2024
Hypertension Management in Peripheral Artery Disease: A Mini Review
Kharawala A, Nagraj S, Pargaonkar S, Seo J, Kokkinidis D, Altin S. Hypertension Management in Peripheral Artery Disease: A Mini Review. Current Hypertension Reviews 2024, 20: 1-9. PMID: 38083897, DOI: 10.2174/0115734021267004231122061712.Peer-Reviewed Original ResearchPeripheral artery diseaseAngiotensin receptor blockersHypertension managementArtery diseaseAmerican Heart Association/American CollegeDevelopment of PADLower extremity peripheral artery diseaseConcomitant peripheral artery diseaseLower blood pressure levelsBlood pressure targetsGuideline-directed therapyUse of angiotensinLarge randomized trialsBlood pressure levelsTreatment of hypertensionMajor risk factorComplex patient populationWorse health outcomesPost Hoc AnalysisAntihypertensive medicationsHypertensive patientsReceptor blockersPressure targetsRandomized trialsAdequate therapy
2023
Digital Tools for Decision-Making in Coronary Artery Disease
Grubman D, Grubman S, See C, Breen T, Hu J, Altin S. Digital Tools for Decision-Making in Coronary Artery Disease. Current Treatment Options In Cardiovascular Medicine 2023, 25: 737-752. DOI: 10.1007/s11936-023-01022-2.Peer-Reviewed Original ResearchCoronary artery diseaseAcute coronary syndromePercutaneous coronary interventionArtery diseaseRisk stratificationDiagnosis of patientsCoronary syndromeCoronary interventionPoint of carePrimary preventionElectrocardiographic patternCatheterization labClinical uptakeRisk estimation modelCliniciansDiseaseSummaryThe developmentPatientsSyndromeStratificationDiagnosisTriageBiomarkersDigital aidsCareAnatomic patterns in claudicants who fail supervised exercise therapy
Breen T, McGinigle K, Strosberg D, Dardik A, Altin S. Anatomic patterns in claudicants who fail supervised exercise therapy. Journal Of Vascular Surgery 2023, 79: 679-684.e1. PMID: 37984757, DOI: 10.1016/j.jvs.2023.11.020.Peer-Reviewed Original ResearchCritical limb-threatening ischemiaSupervised exercise therapyPeripheral arterial diseaseIntermittent claudicationCFA diseaseExercise therapyArterial diseaseAnatomic patternsCommon femoral artery diseaseFemoral artery diseaseAnkle-brachial indexLimb-threatening ischemiaSubset of patientsVeterans Health AdministrationPersistent symptomsProgressive diseaseProgressive symptomsArtery diseaseDisease locationPatientsWest HavenHealth AdministrationMultivariate analysisRevascularizationDiseaseSex-specific analysis of intravascular lithotripsy for peripheral artery disease from the Disrupt PAD III observational study
Nagpal S, Altin S, McGinigle K, Mangalmurti S, Adams G, Shammas N, Mehrle A, Soukas P, Bertolet B, Lansky A. Sex-specific analysis of intravascular lithotripsy for peripheral artery disease from the Disrupt PAD III observational study. Journal Of Vascular Surgery 2023, 79: 358-365. PMID: 37925039, DOI: 10.1016/j.jvs.2023.10.058.Peer-Reviewed Original ResearchPeripheral artery diseaseLower extremity peripheral artery diseaseIntravascular lithotripsyResidual stenosisArtery diseaseAcute safetyObservational studyLow ankle-brachial indexUse of IVLChronic limb-threatening ischemiaFinal residual stenosisPeripheral intravascular lithotripsySevere lesion calcificationAnkle-brachial indexLimb-threatening ischemiaReference vessel sizeAbrupt vessel closureHigh complication rateRates of diabetesFisher's exact testSex-specific analysesAngiographic complicationsAtherectomy useIVL treatmentEfficacy outcomesUse of telemedicine facilitated by trained telepresenters to manage advanced peripheral artery disease in rural areas
Breen T, Peake J, Keefe H, Moran J, Kunjukutty F, Pfau S, Altin S. Use of telemedicine facilitated by trained telepresenters to manage advanced peripheral artery disease in rural areas. Vascular Medicine 2023, 28: 239-240. PMID: 36628596, DOI: 10.1177/1358863x221148797.Peer-Reviewed Original Research
2022
Sex-Based Differences in Periprocedural Complications Following Lower Extremity Peripheral Vascular Intervention
Altin S, Gitto M, Secemsky E, Rao S, Hess C. Sex-Based Differences in Periprocedural Complications Following Lower Extremity Peripheral Vascular Intervention. Circulation Cardiovascular Interventions 2022, 15: e011768. PMID: 35938403, DOI: 10.1161/circinterventions.121.011768.Peer-Reviewed Original ResearchConceptsLower extremity peripheral vascular interventionsPeripheral vascular interventionsSymptomatic peripheral artery diseasePeripheral artery diseasePeriprocedural complicationsArtery diseaseHigh riskHospital mortalityKnee amputationFemale sexVascular interventionsVascular Quality Initiative registryAccess site bleedingAccess site complicationsPercutaneous coronary interventionCoronary artery diseaseSex-based outcomesMultivariate logistic regressionWarrants further investigationSex-based differencesBaseline patientSite bleedingCoronary interventionSite complicationsContemporary cohortStatins and statin intensity in peripheral artery disease.
Sagris M, Katsaros I, Giannopoulos S, Rosenberg RD, Altin SE, Rallidis L, Mena-Hurtado C, Armstrong EJ, Kokkinidis DG. Statins and statin intensity in peripheral artery disease. Vasa 2022, 51: 198-211. PMID: 35673949, DOI: 10.1024/0301-1526/a001012.Peer-Reviewed Original ResearchConceptsMajor adverse cardiovascular eventsPeripheral artery diseaseLow-intensity statinsLoss of patencyStatin useStatin doseIntensity statinsArtery diseaseFirst-line lipid-lowering therapyAdverse cardiovascular eventsAmputation-free survivalHigher statin doseLipid-lowering therapyMyocardial infarction rateRisk of amputationImpact of statinsStatin intensityCardiovascular eventsPAD patientsCardiovascular deathCardiovascular mortalityCause mortalityInfarction rateIschemia patientsStatin treatmentSex Differences in Peripheral Artery Disease
Pabon M, Cheng S, Altin S, Sethi S, Nelson M, Moreau K, Hamburg N, Hess C. Sex Differences in Peripheral Artery Disease. Circulation Research 2022, 130: 496-511. PMID: 35175843, PMCID: PMC8919803, DOI: 10.1161/circresaha.121.320702.Peer-Reviewed Original ResearchConceptsPeripheral artery diseaseArtery diseaseManagement of PADSuch sex-based differencesNontraditional risk factorsSex differencesLack of diagnosisSex-based differencesImportant sex differencesIschemic cardiovascularPAD prevalenceVascular stressorSubstantial morbidityClinical presentationClinical manifestationsRisk factorsPrevalent conditionLimb eventsOverall populationVascular substratesDiseaseSex variationWomenCurrent knowledgeManifestations
2021
Sex Differences in Intracoronary Imaging and Functional Evaluation of Coronary Arteries
Velagapudi P, Altin S, Schneider M, Alasnag M. Sex Differences in Intracoronary Imaging and Functional Evaluation of Coronary Arteries. Current Cardiovascular Imaging Reports 2021, 14: 7. DOI: 10.1007/s12410-021-09557-3.Peer-Reviewed Original ResearchIntracoronary imagingArtery diseaseCoronary arteryNon-obstructive coronary artery diseaseSpontaneous coronary artery dissectionFunctional evaluationChronic coronary syndromeCoronary artery dissectionCoronary artery diseaseConventional coronary angiographyRecent FindingsThe diagnosisTreatment of womenOptical coherence tomographySex differencesSex-based differencesArtery dissectionCoronary syndromeMicrovascular dysfunctionCoronary angiographyMicrovascular functionClinical outcomesHyperemic responsePlaque characteristicsMyocardial infarctionBroad pathology
2020
Predictors of Underutilization of Medical Therapy in Patients Undergoing Endovascular Revascularization for Peripheral Artery Disease
Altin S, Castro-Dominguez Y, Kennedy K, Orion K, Lanksy A, Abbott J, Aronow H. Predictors of Underutilization of Medical Therapy in Patients Undergoing Endovascular Revascularization for Peripheral Artery Disease. JACC Cardiovascular Interventions 2020, 13: 2911-2918. PMID: 33357529, DOI: 10.1016/j.jcin.2020.08.036.Peer-Reviewed Original ResearchConceptsGuideline-directed medical therapyGDMT prescriptionPeripheral artery diseaseAntiplatelet agentsArtery diseaseLower extremity peripheral vascular interventionsAngiotensin receptor blocker useSymptomatic peripheral artery diseaseTraditional atherosclerotic risk factorsChronic limb-threatening ischemiaEnd-stage renal diseaseAtherosclerotic disease burdenDischarge prescription ratesGuideline-recommended therapiesAngiotensin receptor blockersAtherosclerotic risk factorsReceptor blocker useVascular Study GroupLimb-threatening ischemiaPeripheral vascular interventionsVascular Quality InitiativeCongestive heart failureCoronary artery diseaseMultivariate logistic regressionBlocker useSeasonal variation in U.S. hospitalizations for chronic limb‐threatening ischemia
Altin SE, Kim YG, Aronow HD, Armstrong EJ, Goldsweig AM, Dardik A, Lanksy AJ, Mena‐Hurtado C, Abbott JD. Seasonal variation in U.S. hospitalizations for chronic limb‐threatening ischemia. Catheterization And Cardiovascular Interventions 2020, 96: 1473-1480. PMID: 32902126, DOI: 10.1002/ccd.29261.Peer-Reviewed Original ResearchConceptsCritical limb-threatening ischemiaLimb-threatening ischemiaNational Inpatient SampleMinor amputationChronic limb-threatening ischemiaUtilization Project National Inpatient SampleProvider education effortsCoronary artery diseaseAmputation rateHospital mortalityImportant comorbidityDiabetic statusOverall cohortSecondary outcomesArtery diseaseHospital admissionPrimary outcomeHospitalization incidenceU.S. hospitalizationsDiagnosis codesInpatient SampleHigher oddsAdmission seasonHealthcare costsMortality rateQUANTITATIVE FLOW RATIO ACCORDING TO THREE-DIMENSIONAL QUANTITATIVE CORONARY ANGIOGRAPHY DEFINED SEVERITY OF STENOSIS IN A COHORT OF WOMEN WITH STABLE CORONARY ARTERY DISEASE
Gitto M, Saito Y, Schneider M, Papoutsidakis N, Ardito S, McCarthy M, Cristea E, Lansky A, Altin S. QUANTITATIVE FLOW RATIO ACCORDING TO THREE-DIMENSIONAL QUANTITATIVE CORONARY ANGIOGRAPHY DEFINED SEVERITY OF STENOSIS IN A COHORT OF WOMEN WITH STABLE CORONARY ARTERY DISEASE. Journal Of The American College Of Cardiology 2020, 75: 177. DOI: 10.1016/s0735-1097(20)30804-4.Peer-Reviewed Original ResearchDISCREPANCY BETWEEN VISUALLY ASSESSED AND QUANTITATIVE CORONARY ANGIOGRAPHY DERIVED DIAMETER STENOSIS IN A COHORT OF WOMEN WITH STABLE CORONARY ARTERY DISEASE
Gitto M, Saito Y, Schneider M, Papoutsidakis N, Ardito S, McCarthy M, Cristea E, Lansky A, Altin S. DISCREPANCY BETWEEN VISUALLY ASSESSED AND QUANTITATIVE CORONARY ANGIOGRAPHY DERIVED DIAMETER STENOSIS IN A COHORT OF WOMEN WITH STABLE CORONARY ARTERY DISEASE. Journal Of The American College Of Cardiology 2020, 75: 178. DOI: 10.1016/s0735-1097(20)30805-6.Peer-Reviewed Original Research