2016
Genetic predisposition to elevated levels of C-reactive protein is associated with a decreased risk for preeclampsia
Spracklen CN, Smith CJ, Saftlas AF, Triche EW, Bjonnes A, Keating BJ, Saxena R, Breheny PJ, Dewan AT, Robinson JG, Hoh J, Ryckman KK. Genetic predisposition to elevated levels of C-reactive protein is associated with a decreased risk for preeclampsia. Hypertension In Pregnancy 2016, 36: 30-35. PMID: 27657194, PMCID: PMC5538572, DOI: 10.1080/10641955.2016.1223303.Peer-Reviewed Original ResearchConceptsC-reactive proteinGenetic risk scoreRisk of preeclampsiaBody mass indexGenetic predispositionCRP levelsPreeclampsia casesRisk scoreCRP genetic risk scoreElevated C-reactive proteinLeisure-time physical activityBlood CRP levelsIndependent replication populationMarkers of preeclampsiaElevated levelsMedical chart reviewLive birth certificatesLogistic regression analysisInverse linear trendChart reviewIowa womenNormotensive controlsDecreased riskMass indexPhysical activity
2014
Genetic Predisposition to Dyslipidemia and Risk of Preeclampsia
Spracklen CN, Saftlas AF, Triche EW, Bjonnes A, Keating B, Saxena R, Breheny PJ, Dewan AT, Robinson JG, Hoh J, Ryckman KK. Genetic Predisposition to Dyslipidemia and Risk of Preeclampsia. American Journal Of Hypertension 2014, 28: 915-923. PMID: 25523295, PMCID: PMC4542907, DOI: 10.1093/ajh/hpu242.Peer-Reviewed Original ResearchMeSH KeywordsAdultBiomarkersBlood PressureCase-Control StudiesChi-Square DistributionCholesterol, HDLCholesterol, LDLDyslipidemiasFemaleGenetic Predisposition to DiseaseGenome-Wide Association StudyHumansIowaLogistic ModelsMultivariate AnalysisOdds RatioPhenotypePolymorphism, Single NucleotidePre-EclampsiaPregnancyRisk FactorsTriglyceridesYoung AdultConceptsRisk of preeclampsiaGenetic risk scoreGenetic predispositionIndependent replication populationReplication populationPreeclampsia casesGenetic markers