2020
Learning About Safety: Conditioned Inhibition as a Novel Approach to Fear Reduction Targeting the Developing Brain
Odriozola P, Gee DG. Learning About Safety: Conditioned Inhibition as a Novel Approach to Fear Reduction Targeting the Developing Brain. American Journal Of Psychiatry 2020, 178: 136-155. PMID: 33167673, PMCID: PMC7951569, DOI: 10.1176/appi.ajp.2020.20020232.Peer-Reviewed Original ResearchConceptsSafety signal learningExtinction learningSignal learningAnxiety disordersAnxious youthSafety cuesDorsal anterior cingulate cortexInhibition of fearFronto-amygdala circuitryCross-species evidenceAnterior cingulate cortexFear responsesAnxiety-like behaviorFrontolimbic circuitryCingulate cortexNeural circuitryCore featuresPrelimbic cortexBasic neuroscienceTranslational frameworkCuesYouthFearLearningAnimal models
2017
The Role of the Endocannabinoid System and Genetic Variation in Adolescent Brain Development
Meyer HC, Lee FS, Gee DG. The Role of the Endocannabinoid System and Genetic Variation in Adolescent Brain Development. Neuropsychopharmacology 2017, 43: 21-33. PMID: 28685756, PMCID: PMC5719094, DOI: 10.1038/npp.2017.143.Peer-Reviewed Original ResearchConceptsAnxiety-related behaviorDevelopmental trajectoriesAdolescent brain developmentRegulation of fearConsequences of stressGenetic variationBrain developmentBehavioral processingECB systemPrefrontal cortexEmotional behaviorHuman genetic variationCorticolimbic structuresStress responsivityBrain regionsAdolescenceRegulation of stressNeural circuitsEndocannabinoid systemAnxietyEnvironmental perturbationsRole of eCBFunctional implicationsCentral roleLife span
2016
Individual differences in frontolimbic circuitry and anxiety emerge with adolescent changes in endocannabinoid signaling across species
Gee DG, Fetcho RN, Jing D, Li A, Glatt CE, Drysdale AT, Cohen AO, Dellarco DV, Yang RR, Dale AM, Jernigan TL, Lee FS, Casey BJ, Jernigan T, San Diego U, McCabe C, San Diego U, Chang L, Hawaii U, Akshoomoff N, San Diego U, Newman E, San Diego U, Dale A, San Diego U, Core M, Ernst T, Hawaii U, Dale A, San Diego U, Van Zijl P, Kuperman J, San Diego U, Murray S, Bloss C, Schork N, Appelbaum M, San Diego U, Gamst A, San Diego U, Thompson W, San Diego U, Bartsch H, San Diego U, Jernigan T, Dale A, Akshoomoff N, Chang L, Ernst T, Keating B, Amaral D, Sowell E, Kaufmann W, Van Zijl P, Mostofsky S, Casey B, Ruberry E, Powers A, Rosen B, Kenet T, Frazier J, Kennedy D, University Y, Gruen J. Individual differences in frontolimbic circuitry and anxiety emerge with adolescent changes in endocannabinoid signaling across species. Proceedings Of The National Academy Of Sciences Of The United States Of America 2016, 113: 4500-4505. PMID: 27001846, PMCID: PMC4843434, DOI: 10.1073/pnas.1600013113.Peer-Reviewed Original ResearchConceptsFatty acid amide hydrolaseAnxiety-related behaviorGene expressionFrontolimbic circuitryEndocannabinoid signalingAnxiety disordersNeural circuit maturationPostnatal day 45Phenotypic differencesFrontoamygdala circuitryAnandamide levelsGenetic effectsAEA levelsBiological stateIndividual differencesCircuit maturationGenetic alterationsFAAH genotypeMouse modelDevelopmental neurobiologyLevels of analysisAdolescent changesDevelopmental windowAmide hydrolaseBrain circuitry