodFemaleFetal DistressGestational AgeHumansInfant, Premature, DiseasesInfant, Small for Gestational AgeMiddle AgedNeonatal SepsisPerinatal MortalityPre-EclampsiaPregnancyPregnancy Trimester, SecondPregnancy Trimester, ThirdProspective StudiesRecombinant ProteinsYoung AdultConceptsRecombinant human antithrombinPreterm preeclampsiaExpectant managementMorbidity scoreHuman antithrombinPlacebo-controlled clinical trialPlacebo-controlled evaluationPlacebo-controlled trialMedian gestational ageMaternal complicationsVersus PlaceboFetal outcomesMaternal outcomesPreterm deliveryEndothelial dysfunctionSecondary outcomesSingleton pregnanciesStandard therapyLoading dosePrimary outcomeWeeks' gestationGestational ageContinuous infusionClinical trialsSaline infusion
2017
The relationship between early childhood head injury and later life criminal behaviour: a longitudinal cohort study
Jackson T, Braun J, Mello M, Triche E, Buka S. The relationship between early childhood head injury and later life criminal behaviour: a longitudinal cohort study. Journal Of Epidemiology & Community Health 2017, 71: 800. PMID: 28663442, DOI: 10.1136/jech-2016-208582.Peer-Reviewed Original ResearchConceptsHead injuryChildhood Head InjurySevere head injuryHead injury casesLongitudinal cohort studyStatistical significanceMulticentre longitudinal studyAges 0Binomial regressionCollaborative Perinatal ProjectProvidence cohortCohort studyConduct problemsUninjured controlsPrenatal factorsChild healthInjury casesPerinatal ProjectInjuryNegative binomial regressionPropensity scoreYoung childhoodHealth recordsLongitudinal studyPsychological problems
2015
Folic acid supplementation in early pregnancy and the risk of preeclampsia, small for gestational age offspring and preterm delivery
Martinussen MP, Bracken MB, Triche EW, Jacobsen GW, Risnes KR. Folic acid supplementation in early pregnancy and the risk of preeclampsia, small for gestational age offspring and preterm delivery. European Journal Of Obstetrics & Gynecology And Reproductive Biology 2015, 195: 94-99. PMID: 26500184, PMCID: PMC4684439, DOI: 10.1016/j.ejogrb.2015.09.022.Peer-Reviewed Original ResearchMeSH KeywordsAdultCohort StudiesFemaleFolic AcidHumansInfant, Low Birth WeightInfant, NewbornInfant, Small for Gestational AgeObesityOdds RatioPre-EclampsiaPregnancyPregnancy ComplicationsPregnancy Trimester, FirstPremature BirthProspective StudiesProtective FactorsRisk FactorsVitamin B ComplexYoung AdultConceptsFolic acid supplementationLow birth weightFolic acid intakePreterm birthAcid supplementationFirst trimesterLean mothersBirth weightAcid intakeEarly pregnancyOdds ratioGestational age offspringProspective cohort studyFolic acid supplementsFolic acid usePregnancy outcome dataRisk of preeclampsiaPossible protective effectMonths of pregnancyObese mothersPreterm deliveryCohort studyObstetric recordsAge offspringFolate intakeEffects of dalfampridine on multi-dimensional aspects of gait and dexterity in multiple sclerosis among timed walk responders and non-responders
Lo A, Ruiz J, Koenig C, Anderson B, Olson K, Triche E. Effects of dalfampridine on multi-dimensional aspects of gait and dexterity in multiple sclerosis among timed walk responders and non-responders. Journal Of The Neurological Sciences 2015, 356: 77-82. PMID: 26139339, DOI: 10.1016/j.jns.2015.06.008.Peer-Reviewed Original ResearchConceptsNon-dominant sideMultiple sclerosisMultiple Sclerosis Walking Scale-12Six-Spot Step TestD-EREffects of dalfampridineMinute walk testHole Peg TestRoutine clinical careWalk respondersWalk testGait impairmentAmbulatory personsPeg TestGross dexterityClinical carePotential treatmentScale-12Block TestSclerosisGaitStep testRespondersFurther investigationSignificant improvement
2014
Low-to-moderate prenatal alcohol consumption and the risk of selected birth outcomes: a prospective cohort study
Lundsberg LS, Illuzzi JL, Belanger K, Triche EW, Bracken MB. Low-to-moderate prenatal alcohol consumption and the risk of selected birth outcomes: a prospective cohort study. Annals Of Epidemiology 2014, 25: 46-54.e3. PMID: 25453352, PMCID: PMC4255148, DOI: 10.1016/j.annepidem.2014.10.011.Peer-Reviewed Original ResearchMeSH KeywordsAdultAlcohol DrinkingConfidence IntervalsConfounding Factors, EpidemiologicConnecticutFemaleFetal Growth RetardationGestational AgeHumansInfant, Low Birth WeightInfant, NewbornLogistic ModelsMassachusettsMaternal-Fetal ExchangeOdds RatioPregnancyPregnancy ComplicationsPregnancy OutcomePremature BirthProspective StudiesRisk FactorsConceptsIntrauterine growth restrictionLow birthweightPreterm deliveryBirth lengthBirth outcomesGrowth restrictionAlcohol exposureOdds ratioLower oddsModerate prenatal alcohol exposureModerate alcohol exposureThird-trimester drinkingProspective cohort studyMultivariable logistic regressionConfidence intervalsPrenatal alcohol consumptionPrenatal alcohol exposurePregnancy drinkingNeonatal outcomesPerinatal outcomesSingleton infantsCohort studyAlcohol drinkingReduced oddsHead circumference
2013
Mediterranean and Dietary Approaches to Stop Hypertension dietary patterns and risk of sudden cardiac death in postmenopausal women 1 , 2 , 3
Bertoia M, Triche E, Michaud D, Baylin A, Hogan J, Neuhouser M, Tinker L, Van Horn L, Waring M, Li W, Shikany J, Eaton C. Mediterranean and Dietary Approaches to Stop Hypertension dietary patterns and risk of sudden cardiac death in postmenopausal women 1 , 2 , 3. American Journal Of Clinical Nutrition 2013, 99: 344-351. PMID: 24351877, PMCID: PMC3893726, DOI: 10.3945/ajcn.112.056135.Peer-Reviewed Original ResearchConceptsSudden cardiac deathFood frequency questionnaireDASH dietary patternDietary patternsCardiac deathDiet scoreDietary ApproachesLower riskRisk of SCDHigher DASH diet scoreHigher Mediterranean diet scoreWomen's Health Initiative studyHypertension (DASH) dietary patternMediterranean diet scoreDASH diet scoreMediterranean dietary patternDevelopment of atherosclerosisHypertension (DASH) dietPostmenopausal womenProspective cohortSymptom onsetSodium intakeHighest quintileLowest quintileHigh intakeExploring the Role of Antithrombin Replacement for the Treatment of Preeclampsia: A Prospective Randomized Evaluation of the Safety and Efficacy of Recombinant Antithrombin in Very Preterm Preeclampsia (PRESERVE‐1)
Paidas MJ, Sibai BM, Triche EW, Frieling J, Lowry S, Group T. Exploring the Role of Antithrombin Replacement for the Treatment of Preeclampsia: A Prospective Randomized Evaluation of the Safety and Efficacy of Recombinant Antithrombin in Very Preterm Preeclampsia (PRESERVE‐1). American Journal Of Reproductive Immunology 2013, 69: 539-544. PMID: 23444920, DOI: 10.1111/aji.12091.Peer-Reviewed Original ResearchConceptsProspective Randomized EvaluationAntithrombin replacementWeeks' gestationRandomized EvaluationRecombinant antithrombinTreatment of preeclampsiaRecombinant human ATExpectant managementPreterm preeclampsiaPrimary endpointMaternal indicationsGestational ageStudy enrollmentAT therapyPreeclampsia studyPreeclampsiaGestationHuman ATAT replacementPharmacokinetic activityAntithrombinEfficacySafetyLaboratory assaysDelivery
2012
Effects of Ambient Pollen Concentrations on Frequency and Severity of Asthma Symptoms Among Asthmatic Children
DellaValle CT, Triche EW, Leaderer BP, Bell ML. Effects of Ambient Pollen Concentrations on Frequency and Severity of Asthma Symptoms Among Asthmatic Children. Epidemiology 2012, 23: 55-63. PMID: 22082997, PMCID: PMC3246281, DOI: 10.1097/ede.0b013e31823b66b8.Peer-Reviewed Original ResearchConceptsShortness of breathRescue medication useAsthma maintenance medicationsMaintenance medicationPersistent coughSensitized childrenChest tightnessNight symptomsAsthmatic childrenMedication usePollen exposureSeverity of asthmaDaily respiratory symptomsWeed pollenLogistic regression analysisLow exposureSeparate logistic regression analysesAsthmatic symptomsRespiratory symptomsDaily symptomsAntibiotic useSymptom outcomesDaily ambientMedicationsAmbient pollen concentrations
2010
Decreased sexual risk behavior in the era of HAART among HIV-infected urban and rural South Africans attending primary care clinics
Venkatesh K, de Bruyn G, Lurie M, Mohapi L, Pronyk P, Moshabela M, Marinda E, Gray G, Triche E, Martinson N. Decreased sexual risk behavior in the era of HAART among HIV-infected urban and rural South Africans attending primary care clinics. AIDS 2010, 24: 2687-2696. PMID: 20808202, PMCID: PMC3130627, DOI: 10.1097/qad.0b013e32833e78d4.Peer-Reviewed Original ResearchConceptsSexual risk behaviorsImpact of HAARTPrimary care clinicsRisk behaviorsHAART initiationCare clinicsSex partnersUnprotected sexPrimary care HIV clinicRural primary care clinicsProspective observational cohortEra of HAARTAntiretroviral treatment programPrimary care programsHIV prevention effortsHIV clinicRural South AfricansClinic visitsCohort studyObservational cohortPrimary outcomeSouth African menHAARTCare programHIVDoes Chocolate Intake During Pregnancy Reduce the Risks of Preeclampsia and Gestational Hypertension?
Saftlas AF, Triche EW, Beydoun H, Bracken MB. Does Chocolate Intake During Pregnancy Reduce the Risks of Preeclampsia and Gestational Hypertension? Annals Of Epidemiology 2010, 20: 584-591. PMID: 20609337, PMCID: PMC2901253, DOI: 10.1016/j.annepidem.2010.05.010.Peer-Reviewed Original ResearchConceptsGestational hypertensionRisk of preeclampsiaAdjusted odds ratioChocolate intakeReduced oddsCardiovascular disease risk markersChocolate consumptionAdverse pregnancy outcomesProspective cohort studyDisease risk markersPrenatal care practicesGH womenCohort studyNormotensive pregnanciesPregnancy outcomesBlood pressureWeeks' gestationThird trimesterHospital deliveryProspective studyRisk markersRisk factorsOdds ratioPrenatal recordsProtective effectMorbidity and Mortality among Infants Born to HIV-Infected Women in South Africa: Implications for Child Health in Resource-Limited Settings
Venkatesh K, de Bruyn G, Marinda E, Otwombe K, van Niekerk R, Urban M, Triche E, McGarvey S, Lurie M, Gray G. Morbidity and Mortality among Infants Born to HIV-Infected Women in South Africa: Implications for Child Health in Resource-Limited Settings. Journal Of Tropical Pediatrics 2010, 57: 109-119. PMID: 20601692, PMCID: PMC3107462, DOI: 10.1093/tropej/fmq061.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-HIV AgentsBreast FeedingChildChild WelfareFemaleFollow-Up StudiesHIV InfectionsHIV-1HospitalizationHumansIncidenceInfantInfectious Disease Transmission, VerticalKaplan-Meier EstimateMaternal AgeMorbidityPregnancyPregnancy Complications, InfectiousProportional Hazards ModelsProspective StudiesSouth AfricaViral LoadYoung AdultConceptsPlasma viral loadMaternal plasma viral loadInfant HIV infectionHIV infectionInfant morbidityChild healthMultivariable Cox proportional hazards modelsCox proportional hazards modelInfant feeding statusPediatric HIV infectionProspective cohort studyRisk of morbidityInfant health outcomesMonths of lifeProportional hazards modelResource limited settingsAntiretroviral prophylaxisMaternal viremiaCohort studyRespiratory infectionsViral loadMaternal ageMorbidityHazards modelHealth outcomes
2006
Peak Expiratory Flow Rate Variability Is Not Affected by Home Combustion Sources in a Group of Nonsmoking Women
Beckett WS, Gent JF, Naeher LP, Belanger K, Triche EW, Bracken MB, Leaderer BP. Peak Expiratory Flow Rate Variability Is Not Affected by Home Combustion Sources in a Group of Nonsmoking Women. Archives Of Environmental & Occupational Health 2006, 61: 176-182. PMID: 17867572, DOI: 10.3200/aeoh.61.4.176-182.Peer-Reviewed Original ResearchMeSH KeywordsAdultAir Pollution, IndoorConnecticutFemaleHeatingHumansLogistic ModelsPeak Expiratory Flow RateProspective StudiesVirginiaConceptsPeak expiratory flowExpiratory flowPeak expiratory flow ratePrevious physician diagnosisExpiratory flow rate variabilityHistory of allergyPeak expiratory flow rate variabilityExpiratory flow rateAmbient air pollutionNonasthmatic womenNonsmoking WomenPhysician diagnosisHispanic ethnicityRate variabilityHealth effectsWomenFlow rate variabilityEducational level
2004
Association of early‐onset otitis media in infants and exposure to household mould
Pettigrew MM, Gent JF, Triche EW, Belanger KD, Bracken MB, Leaderer BP. Association of early‐onset otitis media in infants and exposure to household mould. Paediatric And Perinatal Epidemiology 2004, 18: 441-447. PMID: 15535820, DOI: 10.1111/j.1365-3016.2004.00596.x.Peer-Reviewed Original ResearchConceptsEarly otitis mediaOtitis mediaMonths of ageHousehold moldInfant respiratory symptomsAcute otitis mediaPhysician-diagnosed asthmaCohort of infantsOtitis media episodesRecurrent otitis mediaEarly onset otitis mediaMonths of lifeQuarterly telephone interviewsRespiratory symptomsCommon infectionsProspective studyPotential confoundersHigh riskInfant's birthStandardised questionnaireTelephone interviewsMonthsAsthmaEarly childhoodFurther studiesInfant Otitis Media and the Use of Secondary Heating Sources
Pettigrew MM, Gent JF, Triche EW, Belanger KD, Bracken MB, Leaderer BP. Infant Otitis Media and the Use of Secondary Heating Sources. Epidemiology 2004, 15: 13-20. PMID: 14712142, DOI: 10.1097/01.ede.0000101292.41006.2e.Peer-Reviewed Original ResearchMeSH KeywordsEnvironmental ExposureEpidemiologic StudiesFemaleHeatingHumansInfantInfant WelfareMaleOtitis MediaProspective StudiesRecurrenceRegression AnalysisConceptsRecurrent otitis mediaOtitis media episodesOtitis mediaOtitis media riskOffice visitsDay careMaternal historyWhite raceAssociation of exposureHome heating sourcesDoctor office visitsLogistic regression modelingMedium riskProspective studyPotential confoundersMore episodesSecondary heating sourcesVirginia HospitalWood stove useLogistic regressionTelephone interviewsMultivariate modelAdditional childrenIntermittent useCare
2003
Asthma symptoms, severity, and drug therapy: a prospective study of effects on 2205 pregnancies.
Bracken MB, Triche EW, Belanger K, Saftlas A, Beckett WS, Leaderer BP. Asthma symptoms, severity, and drug therapy: a prospective study of effects on 2205 pregnancies. Obstetrics And Gynecology 2003, 102: 739-52. PMID: 14551004, DOI: 10.1016/s0029-7844(03)00621-5.Peer-Reviewed Original ResearchMeSH KeywordsAdultAnti-Asthmatic AgentsAnti-Inflammatory AgentsAsthmaBirth WeightCase-Control StudiesConnecticutFemaleFetal Growth RetardationFetal Membranes, Premature RuptureHumansInfant, Low Birth WeightInfant, NewbornMassachusettsPregnancyPregnancy ComplicationsPregnancy OutcomeProspective StudiesRisk FactorsSeverity of Illness IndexSteroidsTheophyllineConceptsAsthma symptomsOral steroidsAsthma diagnosisPreterm deliveryPregnant womenHistory of asthmaIntrauterine growth restrictionIUGR infantsAsthma guidelinesAsthma historyController medicationsModerate asthmaAsthma therapyPregnant patientsSymptomatic patientsAsthma severityFetal effectsSymptomatic womenProspective studyDrug therapyGrowth restrictionAsthmaSymptomsMedicationsDiagnosisAssociation of Maternal Caffeine Consumption with Decrements in Fetal Growth
Bracken MB, Triche EW, Belanger K, Hellenbrand K, Leaderer BP. Association of Maternal Caffeine Consumption with Decrements in Fetal Growth. American Journal Of Epidemiology 2003, 157: 456-466. PMID: 12615610, DOI: 10.1093/aje/kwf220.Peer-Reviewed Original ResearchConceptsMaternal caffeine consumptionIntrauterine growth retardationCaffeine consumptionBirth weightCreatinine increaseUrinary caffeineGrowth retardationFirst prenatal visitLarge prospective studiesLow birth weightMean birth weightImportant confounding factorsFetal hazardsPerinatal outcomesPreterm deliveryCreatinine levelsPregnancy outcomesPrenatal visitUrinary cotinineGestational ageSingleton livebirthsThird trimesterProspective studyFetal growthMedical records
2002
Levels of household mold associated with respiratory symptoms in the first year of life in a cohort at risk for asthma.
Gent JF, Ren P, Belanger K, Triche E, Bracken MB, Holford TR, Leaderer BP. Levels of household mold associated with respiratory symptoms in the first year of life in a cohort at risk for asthma. Environmental Health Perspectives 2002, 110: a781-a786. PMID: 12460818, PMCID: PMC1241132, DOI: 10.1289/ehp.021100781.Peer-Reviewed Original ResearchConceptsPersistent coughRespiratory symptomsDays of wheezeHigh-risk groupFirst yearPotential confounding factorsPoisson regression analysisCFU/m3Infant's first yearMaternal allergyMaternal historyHigh riskCoughWheezeAsthmaParticular fungal genusHousehold moldConfounding factorsInfant's lifeColony-forming unitsSignificant riskSocioeconomic statusCertain housing characteristicsHigh levelsSusceptible population
2000
Abortion and Its Effect on Risk of Preeclampsia and Transient Hypertension
Eras J, Saftlas A, Triche E, Hsu C, Risch H, Bracken M. Abortion and Its Effect on Risk of Preeclampsia and Transient Hypertension. Epidemiology 2000, 11: 36-43. PMID: 10615841, DOI: 10.1097/00001648-200001000-00009.Peer-Reviewed Original ResearchConceptsRisk of preeclampsiaTransient hypertensionNulliparous womenDecreased riskMore abortionsPregnancy-related risk factorsHistory of abortionHypertensive disordersWeeks' gestationGestational ageSubsequent pregnancyPrenatal careRisk factorsObstetric practicePrior abortionMonths gestationPreeclampsiaHypertensionInduced abortionReproductive historyReferent groupProtective factorsGestationWomenAbortion