2024
Hypertension Management in Peripheral Artery Disease: A Mini Review
Kharawala A, Nagraj S, Pargaonkar S, Seo J, Kokkinidis D, Altin S. Hypertension Management in Peripheral Artery Disease: A Mini Review. Current Hypertension Reviews 2024, 20: 1-9. PMID: 38083897, DOI: 10.2174/0115734021267004231122061712.Peer-Reviewed Original ResearchPeripheral artery diseaseAngiotensin receptor blockersHypertension managementArtery diseaseAmerican Heart Association/American CollegeDevelopment of PADLower extremity peripheral artery diseaseConcomitant peripheral artery diseaseLower blood pressure levelsBlood pressure targetsGuideline-directed therapyUse of angiotensinLarge randomized trialsBlood pressure levelsTreatment of hypertensionMajor risk factorComplex patient populationWorse health outcomesPost Hoc AnalysisAntihypertensive medicationsHypertensive patientsReceptor blockersPressure targetsRandomized trialsAdequate therapy
2023
Sex-specific analysis of intravascular lithotripsy for peripheral artery disease from the Disrupt PAD III observational study
Nagpal S, Altin S, McGinigle K, Mangalmurti S, Adams G, Shammas N, Mehrle A, Soukas P, Bertolet B, Lansky A. Sex-specific analysis of intravascular lithotripsy for peripheral artery disease from the Disrupt PAD III observational study. Journal Of Vascular Surgery 2023, 79: 358-365. PMID: 37925039, DOI: 10.1016/j.jvs.2023.10.058.Peer-Reviewed Original ResearchPeripheral artery diseaseLower extremity peripheral artery diseaseIntravascular lithotripsyResidual stenosisArtery diseaseAcute safetyObservational studyLow ankle-brachial indexUse of IVLChronic limb-threatening ischemiaFinal residual stenosisPeripheral intravascular lithotripsySevere lesion calcificationAnkle-brachial indexLimb-threatening ischemiaReference vessel sizeAbrupt vessel closureHigh complication rateRates of diabetesFisher's exact testSex-specific analysesAngiographic complicationsAtherectomy useIVL treatmentEfficacy outcomesUse of telemedicine facilitated by trained telepresenters to manage advanced peripheral artery disease in rural areas
Breen T, Peake J, Keefe H, Moran J, Kunjukutty F, Pfau S, Altin S. Use of telemedicine facilitated by trained telepresenters to manage advanced peripheral artery disease in rural areas. Vascular Medicine 2023, 28: 239-240. PMID: 36628596, DOI: 10.1177/1358863x221148797.Peer-Reviewed Original Research
2022
Sex-Based Differences in Periprocedural Complications Following Lower Extremity Peripheral Vascular Intervention
Altin S, Gitto M, Secemsky E, Rao S, Hess C. Sex-Based Differences in Periprocedural Complications Following Lower Extremity Peripheral Vascular Intervention. Circulation Cardiovascular Interventions 2022, 15: e011768. PMID: 35938403, DOI: 10.1161/circinterventions.121.011768.Peer-Reviewed Original ResearchConceptsLower extremity peripheral vascular interventionsPeripheral vascular interventionsSymptomatic peripheral artery diseasePeripheral artery diseasePeriprocedural complicationsArtery diseaseHigh riskHospital mortalityKnee amputationFemale sexVascular interventionsVascular Quality Initiative registryAccess site bleedingAccess site complicationsPercutaneous coronary interventionCoronary artery diseaseSex-based outcomesMultivariate logistic regressionWarrants further investigationSex-based differencesBaseline patientSite bleedingCoronary interventionSite complicationsContemporary cohortStatins and statin intensity in peripheral artery disease.
Sagris M, Katsaros I, Giannopoulos S, Rosenberg RD, Altin SE, Rallidis L, Mena-Hurtado C, Armstrong EJ, Kokkinidis DG. Statins and statin intensity in peripheral artery disease. Vasa 2022, 51: 198-211. PMID: 35673949, DOI: 10.1024/0301-1526/a001012.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsPeripheral artery diseaseLow-intensity statinsLoss of patencyStatin useStatin doseIntensity statinsArtery diseaseFirst-line lipid-lowering therapyAdverse cardiovascular eventsAmputation-free survivalHigher statin doseLipid-lowering therapyMyocardial infarction rateRisk of amputationImpact of statinsStatin intensityCardiovascular eventsPAD patientsCardiovascular deathCardiovascular mortalityCause mortalityInfarction rateIschemia patientsStatin treatmentSex Differences in Peripheral Artery Disease
Pabon M, Cheng S, Altin S, Sethi S, Nelson M, Moreau K, Hamburg N, Hess C. Sex Differences in Peripheral Artery Disease. Circulation Research 2022, 130: 496-511. PMID: 35175843, PMCID: PMC8919803, DOI: 10.1161/circresaha.121.320702.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseArtery diseaseManagement of PADSuch sex-based differencesNontraditional risk factorsSex differencesLack of diagnosisSex-based differencesImportant sex differencesIschemic cardiovascularPAD prevalenceVascular stressorSubstantial morbidityClinical presentationClinical manifestationsRisk factorsPrevalent conditionLimb eventsOverall populationVascular substratesDiseaseSex variationWomenCurrent knowledgeManifestations
2020
Predictors of Underutilization of Medical Therapy in Patients Undergoing Endovascular Revascularization for Peripheral Artery Disease
Altin S, Castro-Dominguez Y, Kennedy K, Orion K, Lanksy A, Abbott J, Aronow H. Predictors of Underutilization of Medical Therapy in Patients Undergoing Endovascular Revascularization for Peripheral Artery Disease. JACC Cardiovascular Interventions 2020, 13: 2911-2918. PMID: 33357529, DOI: 10.1016/j.jcin.2020.08.036.Peer-Reviewed Original ResearchConceptsGuideline-directed medical therapyGDMT prescriptionPeripheral artery diseaseAntiplatelet agentsArtery diseaseLower extremity peripheral vascular interventionsAngiotensin receptor blocker useSymptomatic peripheral artery diseaseTraditional atherosclerotic risk factorsChronic limb-threatening ischemiaEnd-stage renal diseaseAtherosclerotic disease burdenDischarge prescription ratesGuideline-recommended therapiesAngiotensin receptor blockersAtherosclerotic risk factorsReceptor blocker useVascular Study GroupLimb-threatening ischemiaPeripheral vascular interventionsVascular Quality InitiativeCongestive heart failureCoronary artery diseaseMultivariate logistic regressionBlocker use