2021
Genetic variation in endocannabinoid signaling is associated with differential network‐level functional connectivity in youth
Sisk LM, Rapuano KM, Conley MI, Greene AS, Horien C, Rosenberg MD, Scheinost D, Constable RT, Glatt CE, Casey BJ, Gee DG. Genetic variation in endocannabinoid signaling is associated with differential network‐level functional connectivity in youth. Journal Of Neuroscience Research 2021, 100: 731-743. PMID: 34496065, PMCID: PMC8866205, DOI: 10.1002/jnr.24946.Peer-Reviewed Original ResearchConceptsEndocannabinoid signalingAllele carriersLower anxiety symptomsC385A polymorphismNetwork-level functional connectivityEnhanced endocannabinoid signalingLarge-scale resting-state brain networksAnxiety symptomsResting-state brain networksGenotype-associated differencesBrain networksFronto-amygdala connectivityFunctional connectionsCognitive Development StudyNetwork-level changesPotential protective factorsAdolescent Brain Cognitive Development (ABCD) studyEndocannabinoid systemNetwork-level differencesYounger ageFunctional connectivityProtective factorsNeural phenotypesAnxiety disordersNeural connectivity
2016
Stimulus-Elicited Connectivity Influences Resting-State Connectivity Years Later in Human Development: A Prospective Study
Gabard-Durnam LJ, Gee DG, Goff B, Flannery J, Telzer E, Humphreys KL, Lumian DS, Fareri DS, Caldera C, Tottenham N. Stimulus-Elicited Connectivity Influences Resting-State Connectivity Years Later in Human Development: A Prospective Study. Journal Of Neuroscience 2016, 36: 4771-4784. PMID: 27122035, PMCID: PMC4846673, DOI: 10.1523/jneurosci.0598-16.2016.Peer-Reviewed Original ResearchConceptsMedial prefrontal cortexFunctional connectivityAmygdala-medial prefrontal cortex circuitInferior frontal gyrusResting-state functional networksFunctional architectureResting-state connectivityAmygdala functional connectivityFunctional network architecturePrefrontal cortex circuitAmygdala-mPFC circuitResting-state networksFunctional connectionsEmotional stimuliCourse of developmentFrontal gyrusAge-related changesPrefrontal cortexMotivate future investigationsCortex circuitPredictive associationsSensitive periodFunctional networksDevelopmental periodBrain function