1998
Direct link between cytokine activity and a catalytic site for macrophage migration inhibitory factor
Swope M, Sun H, Blake P, Lolis E. Direct link between cytokine activity and a catalytic site for macrophage migration inhibitory factor. The EMBO Journal 1998, 17: 3534-3541. PMID: 9649424, PMCID: PMC1170690, DOI: 10.1093/emboj/17.13.3534.Peer-Reviewed Original ResearchConceptsN-terminal prolineN-terminal regionStructure-based inhibitorsMultiple sequence alignmentThree-dimensional structureInvariant residuesEntire polypeptideMicrobial enzymesCatalytic basePro-1Sequence alignmentMIF homologuesCytokine activityHuman macrophage migration inhibitory factorCatalytic siteProlineInhibitory factorHomologuesUnderlying biological activityP-hydroxyphenylpyruvateProteinMacrophage migration inhibitory factorActive siteBiological activity
1996
Structure-Function Studies of Murine MIP-2, the Homologue of Melanoma Growth Stimulating Activity/gro-α and IL-8
Lolis E, Jerva L. Structure-Function Studies of Murine MIP-2, the Homologue of Melanoma Growth Stimulating Activity/gro-α and IL-8. NATO ASI Series 1996, 183-194. DOI: 10.1007/978-3-642-61180-3_17.Peer-Reviewed Original ResearchHuman melanoma cellsProtein 2Structure-function studiesAnalysis of sequencesLigand-receptor complexesMurine MIP-2Melanoma cellsThree-dimensional structureMurine homologueGene productsAmino terminusMutational analysisInflammatory protein-2Molecular mechanismsIL-8MIP-2High affinityProteinAutocrine growth factorBinding profileHomologuesMetastatic potentialGrowth factorMelanoma growthType B receptors