Neural correlates of preparatory and regulatory control over positive and negative emotion
Seo D, Olman CA, Haut KM, Sinha R, MacDonald AW, Patrick CJ. Neural correlates of preparatory and regulatory control over positive and negative emotion. Social Cognitive And Affective Neuroscience 2013, 9: 494-504. PMID: 23887812, PMCID: PMC3989138, DOI: 10.1093/scan/nst115.Peer-Reviewed Original ResearchConceptsLateral prefrontal cortexEmotion regulationPrefrontal cortexGreater activationBrain activityCingulate cortexBilateral anterior prefrontal cortexRight lateral prefrontal cortexNegative emotion regulationActive emotion regulationCommon brain regionsAnterior prefrontal cortexVentromedial prefrontal cortexDorsomedial prefrontal cortexNegative emotional statesInferior parietal lobeFunctional magnetic resonanceBilateral dorsomedial prefrontal cortexPosterior cingulate cortexAnterior cingulate cortexMain effectRight precentral gyrusEmotional valencePositive emotionsNegative emotionsDisrupted Ventromedial Prefrontal Function, Alcohol Craving, and Subsequent Relapse Risk
Seo D, Lacadie CM, Tuit K, Hong KI, Constable RT, Sinha R. Disrupted Ventromedial Prefrontal Function, Alcohol Craving, and Subsequent Relapse Risk. JAMA Psychiatry 2013, 70: 727-739. PMID: 23636842, PMCID: PMC3788824, DOI: 10.1001/jamapsychiatry.2013.762.Peer-Reviewed Original ResearchConceptsHealthy control subjectsAD patientsControl subjectsInpatient treatmentAlcohol cravingAlcohol cuesBrain responsesRelapse riskAlcohol relapseHospital-based research unitAnterior cingulate cortex activationAlcohol-related cuesCommunity mental health centerVentromedial prefrontal functionChronic relapsing illnessVentromedial prefrontal cortexStress-induced cravingAbstinent alcohol-dependent patientsFunctional magnetic resonanceMental health centersAlcohol-dependent patientsSubsequent relapse riskNeural correlatesNeutral trialsHazard ratio