2020
The new role of F1Fo ATP synthase in mitochondria-mediated neurodegeneration and neuroprotection
Mnatsakanyan N, Jonas EA. The new role of F1Fo ATP synthase in mitochondria-mediated neurodegeneration and neuroprotection. Experimental Neurology 2020, 332: 113400. PMID: 32653453, PMCID: PMC7877222, DOI: 10.1016/j.expneurol.2020.113400.Peer-Reviewed Original ResearchConceptsMitochondrial inner membraneATP synthaseInner membraneOxidative phosphorylationF1Fo-ATP synthaseUnique rotational mechanismMitochondrial inner membrane potentialEfficient cellular metabolismInner membrane potentialMitochondrial permeability transition porePermeability transition poreUnique regulatorAbundant proteinsNew roleCellular metabolismCell lifeProton translocationATP synthesisTransition poreCell survivalElectrochemical gradientCertain pathophysiological conditionsSynthaseATPMembrane potentialCellular Mechanisms of Metabolic Remodeling During Fluid Sheer Stress-Induced Metastasis
Dunn T, Brown S, Mnatsakanyan N, Jonas E, Yonghyun K, Park H. Cellular Mechanisms of Metabolic Remodeling During Fluid Sheer Stress-Induced Metastasis. Current Developments In Nutrition 2020, 4: nzaa044_021. PMCID: PMC7258028, DOI: 10.1093/cdn/nzaa044_021.Peer-Reviewed Original ResearchATP synthaseC subunitBreast cancer cellsMDA-MB-231 cellsMetabolic remodelingCancer cellsCellular mechanismsEnergy metabolismKey enzyme complexMitochondrial energy metabolismMDA-MB-231 breast cancer cellsMDA-MB-231 human breast cancer cellsCell divisionMitochondrial remodelingEnzyme complexHuman breast cancer cellsATP productionMetastatic phenotypeActive transport systemUncoupler FCCPMitochondrial ATPProtein levelsIntracellular ATPATPAbundance
2016
The Mitochondrial Permeability Transition Pore and ATP Synthase
Beutner G, Alavian K, Jonas EA, Porter GA. The Mitochondrial Permeability Transition Pore and ATP Synthase. Handbook Of Experimental Pharmacology 2016, 240: 21-46. PMID: 27590224, PMCID: PMC7439278, DOI: 10.1007/164_2016_5.BooksConceptsPermeability transition poreElectron transport chainATP synthaseGeneration of ATPMitochondrial permeability transition poreATP generationTransition poreCell deathC subunit ringMitochondrial ATP generationFo subunitsEmbryonic mouse heartPTP openingTransport chainOxidative phosphorylationEquivalents NADHMature cellsSynthasePhysiologic roleMouse heartsATPRecent studiesPhosphorylationSubunitsFADH2