2023
Hippocampal Mechanisms Support Cortisol-Induced Memory Enhancements
Sherman B, Harris B, Turk-Browne N, Sinha R, Goldfarb E. Hippocampal Mechanisms Support Cortisol-Induced Memory Enhancements. Journal Of Neuroscience 2023, 43: 7198-7212. PMID: 37813570, PMCID: PMC10601369, DOI: 10.1523/jneurosci.0916-23.2023.Peer-Reviewed Original ResearchConceptsFunctional magnetic resonance imagingMemory enhancementEpisodic memoryAssociative memoryEpisodic memory encodingBrain regionsHigh-resolution functional magnetic resonance imagingHuman hippocampusHigh-resolution fMRIStress-related hormone cortisolHormone cortisolMemory benefitsEmotional memoryMemory encodingEmotional eventsEmotional associationsHippocampal representationsHippocampal signaturesFunctional neuroimagingHippocampal mechanismsStressful eventsFunctional connectivityHippocampal functionMemory formationSalient informationUnderstanding Posttraumatic Stress Disorder With Clues From the Dynamic Brain
Goldfarb E. Understanding Posttraumatic Stress Disorder With Clues From the Dynamic Brain. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2023, 8: 345-346. PMID: 37028902, DOI: 10.1016/j.bpsc.2023.01.006.Peer-Reviewed Original Research
2022
High-Risk Drinkers Engage Distinct Stress-Predictive Brain Networks
Goldfarb EV, Scheinost D, Fogelman N, Seo D, Sinha R. High-Risk Drinkers Engage Distinct Stress-Predictive Brain Networks. Biological Psychiatry Cognitive Neuroscience And Neuroimaging 2022, 7: 805-813. PMID: 35272096, PMCID: PMC9378362, DOI: 10.1016/j.bpsc.2022.02.010.Peer-Reviewed Original ResearchConceptsRisky drinkersHigh-risk drinkersBrain networksMajor public health problemExcessive alcohol intakeWhole-brain functional connectivityPublic health problemEarly preventive interventionsAlcohol use disorderDaily ecological momentary assessmentsAlcohol intakeControl subjectsRisky drinking behaviorsEmotional stress responsesUse disordersEarly markerHealth problemsPreventive interventionsBrain circuitryLight drinkersFunctional connectivityStress protocolHeavy drinkingDrinkersEcological momentary assessment
2021
Elemental and configural threat learning bias extinction generalization
Goldfarb EV, Blow T, Dunsmoor JE, Phelps EA. Elemental and configural threat learning bias extinction generalization. Neurobiology Of Learning And Memory 2021, 180: 107405. PMID: 33609739, PMCID: PMC8076085, DOI: 10.1016/j.nlm.2021.107405.Peer-Reviewed Original ResearchConceptsExtinction generalizationCompound cueNegative emotional eventsTime of learningGroups of participantsMultitude of detailsThreat conditioningElemental learningAversive outcomesEmotional eventsExtinction strategiesExtinction taskAversive eventsEmotional experienceThreat responsesEmotional responsesAbsence of shockCuesMemorySingle representationParticipantsLearningToneImportant implicationsExtinction
2020
Participant stress in the COVID-19 era and beyond
Goldfarb EV. Participant stress in the COVID-19 era and beyond. Nature Reviews Neuroscience 2020, 21: 663-664. PMID: 32978609, PMCID: PMC7517748, DOI: 10.1038/s41583-020-00388-7.Peer-Reviewed Original ResearchHippocampal seed connectome-based modeling predicts the feeling of stress
Goldfarb EV, Rosenberg MD, Seo D, Constable RT, Sinha R. Hippocampal seed connectome-based modeling predicts the feeling of stress. Nature Communications 2020, 11: 2650. PMID: 32461583, PMCID: PMC7253445, DOI: 10.1038/s41467-020-16492-2.Peer-Reviewed Original ResearchMemory biases in alcohol use disorder: enhanced memory for contexts associated with alcohol prospectively predicts alcohol use outcomes
Goldfarb EV, Fogelman N, Sinha R. Memory biases in alcohol use disorder: enhanced memory for contexts associated with alcohol prospectively predicts alcohol use outcomes. Neuropsychopharmacology 2020, 45: 1297-1305. PMID: 32126569, PMCID: PMC7297955, DOI: 10.1038/s41386-020-0650-y.Peer-Reviewed Original ResearchConceptsAlcohol use disorderAssociative memoryItem memoryMemory biasesUse disordersNovel memory taskAlcohol-related associationsDifferent memory systemsAlcohol useLater alcohol usePhotographs of objectsTreatment-seeking individualsTypes of memoryAlcohol use outcomesPrior drinking experienceReal-world behaviorMemory biasMemory taskNeutral scenesDetailed memoriesMemory testMaladaptive useHeavy alcohol useDrinking contextsDrinking experience
2019
Acute Stress Throughout the Memory Cycle: Diverging Effects on Associative and Item Memory
Goldfarb EV, Tompary A, Davachi L, Phelps EA. Acute Stress Throughout the Memory Cycle: Diverging Effects on Associative and Item Memory. Journal Of Experimental Psychology General 2019, 148: 13-29. PMID: 30221962, PMCID: PMC6312485, DOI: 10.1037/xge0000472.Peer-Reviewed Original ResearchConceptsItem memoryAssociative memoryAssociative recognition taskAcute stressForms of memoryStress-induced cortisolAcute stress effectsNeutral objectsNegative wordsRecognition taskSubjective arousalSubjects designMemoryItemsDifferent patternsArousalAssociativeWordsTaskParticipantsStress effectsRelationshipCortisolQuadratic relationshipKey differences
2018
Enhancing memory with stress: Progress, challenges, and opportunities
Goldfarb EV. Enhancing memory with stress: Progress, challenges, and opportunities. Brain And Cognition 2018, 133: 94-105. PMID: 30553573, PMCID: PMC9972486, DOI: 10.1016/j.bandc.2018.11.009.Peer-Reviewed Original ResearchConceptsLong-term memoryDeclarative memoryHippocampal-dependent memory processesMemory-related brain regionsHippocampus-dependent memoryMemory processesMemory functionRodent researchMemoryBrain regionsCentral stress responseFuture researchAcute stressPeripheral stress responsesStress effectsModulatory factorsRodent studiesPositive effectStress responseHuman studiesTranslational gapHumansResearchPhysiological mechanismsRodentsDrug-Induced Glucocorticoids and Memory for Substance Use
Goldfarb EV, Sinha R. Drug-Induced Glucocorticoids and Memory for Substance Use. Trends In Neurosciences 2018, 41: 853-868. PMID: 30170822, PMCID: PMC6204074, DOI: 10.1016/j.tins.2018.08.005.Peer-Reviewed Original Research
2017
Acute Stress Time-dependently Modulates Multiple Memory Systems
Goldfarb EV, Mendelevich Y, Phelps EA. Acute Stress Time-dependently Modulates Multiple Memory Systems. Journal Of Cognitive Neuroscience 2017, 29: 1877-1894. PMID: 28699809, DOI: 10.1162/jocn_a_01167.Peer-Reviewed Original ResearchLow lifetime stress exposure is associated with reduced stimulus–response memory
Goldfarb EV, Shields GS, Daw ND, Slavich GM, Phelps EA. Low lifetime stress exposure is associated with reduced stimulus–response memory. Learning & Memory 2017, 24: 162-168. PMID: 28298555, PMCID: PMC5362698, DOI: 10.1101/lm.045179.117.Peer-Reviewed Original ResearchConceptsLifetime stress exposureStimulus-response memoryStress exposureLifetime stressCumulative lifetime stress exposureStimulus-response associationsForms of psychopathologyYoung adultsHigh lifetime stressLow stress exposureCumulative stress exposureContext memoryMemory performanceDiminished resilienceSR associationsNegative outcomesMemoryModerate levelsNegative effectsLow levelsComputational modelingLow stressAdultsAssessment systemCognitionStress and Cognitive Flexibility: Cortisol Increases Are Associated with Enhanced Updating but Impaired Switching
Goldfarb EV, Froböse MI, Cools R, Phelps EA. Stress and Cognitive Flexibility: Cortisol Increases Are Associated with Enhanced Updating but Impaired Switching. Journal Of Cognitive Neuroscience 2017, 29: 14-24. PMID: 27576026, DOI: 10.1162/jocn_a_01029.Peer-Reviewed Original ResearchConceptsCognitive flexibilityDifferent task demandsTask demandsParticipants' cortisol responsesAcute stress manipulationCortisol responseDMS taskStress-related increasesStress manipulationMultifaceted constructImpaired switchingEffects of stressPFC functionSubjects designDimensions of flexibilityWorse performanceDorsal striatumAcute stressCortisol increaseRelevant informationTaskMost studiesParticipantsConstructsParadigm
2016
Memory-Guided Attention: Independent Contributions of the Hippocampus and Striatum
Goldfarb EV, Chun MM, Phelps EA. Memory-Guided Attention: Independent Contributions of the Hippocampus and Striatum. Neuron 2016, 89: 317-324. PMID: 26777274, PMCID: PMC4871761, DOI: 10.1016/j.neuron.2015.12.014.Peer-Reviewed Original ResearchConceptsContext memoryMemory-guided attentionFunctional magnetic resonance imagingStimulus-response associationsVisual search taskMedial temporal lobeFacilitate attentionAttention benefitsIndividual differencesSearch taskMemory systemTemporal lobeMemoryIndependent contributionNovel evidenceFuture encountersReinforcement learningAttentionMagnetic resonance imagingStriatumHippocampusResonance imagingTaskLearningFacilitation
2014
Gaps in Preparedness of Clergy and Healthcare Providers to Address Mental Health Needs of Returning Service Members
Chevalier L, Goldfarb E, Miller J, Hoeppner B, Gorrindo T, Birnbaum RJ. Gaps in Preparedness of Clergy and Healthcare Providers to Address Mental Health Needs of Returning Service Members. Journal Of Religion And Health 2014, 54: 327-338. PMID: 25112409, DOI: 10.1007/s10943-014-9917-0.Peer-Reviewed Original ResearchMeSH KeywordsAdultBrain InjuriesClergyDepressive DisorderFemaleFocus GroupsHealth PersonnelHealth Services Needs and DemandHumansInterdisciplinary CommunicationMaleMental DisordersMiddle AgedProfessional CompetenceReferral and ConsultationReligion and MedicineSleep Initiation and Maintenance DisordersStress Disorders, Post-TraumaticSuicideSuicide PreventionVeteransAutonomic Arousal and Learning in Web‐Based Simulation: A Feasibility Study
Gorrindo T, Chevalier L, Goldfarb E, Hoeppner BB, Birnbaum RJ. Autonomic Arousal and Learning in Web‐Based Simulation: A Feasibility Study. Journal Of Continuing Education In The Health Professions 2014, 34: s17-s22. PMID: 24935879, DOI: 10.1002/chp.21234.Peer-Reviewed Original Research
2013
Interprofessional Differences in Disposition Decisions: Results From a Standardized Web-Based Patient Assessment
Gorrindo T, Goldfarb E, Chevalier L, Hoeppner BB, Birnbaum RJ, Meller B, Alpert JE, Herman J, Weiss AP. Interprofessional Differences in Disposition Decisions: Results From a Standardized Web-Based Patient Assessment. Psychiatric Services 2013, 64: 808-811. PMID: 23903607, DOI: 10.1176/appi.ps.201200461.Peer-Reviewed Original ResearchConceptsPsychiatric patientsDisposition decisionsLevel of followTypes of cliniciansMental health professionalsPatient assessmentViolence risk assessmentHigh riskHealth professionalsPatientsClinician actionsPsychiatry departmentInterprofessional differencesCliniciansCareTraining differencesTraining backgroundFurther trainingVirtual patientsImportant determinantHigh levelsHospitalizationRisk assessmentFollowDifferencesSimulation-Based Ongoing Professional Practice Evaluation in Psychiatry: A Novel Tool for Performance Assessment
Gorrindo T, Goldfarb E, Birnbaum RJ, Chevalier L, Meller B, Alpert J, Herman J, Weiss A. Simulation-Based Ongoing Professional Practice Evaluation in Psychiatry: A Novel Tool for Performance Assessment. The Joint Commission Journal On Quality And Patient Safety 2013, 39: 319-ap2. PMID: 23888642, DOI: 10.1016/s1553-7250(13)39045-x.Peer-Reviewed Original ResearchConceptsFocused Professional Practice EvaluationProfessional practice evaluationPsychiatry departmentLarge academic medical centerAcademic medical centerOngoing professional practice evaluationE-mail remindersMeasure 2Practice evaluationMedical CenterViolence risk assessmentDaily routineClinical encountersCliniciansClinical performanceCompetency-based evaluationClinical competencyStandardized patientsRisk assessmentAssessment toolParticipantsCorresponding video segmentsWeb-based simulationSummative mannerDepartment
2012
Attendees' perceptions of commercial influence in noncommercially funded CME programs
Goldfarb E, Baer L, Fromson JA, Gorrindo T, Iodice KE, Birnbaum RJ. Attendees' perceptions of commercial influence in noncommercially funded CME programs. Journal Of Continuing Education In The Health Professions 2012, 32: 205-211. PMID: 23008083, DOI: 10.1002/chp.21146.Peer-Reviewed Original ResearchEnhancing informed consent best practices: gaining patient, family and provider perspectives using reverse simulation
Goldfarb E, Fromson JA, Gorrindo T, Birnbaum RJ. Enhancing informed consent best practices: gaining patient, family and provider perspectives using reverse simulation. Journal Of Medical Ethics 2012, 38: 546. PMID: 22522147, DOI: 10.1136/medethics-2011-100206.Peer-Reviewed Original ResearchConceptsHealthcare providersInformed consentPharmacological treatment optionsAtypical antipsychotic medicationsInformed consent discussionAdverse eventsAntipsychotic medicationTreatment optionsCollaborative carePatient retentionTherapeutic effectPsychotic symptomsClinical practicePatientsConsent discussionPatient careClinical settingProvider perspectivesPreventative measuresConsent processMedicationsDoctors' performanceFamily membersExpressed needsCare