NAD kinase regulates the size of the NADPH pool and insulin secretion in pancreatic β-cells
Gray JP, Alavian KN, Jonas EA, Heart EA. NAD kinase regulates the size of the NADPH pool and insulin secretion in pancreatic β-cells. AJP Endocrinology And Metabolism 2012, 303: e191-e199. PMID: 22550069, PMCID: PMC3431206, DOI: 10.1152/ajpendo.00465.2011.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsGlucoseHEK293 CellsHumansInsulinInsulin SecretionInsulin-Secreting CellsMaleMiceMice, Inbred StrainsNADPOxidative StressPhosphotransferases (Alcohol Group Acceptor)RatsRats, Sprague-DawleyConceptsGlucose-stimulated insulin secretionInsulin secretionΒ-cellsPancreatic β-cellsRedox cycling agent menadioneRat β-cell lineΒ-cell lineINS-1 832/13 cellsTwo- to threefold increaseAntioxidant defense systemRodent isletsSecretionGlucose concentrationOxidative damageOxidative defenseThreefold increaseNADPH/Cytosolic reductasesAgent menadione