2022
Differential synthesis of novel small protein times Salmonella virulence program
Salvail H, Choi J, Groisman EA. Differential synthesis of novel small protein times Salmonella virulence program. PLOS Genetics 2022, 18: e1010074. PMID: 35245279, PMCID: PMC8896665, DOI: 10.1371/journal.pgen.1010074.Peer-Reviewed Original ResearchConceptsVirulence programPhoP/PhoQCold-blooded animalsSalmonella enterica serovar TyphimuriumAncestral regulatorGene organizationBicistronic operonEnterica serovar TyphimuriumPolycistronic mRNACellular processesGene controlCorresponding proteinMRNA speciesOperonPhoP phosphorylationGenesSerovar TyphimuriumDifferential synthesisPremature activationS. entericaMRNATranslationUgtLPhoQRibosomes
2006
A Positive Feedback Loop Promotes Transcription Surge That Jump-Starts Salmonella Virulence Circuit
Shin D, Lee EJ, Huang H, Groisman EA. A Positive Feedback Loop Promotes Transcription Surge That Jump-Starts Salmonella Virulence Circuit. Science 2006, 314: 1607-1609. PMID: 17158330, DOI: 10.1126/science.1134930.Peer-Reviewed Original ResearchConceptsSteady-state levelsPositive feedback loopNew steady-state levelVirulence programPhoP phosphorylationInitial surge