Featured Publications
Associations among negative life events, changes in cortico-limbic connectivity, and psychopathology in the ABCD Study
Brieant AE, Sisk LM, Gee DG. Associations among negative life events, changes in cortico-limbic connectivity, and psychopathology in the ABCD Study. Developmental Cognitive Neuroscience 2021, 52: 101022. PMID: 34710799, PMCID: PMC8556598, DOI: 10.1016/j.dcn.2021.101022.Peer-Reviewed Original ResearchConceptsResting-state functional connectivityNegative life eventsLife eventsInternalizing symptomsAdversity exposureCortico-limbic connectivityParental acceptanceAdolescent Brain Cognitive Development (ABCD) studyLongitudinal structural equation modelLower internalizing symptomsCognitive Development StudyContext of adversityIndirect effectsSample of youthStressful childhood experiencesCortico-limbic networkStructural equation modelLater psychopathologyNeurobiological maturationInternalizing problemsABCD studyFunctional connectivityChildhood experiencesPotential protective effectPsychopathology
2022
Associations among Household and Neighborhood Socioeconomic Disadvantages, Resting-state Frontoamygdala Connectivity, and Internalizing Symptoms in Youth
Ip KI, Sisk LM, Horien C, Conley MI, Rapuano KM, Rosenberg MD, Greene AS, Scheinost D, Constable RT, Casey BJ, Baskin-Sommers A, Gee DG. Associations among Household and Neighborhood Socioeconomic Disadvantages, Resting-state Frontoamygdala Connectivity, and Internalizing Symptoms in Youth. Journal Of Cognitive Neuroscience 2022, 34: 1810-1841. PMID: 35104356, DOI: 10.1162/jocn_a_01826.Peer-Reviewed Original ResearchConceptsSocioeconomic disadvantageNeighbourhood deprivationResting-state functional connectivityInternalizing symptomsSymptoms 1 yearHigher neighborhood deprivationNeighborhood socioeconomic disadvantageCognitive Development StudyAdolescent Brain Cognitive Development (ABCD) studyEarly interventionBilateral amygdalaElevated symptomsNegative connectivitySymptomsFunctional connectivityMental healthPositive connectivityBaselineHigher internalizing symptomsFrontoparietal networkOFC regionsFunctional couplingDeleterious effectsHigh disadvantageNeeds ratio
2021
Genetic variation in endocannabinoid signaling is associated with differential network‐level functional connectivity in youth
Sisk LM, Rapuano KM, Conley MI, Greene AS, Horien C, Rosenberg MD, Scheinost D, Constable RT, Glatt CE, Casey BJ, Gee DG. Genetic variation in endocannabinoid signaling is associated with differential network‐level functional connectivity in youth. Journal Of Neuroscience Research 2021, 100: 731-743. PMID: 34496065, PMCID: PMC8866205, DOI: 10.1002/jnr.24946.Peer-Reviewed Original ResearchConceptsEndocannabinoid signalingAllele carriersLower anxiety symptomsC385A polymorphismNetwork-level functional connectivityEnhanced endocannabinoid signalingLarge-scale resting-state brain networksAnxiety symptomsResting-state brain networksGenotype-associated differencesBrain networksFronto-amygdala connectivityFunctional connectionsCognitive Development StudyNetwork-level changesPotential protective factorsAdolescent Brain Cognitive Development (ABCD) studyEndocannabinoid systemNetwork-level differencesYounger ageFunctional connectivityProtective factorsNeural phenotypesAnxiety disordersNeural connectivityResponsible Use of Open-Access Developmental Data: The Adolescent Brain Cognitive Development (ABCD) Study
Simmons C, Conley MI, Gee DG, Baskin-Sommers A, Barch DM, Hoffman EA, Huber RS, Iacono WG, Nagel BJ, Palmer CE, Sheth CS, Sowell ER, Thompson WK, Casey BJ. Responsible Use of Open-Access Developmental Data: The Adolescent Brain Cognitive Development (ABCD) Study. Psychological Science 2021, 32: 866-870. PMID: 34043478, PMCID: PMC8726588, DOI: 10.1177/09567976211003564.Peer-Reviewed Original ResearchConceptsAdolescent Brain Cognitive Development (ABCD) studyCognitive Development StudyDevelopmental dataDevelopment studiesDecomposing complex links between the childhood environment and brain structure in school-aged youth
Hong SJ, Sisk LM, Caballero C, Mekhanik A, Roy AK, Milham MP, Gee DG. Decomposing complex links between the childhood environment and brain structure in school-aged youth. Developmental Cognitive Neuroscience 2021, 48: 100919. PMID: 33556882, PMCID: PMC7868609, DOI: 10.1016/j.dcn.2021.100919.Peer-Reviewed Original ResearchConceptsSupportive caregivingAdolescent Brain Cognitive Development (ABCD) studyOverall mental health problemsCross-modal integrationHigh family conflictCognitive Development StudyBrain structuresDistinct environmental exposuresSchool-aged youthMental health problemsSchool-aged childrenGreater cortical thicknessExternalizing symptomsFamily conflictGreater myelinationBehavioral developmentBrain morphometricsStructural neurodevelopmentChildhood experiencesProtective factorsOptimize interventionsNeighborhood safetyDifferent facetsSchool environmentSpecific experiences