2022
Experimental evidence for a child‐to‐adolescent switch in human amygdala‐prefrontal cortex communication: A cross‐sectional pilot study
Gee DG, Hanson C, Caglar LR, Fareri DS, Gabard‐Durnam L, Mills‐Finnerty C, Goff B, Caldera CJ, Lumian DS, Flannery J, Hanson SJ, Tottenham N. Experimental evidence for a child‐to‐adolescent switch in human amygdala‐prefrontal cortex communication: A cross‐sectional pilot study. Developmental Science 2022, 25: e13238. PMID: 35080089, PMCID: PMC9232876, DOI: 10.1111/desc.13238.Peer-Reviewed Original ResearchConceptsCross-sectional pilot studyAge-related switchAmygdala reactivityPresent cross-sectional pilot studyPilot studyAnterior cingulate cortex activationDorsal anterior cingulate cortex (dACC) activationAmygdala connectivityCortex activationPrefrontal cortexDACC activationAmygdalaPrefrontal functionChildhoodPrefrontal engagementEmotional behaviorChildhood experiencesAdolescenceVentromedial PFCDACCOpposite effectBayesian network analysisActivationVmPFCReverse information flow
2014
Maternal Buffering of Human Amygdala-Prefrontal Circuitry During Childhood but Not During Adolescence
Gee DG, Gabard-Durnam L, Telzer EH, Humphreys KL, Goff B, Shapiro M, Flannery J, Lumian DS, Fareri DS, Caldera C, Tottenham N. Maternal Buffering of Human Amygdala-Prefrontal Circuitry During Childhood but Not During Adolescence. Psychological Science 2014, 25: 2067-2078. PMID: 25280904, PMCID: PMC4377225, DOI: 10.1177/0956797614550878.Peer-Reviewed Original ResearchConceptsAmygdala-prefrontal circuitryMaternal bufferingMaternal stimuliAmygdala-prefrontal connectivityMature connectivityAmygdala reactivityPotential mechanismsMaternal modulationChildhoodMother-child relationshipNeural mechanismsSensitive periodChildrenCaregiversMaternal influenceRegulatory influenceAdolescenceStimuliBehavioral regulationNeurocircuitryCircuitry
2013
A Developmental Shift from Positive to Negative Connectivity in Human Amygdala–Prefrontal Circuitry
Gee DG, Humphreys KL, Flannery J, Goff B, Telzer EH, Shapiro M, Hare TA, Bookheimer SY, Tottenham N. A Developmental Shift from Positive to Negative Connectivity in Human Amygdala–Prefrontal Circuitry. Journal Of Neuroscience 2013, 33: 4584-4593. PMID: 23467374, PMCID: PMC3670947, DOI: 10.1523/jneurosci.3446-12.2013.Peer-Reviewed Original ResearchConceptsAmygdala-prefrontal circuitryFunctional connectivityNegative connectivityAmygdala reactivityRecent human imagingParticipants 10 yearsTask-based functional magnetic resonance imagingNegative functional connectivityFunctional magnetic resonance imagingMagnetic resonance imagingAmygdala-prefrontal connectivityAmygdala-cortical connectivityAnxiety-related disordersFrontoamygdala circuitryAnimal studiesReciprocal connectionsResonance imagingTracing studyPositive connectivityAdolescent periodEarly childhoodNeurobiological basisEmotional behaviorPresent studyDevelopmental changes
2011
Altered age-related trajectories of amygdala-prefrontal circuitry in adolescents at clinical high risk for psychosis: A preliminary study
Gee DG, Karlsgodt KH, van Erp TG, Bearden CE, Lieberman MD, Belger A, Perkins DO, Olvet DM, Cornblatt BA, Constable T, Woods SW, Addington J, Cadenhead KS, McGlashan TH, Seidman LJ, Tsuang MT, Walker EF, Cannon TD, Consortium O. Altered age-related trajectories of amygdala-prefrontal circuitry in adolescents at clinical high risk for psychosis: A preliminary study. Schizophrenia Research 2011, 134: 1-9. PMID: 22056201, PMCID: PMC3245800, DOI: 10.1016/j.schres.2011.10.005.Peer-Reviewed Original ResearchConceptsClinical high riskFunctional connectivityPrefrontal cortexCHR adolescentsHigh riskAmygdala-prefrontal functional connectivityAmygdala-prefrontal circuitryCross-sectional analysisPsychophysiological interaction analysisVLPFC activationIllness onsetAge-related trajectoriesRisk syndromeVentrolateral prefrontal cortexInteraction of ageOvert psychosisAge-related variationsPsychosisAmygdala reactivityBrain connectivityFunctional activationAmygdalaCortexLater deficitsFMRI task