2023
Predicting depressed and elevated mood symptomatology in bipolar disorder using brain functional connectomes
Sankar A, Shen X, Colic L, Goldman D, Villa L, Kim J, Pittman B, Scheinost D, Constable R, Blumberg H. Predicting depressed and elevated mood symptomatology in bipolar disorder using brain functional connectomes. Psychological Medicine 2023, 53: 6656-6665. PMID: 36891769, PMCID: PMC10491744, DOI: 10.1017/s003329172300003x.Peer-Reviewed Original ResearchBipolar disorderYoung Mania Rating ScaleMania Rating ScaleFunctional connectomeBrain functional connectomeSymptom scoresHamilton DepressionMagnetic resonance imaging dataEmotion processing taskMood symptomatologyRating ScaleFunctional magnetic resonance imaging (fMRI) dataConnectomeAdultsImaging dataIndependent samplesPredictive abilitySymptomatology
2019
There is no single functional atlas even for a single individual: Functional parcel definitions change with task
Salehi M, Greene AS, Karbasi A, Shen X, Scheinost D, Constable RT. There is no single functional atlas even for a single individual: Functional parcel definitions change with task. NeuroImage 2019, 208: 116366. PMID: 31740342, DOI: 10.1016/j.neuroimage.2019.116366.Peer-Reviewed Original Research
2014
Coupled Intrinsic Connectivity Distribution Analysis: A Method for Exploratory Connectivity Analysis of Paired fMRI Data
Scheinost D, Shen X, Finn E, Sinha R, Constable RT, Papademetris X. Coupled Intrinsic Connectivity Distribution Analysis: A Method for Exploratory Connectivity Analysis of Paired fMRI Data. PLOS ONE 2014, 9: e93544. PMID: 24676034, PMCID: PMC3968179, DOI: 10.1371/journal.pone.0093544.Peer-Reviewed Original ResearchConceptsHealthy controlsIntrinsic connectivity distributionCocaine-dependent subjectsResting-state scansSeed-based analysisConnectivity analysisSimilar brain regionsBasic neuroscience researchMagnetic resonance imaging dataPsychiatric diseasesVoxel-based resultsConnectivity differencesBrain regionsClinical toolFunctional changesFunctional magnetic resonance imaging (fMRI) dataScansVoxel-based methodConnectivity approachNeuroscience researchConnectivity data
2013
Disruption of Functional Networks in Dyslexia: A Whole-Brain, Data-Driven Analysis of Connectivity
Finn ES, Shen X, Holahan JM, Scheinost D, Lacadie C, Papademetris X, Shaywitz SE, Shaywitz BA, Constable RT. Disruption of Functional Networks in Dyslexia: A Whole-Brain, Data-Driven Analysis of Connectivity. Biological Psychiatry 2013, 76: 397-404. PMID: 24124929, PMCID: PMC3984371, DOI: 10.1016/j.biopsych.2013.08.031.Peer-Reviewed Original ResearchConceptsFunctional connectivity analysisVisual word form areaConnectivity analysisWord form areaNon-impaired readersFunctional magnetic resonance imaging (fMRI) dataInferior frontal gyrusWhole-brain functional connectivity analysisAnterior language regionsVisual association areasWhole-brain connectivityAdult readersNeural basisImportance of synchronyFrontal gyrusSuccessful readingVisual stimuliLanguage regionsAttention areasBrain networksDiverse brain regionsMagnetic resonance imaging dataVisual informationDyslexiaVisual properties
2012
Real-time fMRI biofeedback targeting the orbitofrontal cortex for contamination anxiety.
Hampson M, Stoica T, Saksa J, Scheinost D, Qiu M, Bhawnani J, Pittenger C, Papademetris X, Constable T. Real-time fMRI biofeedback targeting the orbitofrontal cortex for contamination anxiety. Journal Of Visualized Experiments 2012 PMID: 22297729, PMCID: PMC3462579, DOI: 10.3791/3535.Peer-Reviewed Original ResearchConceptsObsessive-compulsive disorderOrbitofrontal cortexBrain areasContamination anxietySymptom severityQuarter of patientsSpecific brain areasClinical improvementControl subjectsClinical changesMagnetic resonance imaging dataHealthy subjectsPsychiatric disordersTherapeutic interventionsFunctional magnetic resonance imaging (fMRI) dataBrain regionsObsessive-compulsive symptomsBrain functionTraining subjectsOCD symptom severityBiofeedback interventionConsistent findingCortexBiofeedback trainingBiofeedback
2011
Biofeedback of Real-Time Functional Magnetic Resonance Imaging Data from the Supplementary Motor Area Reduces Functional Connectivity to Subcortical Regions
Hampson M, Scheinost D, Qiu M, Bhawnani J, Lacadie CM, Leckman JF, Constable RT, Papademetris X. Biofeedback of Real-Time Functional Magnetic Resonance Imaging Data from the Supplementary Motor Area Reduces Functional Connectivity to Subcortical Regions. Brain Connectivity 2011, 1: 91-98. PMID: 22432958, PMCID: PMC3621512, DOI: 10.1089/brain.2011.0002.Peer-Reviewed Original ResearchConceptsSupplementary motor areaReal-time functional magnetic resonanceFunctional connectivityTourette syndromeFunctional magnetic resonanceMotor areaSubcortical regionsBiofeedback sessionsState functional connectivityTic symptomsMagnetic resonance imaging dataHealthy subjectsTS patientsMagnetic resonanceBrain areasBiofeedbackFunctional magnetic resonance imaging (fMRI) dataFurther studiesSignificant increaseAberrant dynamicsSubjectsRecent studiesImaging dataSessionsPatients