Featured Publications
Associations among negative life events, changes in cortico-limbic connectivity, and psychopathology in the ABCD Study
Brieant AE, Sisk LM, Gee DG. Associations among negative life events, changes in cortico-limbic connectivity, and psychopathology in the ABCD Study. Developmental Cognitive Neuroscience 2021, 52: 101022. PMID: 34710799, PMCID: PMC8556598, DOI: 10.1016/j.dcn.2021.101022.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityNegative life eventsLife eventsInternalizing symptomsAdversity exposureCortico-limbic connectivityParental acceptanceAdolescent Brain Cognitive Development (ABCD) studyLongitudinal structural equation modelLower internalizing symptomsCognitive Development StudyContext of adversityIndirect effectsSample of youthStressful childhood experiencesCortico-limbic networkStructural equation modelLater psychopathologyNeurobiological maturationInternalizing problemsABCD studyFunctional connectivityChildhood experiencesPotential protective effectPsychopathology
2022
Associations among Household and Neighborhood Socioeconomic Disadvantages, Resting-state Frontoamygdala Connectivity, and Internalizing Symptoms in Youth
Ip KI, Sisk LM, Horien C, Conley MI, Rapuano KM, Rosenberg MD, Greene AS, Scheinost D, Constable RT, Casey BJ, Baskin-Sommers A, Gee DG. Associations among Household and Neighborhood Socioeconomic Disadvantages, Resting-state Frontoamygdala Connectivity, and Internalizing Symptoms in Youth. Journal Of Cognitive Neuroscience 2022, 34: 1810-1841. PMID: 35104356, DOI: 10.1162/jocn_a_01826.Peer-Reviewed Original ResearchConceptsSocioeconomic disadvantageNeighbourhood deprivationResting-state functional connectivityInternalizing symptomsSymptoms 1 yearHigher neighborhood deprivationNeighborhood socioeconomic disadvantageCognitive Development StudyAdolescent Brain Cognitive Development (ABCD) studyEarly interventionBilateral amygdalaElevated symptomsNegative connectivitySymptomsFunctional connectivityMental healthPositive connectivityBaselineHigher internalizing symptomsFrontoparietal networkOFC regionsFunctional couplingDeleterious effectsHigh disadvantageNeeds ratio
2018
Atypical frontoamygdala functional connectivity in youth with autism
Odriozola P, Dajani DR, Burrows CA, Gabard-Durnam LJ, Goodman E, Baez AC, Tottenham N, Uddin LQ, Gee DG. Atypical frontoamygdala functional connectivity in youth with autism. Developmental Cognitive Neuroscience 2018, 37: 100603. PMID: 30581125, PMCID: PMC6570504, DOI: 10.1016/j.dcn.2018.12.001.Peer-Reviewed Original ResearchConceptsAutism spectrum disorderRostral anterior cingulate cortexFunctional connectivityTD individualsDifferent age-related patternsResting-state functional connectivityOverall group differencesBroad developmental rangeAnterior cingulate cortexSocioemotional functioningSocioemotional impairmentsSpectrum disorderCross-sectional sampleAge-related changesRight basolateral amygdalaCingulate cortexAge-related patternsGroup differencesDevelopmental rangeFrontoamygdala circuitryBasolateral amygdalaAmygdalaIndividualsPrior workImpairment
2010
Low frequency fluctuations reveal integrated and segregated processing among the cerebral hemispheres
Gee DG, Biswal BB, Kelly C, Stark DE, Margulies DS, Shehzad Z, Uddin LQ, Klein DF, Banich MT, Castellanos FX, Milham MP. Low frequency fluctuations reveal integrated and segregated processing among the cerebral hemispheres. NeuroImage 2010, 54: 517-527. PMID: 20570737, PMCID: PMC3134281, DOI: 10.1016/j.neuroimage.2010.05.073.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityFunctional magnetic resonance imagingFunctional connectivityResting-state functional magnetic resonance imagingInterhemispheric interactionsResting-state fMRI scansSpontaneous low-frequency fluctuationsLow-frequency fluctuationsInterhemispheric processingMagnetic resonance imagingRSFC strengthCerebral hemispheresHomotopic regionsIntrahemispheric processingResonance imagingNegative connectivityEntire cerebrumConnectivity strengthFMRI scansHealthy participantsBOLD signalSegregated processingPresent studyOpposite hemisphereHemisphere