2022
Associations between grip strength, brain structure, and mental health in > 40,000 participants from the UK Biobank
Jiang R, Westwater ML, Noble S, Rosenblatt M, Dai W, Qi S, Sui J, Calhoun VD, Scheinost D. Associations between grip strength, brain structure, and mental health in > 40,000 participants from the UK Biobank. BMC Medicine 2022, 20: 286. PMID: 36076200, PMCID: PMC9461129, DOI: 10.1186/s12916-022-02490-2.Peer-Reviewed Original ResearchConceptsGray matter volumeMental healthBrain structuresCognitive declineMatter volumeMental health outcomesHigher life satisfactionBetter mental healthBaseline grip strengthNeural correlatesCognitive functioningCognitive performanceBaseline neuroticismAnxiety symptomsBehavioral outcomesLife satisfactionMediation analysisNeuroimaging datasetsTemporal cortexOlder adultsLinear mixed effects modelsSubcortical regionsFinancial satisfactionLongitudinal dataGrip strength
2021
Functional connectivity during frustration: a preliminary study of predictive modeling of irritability in youth
Scheinost D, Dadashkarimi J, Finn ES, Wambach CG, MacGillivray C, Roule AL, Niendam TA, Pine DS, Brotman MA, Leibenluft E, Tseng WL. Functional connectivity during frustration: a preliminary study of predictive modeling of irritability in youth. Neuropsychopharmacology 2021, 46: 1300-1306. PMID: 33479511, PMCID: PMC8134471, DOI: 10.1038/s41386-020-00954-8.Peer-Reviewed Original ResearchConceptsFunctional connectivityAttention-deficit/hyperactivity disorderCognitive flexibility taskDisruptive mood dysregulation disorderAffective Reactivity IndexLevels of irritabilityPreliminary fMRI studyCognitive flexibilityFlexibility taskIndividual differencesTransdiagnostic sampleFrontal networkFMRI studyHyperactivity disorderTask difficultyNeural mechanismsParent reportAnxiety symptomsSalience networkAnxiety disordersFrustrative nonrewardDimensional measuresPreliminary evidenceReactivity indexChild psychiatry