2024
Applying fetal, infant, and toddler (FIT) neuroimaging to understand mental health
Spann M, Scheinost D. Applying fetal, infant, and toddler (FIT) neuroimaging to understand mental health. Neuropsychopharmacology 2024, 1-2. PMID: 39117902, DOI: 10.1038/s41386-024-01957-5.Peer-Reviewed Original ResearchDevelopmental trajectories of the default mode, frontoparietal, and salience networks from the third trimester through the newborn period
Scheinost D, Chang J, Brennan-Wydra E, Lacadie C, Constable R, Chawarska K, Ment L. Developmental trajectories of the default mode, frontoparietal, and salience networks from the third trimester through the newborn period. Imaging Neuroscience 2024, 2: 1-16. DOI: 10.1162/imag_a_00201.Peer-Reviewed Original ResearchFronto-parietalDevelopmental trajectoriesImpact of maternal mental healthResting-state functional MRIWeeks postmenstrual ageInter-network connectivityIntra-network connectivityMaternal stress levelsMaternal mental healthPostmenstrual ageSalience networkFunctional MRINeurobehavioral disordersNeurodevelopmental disordersDMNMental healthThird trimesterConnectivity measuresSalienceConnectivity valuesEdge-centric network control on the human brain structural network
Sun H, Rosenblatt M, Dadashkarimi J, Rodriguez R, Tejavibulya L, Scheinost D. Edge-centric network control on the human brain structural network. Imaging Neuroscience 2024, 2: 1-15. DOI: 10.1162/imag_a_00191.Peer-Reviewed Original ResearchHuman brain structural networksNetwork control theoryEdge controlWhole-brain networksHuman Connectome ProjectDiffusion MRI dataWhite matter connectivityConnectome ProjectBrain dynamicsExecutive functionBrain structural networksBrain network connectivityBrain connectivityFunctional connectomeState transitionsTransitionEnergy patternsTheory modelBrain energy consumptionDynamic processStructural networkStateNetwork control mechanismsCognitive statesNetwork pairsThe brain structure, inflammatory, and genetic mechanisms mediate the association between physical frailty and depression
Jiang R, Noble S, Rosenblatt M, Dai W, Ye J, Liu S, Qi S, Calhoun V, Sui J, Scheinost D. The brain structure, inflammatory, and genetic mechanisms mediate the association between physical frailty and depression. Nature Communications 2024, 15: 4411. PMID: 38782943, PMCID: PMC11116547, DOI: 10.1038/s41467-024-48827-8.Peer-Reviewed Original ResearchConceptsIncident depressionPre-frailPhysical frailtyFrail individualsPopulation attributable fraction analysisRisk factors of depressionMendelian randomization analysisFactors of depressionPotential causal effectModifiable risk factorsNon-frail individualsCross-sectional studyEffect of frailtyHigher disease burdenUK BiobankRandomization analysisBrain volumeDepression casesDisease burdenFrailtyRegional brain volumesIncreased riskDepressionHigh riskFollow-upInvestigating Brain State Engagement Variability in Individuals With Opioid Use Disorder Using Naturalistic and Task-Based fMRI Data
Ye J, Mehta S, Peterson H, Ibrahim A, Saeed G, Linsky S, Kreinin I, Tsang S, Nwanaji-Enwerem U, Raso A, Yip S, Tokoglu F, Arora J, Constable R, Barry D, Redeker N, Yaggi H, Scheinost D. Investigating Brain State Engagement Variability in Individuals With Opioid Use Disorder Using Naturalistic and Task-Based fMRI Data. Biological Psychiatry 2024, 95: s6. DOI: 10.1016/j.biopsych.2024.02.022.Peer-Reviewed Original Research1. Multimodal Neuroimaging Findings in Individuals With Opioid Use Disorder
Mehta S, Peterson H, Ibrahim A, Saeed G, Linsky S, Kreinin I, Tsang S, Nwanaji-Enwerem U, Raso A, Arora J, Tokoglu F, Hahn C, Lacadie C, Greene A, Constable T, Barry D, Redeker N, Yaggi H, Scheinost D. 1. Multimodal Neuroimaging Findings in Individuals With Opioid Use Disorder. Biological Psychiatry 2024, 95: s99. DOI: 10.1016/j.biopsych.2024.02.236.Peer-Reviewed Original ResearchThe tip of the iceberg: A call to embrace anti-localizationism in human neuroscience research
Noble S, Curtiss J, Pessoa L, Scheinost D. The tip of the iceberg: A call to embrace anti-localizationism in human neuroscience research. Imaging Neuroscience 2024, 2: 1-10. DOI: 10.1162/imag_a_00138.Peer-Reviewed Original ResearchMapping Early Brain–Body Interactions: Associations of Fetal Heart Rate Variation with Newborn Brainstem, Hypothalamic, and Dorsal Anterior Cingulate Cortex Functional Connectivity
Pollatou A, Holland C, Stockton T, Peterson B, Scheinost D, Monk C, Spann M. Mapping Early Brain–Body Interactions: Associations of Fetal Heart Rate Variation with Newborn Brainstem, Hypothalamic, and Dorsal Anterior Cingulate Cortex Functional Connectivity. Journal Of Neuroscience 2024, 44: e2363232024. PMID: 38604780, PMCID: PMC11140686, DOI: 10.1523/jneurosci.2363-23.2024.Peer-Reviewed Original ResearchFetal heart rate indicesDorsal anterior cingulate cortexAutonomic nervous systemDorsal anterior cingulate cortex functional connectivityFetal HRHeart rate variabilityBrain regionsFetal heart rate variationWeeks of postmenstrual ageAutonomic nervous system developmentFetal autonomic nervous systemFetal heart rate variabilityAutonomic regulationHeart rate indicesFetal heart rateNervous systemFunctional connectivityHeart rateAnterior cingulate cortex functional connectivityAnterior cingulate cortexChildren's language abilitiesFetal actocardiographInfant brainstemPostmenstrual ageWeeks gestationBrain states as wave-like motifs
Foster M, Scheinost D. Brain states as wave-like motifs. Trends In Cognitive Sciences 2024, 28: 492-503. PMID: 38582654, DOI: 10.1016/j.tics.2024.03.004.Peer-Reviewed Original ResearchData leakage inflates prediction performance in connectome-based machine learning models
Rosenblatt M, Tejavibulya L, Jiang R, Noble S, Scheinost D. Data leakage inflates prediction performance in connectome-based machine learning models. Nature Communications 2024, 15: 1829. PMID: 38418819, PMCID: PMC10901797, DOI: 10.1038/s41467-024-46150-w.Peer-Reviewed Original ResearchRescuing missing data in connectome-based predictive modeling
Liang Q, Jiang R, Adkinson B, Rosenblatt M, Mehta S, Foster M, Dong S, You C, Negahban S, Zhou H, Chang J, Scheinost D. Rescuing missing data in connectome-based predictive modeling. Imaging Neuroscience 2024, 2: 1-16. DOI: 10.1162/imag_a_00071.Peer-Reviewed Original ResearchExperiences of Stigma and Discrimination Compounded by Intersecting Identities among Individuals Receiving Medication for Opioid Use Disorder.
Nwanaji-Enwerem U, Redeker N, O'Connell M, Barry D, Iheanacho T, Knobf T, Scheinost D, Wang K, Yaggi K, Sadler L. Experiences of Stigma and Discrimination Compounded by Intersecting Identities among Individuals Receiving Medication for Opioid Use Disorder. Journal Of Health Care For The Poor And Underserved 2024, 35: 94-115. PMID: 38661862, DOI: 10.1353/hpu.2024.a919810.Peer-Reviewed Original ResearchOpioid use disorderExperiences of stigmaIndividuals experience stigmaMarginalized social positionsIdentity of peopleUse disorderIntersectional identitiesMarginalized identitiesSupport interventionsSocial positionQualitative findingsStigmaNegative experiencesNortheast United StatesUnited StatesImprove outcomesIdentityTreatment centersMOUDIndividual vulnerabilityMedicationPeopleDiscriminationIndividualsCorrection: The effects of experience of discrimination and acculturation during pregnancy on the developing offspring brain
Spann M, Alleyne K, Holland C, Davids A, Pierre-Louis A, Bang C, Oyeneye V, Kiflom R, Shea E, Cheng B, Peterson B, Monk C, Scheinost D. Correction: The effects of experience of discrimination and acculturation during pregnancy on the developing offspring brain. Neuropsychopharmacology 2024, 49: 765-765. PMID: 38212444, PMCID: PMC10876701, DOI: 10.1038/s41386-024-01798-2.Peer-Reviewed Original Research
2023
Autism spectrum disorder-specific changes in white matter connectome edge density based on functionally defined nodes
Weber C, Lake E, Haider S, Mozayan A, Bobba P, Mukherjee P, Scheinost D, Constable R, Ment L, Payabvash S. Autism spectrum disorder-specific changes in white matter connectome edge density based on functionally defined nodes. Frontiers In Neuroscience 2023, 17: 1285396. PMID: 38075286, PMCID: PMC10702224, DOI: 10.3389/fnins.2023.1285396.Peer-Reviewed Original ResearchWhite matterPositive symptom correlationAutism spectrum disorderSymptom severity scoresBetween-group differencesAbnormal connectivity patternsCortical nodesVoxel-wise analysisDiffusion tensor imagingSeverity scoreWM fiber tractsSymptom correlationClinical dataConnectome disruptionConnectome changesEarly changesCortical regionsInfantsED reductionWM disruptionDisorder-specific changesTensor imagingFunctional imagingFiber tractsProbabilistic tractography“It’s all connected:” A mixed methods study of insomnia, stigma, and discrimination among individuals on medication for opioid use disorder
Nwanaji-Enwerem U, Sadler L, O'Connell M, Barry D, Knobf T, Jeon S, Scheinost D, Yaggi K, Redeker N. “It’s all connected:” A mixed methods study of insomnia, stigma, and discrimination among individuals on medication for opioid use disorder. Sleep Health 2023, 10: 31-40. PMID: 37980246, DOI: 10.1016/j.sleh.2023.09.004.Peer-Reviewed Original ResearchThe effects of experience of discrimination and acculturation during pregnancy on the developing offspring brain
Spann M, Alleyne K, Holland C, Davids A, Pierre-Louis A, Bang C, Oyeneye V, Kiflom R, Shea E, Cheng B, Peterson B, Monk C, Scheinost D. The effects of experience of discrimination and acculturation during pregnancy on the developing offspring brain. Neuropsychopharmacology 2023, 49: 476-485. PMID: 37968451, PMCID: PMC10724278, DOI: 10.1038/s41386-023-01765-3.Peer-Reviewed Original Research
2022
The Art, Science, and Secrets of Scanning Young Children
Spann M, Wisnowski J, Group H, Ahtam B, Gao W, Huang H, Nebel M, Norton E, Ouyang M, Rajagopalan V, Riggins T, Saygin Z, Scott L, Smyser C, Thomason M, Wakschlag L, Smyser C, Fetal I, Ahmad S, Aydin E, Barkovich A, Berger-Jenkins E, Brick J, Bowman L, Camacho M, Lugo-Candelas C, Cusack R, DuBois J, Dufford A, Elison J, Ellis C, Ferradal S, Filippi C, Ford A, Fouladivanda M, Gaab N, Gano D, Ganz-Benjaminsen M, Ghetti S, Glenn O, Gomez M, Graham A, Hendrix C, Holland C, Humphreys K, Korom M, Kosakowski H, Li G, Manessis A, Nolvi S, Pineda R, Pollatou A, Rae C, Rasmussen J, Scheinost D, Shultz S, Simon-Martinez C, Madsen K, Sung S, Sylvester C, Turesky T, Vaughn K, Wagner L, Wang L, Warton F, Wilson S, Wintermark P, Wu Y, Yap P, Yates T, Yen E, Yu X, Zhu H, Zöllei L, Howell B, Dean D. The Art, Science, and Secrets of Scanning Young Children. Biological Psychiatry 2022, 93: 858-860. PMID: 36336497, PMCID: PMC10050222, DOI: 10.1016/j.biopsych.2022.09.025.Peer-Reviewed Original ResearchHypoconnectivity between anterior insula and amygdala associates with future vulnerabilities in social development in a neurodiverse sample of neonates
Scheinost D, Chang J, Lacadie C, Brennan-Wydra E, Foster R, Boxberger A, Macari S, Vernetti A, Constable RT, Ment LR, Chawarska K. Hypoconnectivity between anterior insula and amygdala associates with future vulnerabilities in social development in a neurodiverse sample of neonates. Scientific Reports 2022, 12: 16230. PMID: 36171268, PMCID: PMC9517994, DOI: 10.1038/s41598-022-20617-6.Peer-Reviewed Original ResearchConceptsFirst Year InventoryAnterior insulaFunctional connectivityMaternal mental health factorsLeft anterior insulaState functional connectivityMental health factorsSubsample of participantsPostmenstrual ageSalience networkFamily historySocial domainsNeural circuitryAutismSocial behaviorBrain imagingHigher likelihoodInsulaSocial developmentHypoconnectivityExploratory analysisThird trimesterFuture onsetHealth factorsRisk scoreA graph theory neuroimaging approach to distinguish the depression of bipolar disorder from major depressive disorder in adolescents and young adults
Goldman DA, Sankar A, Rich A, Kim JA, Pittman B, Constable RT, Scheinost D, Blumberg HP. A graph theory neuroimaging approach to distinguish the depression of bipolar disorder from major depressive disorder in adolescents and young adults. Journal Of Affective Disorders 2022, 319: 15-26. PMID: 36103935, PMCID: PMC9669784, DOI: 10.1016/j.jad.2022.09.016.Peer-Reviewed Original ResearchConceptsAdolescents/young adultsMajor depressive disorderDepressive disorderYoung adultsICD increasesBipolar disorderInterhemispheric functional connectivityFunctional connectivity differencesSeed-based analysisFunctional connectivity patternsSeed-based connectivityFunctional magnetic resonanceFunctional connectivity measuresBasal gangliaFunctional dysconnectivityIllness progressionTreatment strategiesClinical measuresEarly diagnosisHC groupTargeted treatmentConnectivity differencesSuicide thoughtsFunctional connectivityDeleterious treatmentAssociations between grip strength, brain structure, and mental health in > 40,000 participants from the UK Biobank
Jiang R, Westwater ML, Noble S, Rosenblatt M, Dai W, Qi S, Sui J, Calhoun VD, Scheinost D. Associations between grip strength, brain structure, and mental health in > 40,000 participants from the UK Biobank. BMC Medicine 2022, 20: 286. PMID: 36076200, PMCID: PMC9461129, DOI: 10.1186/s12916-022-02490-2.Peer-Reviewed Original ResearchConceptsGray matter volumeMental healthBrain structuresCognitive declineMatter volumeMental health outcomesHigher life satisfactionBetter mental healthBaseline grip strengthNeural correlatesCognitive functioningCognitive performanceBaseline neuroticismAnxiety symptomsBehavioral outcomesLife satisfactionMediation analysisNeuroimaging datasetsTemporal cortexOlder adultsLinear mixed effects modelsSubcortical regionsFinancial satisfactionLongitudinal dataGrip strength