2023
Comparative Effectiveness of Anti-TNF in Combination With Low-Dose Methotrexate vs Anti-TNF Monotherapy in Pediatric Crohn’s Disease: A Pragmatic Randomized Trial
Kappelman M, Wohl D, Herfarth H, Firestine A, Adler J, Ammoury R, Aronow J, Bass D, Bass J, Benkov K, Tobi C, Boccieri M, Boyle B, Brinkman W, Cabera J, Chun K, Colletti R, Dodds C, Dorsey J, Ebach D, Entrena E, Forrest C, Galanko J, Grunow J, Gulati A, Ivanova A, Jester T, Kaplan J, Kugathasan S, Kusek M, Leibowitz I, Linville T, Lipstein E, Margolis P, Minar P, Molle-Rios Z, Moses J, Olano K, Osaba L, Palomo P, Pappa H, Park K, Pashankar D, Pitch L, Robinson M, Samson C, Sandberg K, Schuchard J, Seid M, Shelly K, Steiner S, Strople J, Sullivan J, Tung J, Wali P, Zikry M, Weinberger M, Saeed S, Bousvaros A. Comparative Effectiveness of Anti-TNF in Combination With Low-Dose Methotrexate vs Anti-TNF Monotherapy in Pediatric Crohn’s Disease: A Pragmatic Randomized Trial. Gastroenterology 2023, 165: 149-161.e7. PMID: 37004887, PMCID: PMC10330864, DOI: 10.1053/j.gastro.2023.03.224.Peer-Reviewed Original ResearchConceptsPediatric Crohn's diseaseNecrosis factor inhibitorsPatient-reported outcomesAdverse eventsTreatment failureCombination therapyCrohn's diseaseSerious AEsFactor inhibitorsTumor necrosis factor inhibitorsAnti-drug antibody developmentAnti-TNF monotherapyCombination therapy armCrohn's disease therapyMethotrexate combination therapyTolerable safety profileLow-dose methotrexateMore adverse eventsSerious adverse eventsAnti-drug antibodiesPragmatic Randomized TrialDisease therapyLoss of responseOral methotrexateTherapy armUse, Durability, and Risks for Discontinuation of Initial and Subsequent Biologics in a Large Pediatric‐Onset IBD Cohort
Kaplan J, Liu C, King E, Bass J, Patel A, Tung J, Chen S, Lissoos T, Candela N, Saeed S, Colletti R, Network I, Adler J, Baron H, Cabrera J, Dorsey J, Dykes D, Ebach D, Garin‐Laflam M, Gold B, Grunow J, Higuchi L, Jester T, Lapsia S, Leibowitz I, Linvlle T, Morhardt T, Moses J, Moulton D, Nasiri‐Blomgren S, Niklinska‐Schirtz B, Ogunmola N, Palomo P, Park K, Pashankar D, Pasternak B, Radano M, Samson C, Sandberg K, Schaefer M, Shashidhar H, Steiner S, Sullivan J, Tomer G, Verstraete S. Use, Durability, and Risks for Discontinuation of Initial and Subsequent Biologics in a Large Pediatric‐Onset IBD Cohort. Journal Of Pediatric Gastroenterology And Nutrition 2023, 76: 566-575. PMID: 36804501, PMCID: PMC10097486, DOI: 10.1097/mpg.0000000000003734.Peer-Reviewed Original ResearchConceptsCrohn's diseaseUlcerative colitisLoss of responseFirst biologicSubsequent biologicsBiologic agentsBiologic medicationsBiologic treatmentAnti-tumor necrosis factor agentsUpper gastrointestinal tract involvementGastrointestinal tract involvementNecrosis factor agentsActive Crohn's diseaseFirst biologic agentIBD cohortInitial biologicSecond biologicTract involvementCorticosteroid useFactor agentsPediatric IBDBiologic initiationDisease courseUnivariate analysisSevere disease
2021
Use of Patient-Reported Outcomes Measurement Information System Pediatric Measures as Clinical Trial Endpoints: Experience from a Multicenter Pragmatic Trial in Children with Crohn’s Disease
Miller T, Schuchard J, Carle A, Forrest C, Kappelman M, Group T, Adler J, Ammoury R, Bass D, Bass J, Benkov K, Bousvaros A, Boyle B, Cabrera J, Colletti R, Dorsey J, Ebach D, Firestine A, Gulati A, Hoffenberg E, Jester T, Kaplan J, Kugathasan S, Kusek M, Leibowitz I, Linville T, Margolis P, Minar P, Rios Z, Moses J, Palomo P, Pappa H, Pashankar D, Saeed S, Samson C, Sandberg K, Steiner S, Strople J, Sullivan J, Tung J, Wali P. Use of Patient-Reported Outcomes Measurement Information System Pediatric Measures as Clinical Trial Endpoints: Experience from a Multicenter Pragmatic Trial in Children with Crohn’s Disease. The Journal Of Pediatrics 2021, 242: 86-92.e3. PMID: 34740588, PMCID: PMC8882140, DOI: 10.1016/j.jpeds.2021.10.053.Peer-Reviewed Original ResearchConceptsPROMIS pediatric measuresMulticenter pragmatic trialCrohn's diseasePediatric measuresClinical trialsDisease activityPain interferencePragmatic trialPediatric patient-reported outcome measuresPatient-reported outcome measuresLower PRO scoresOutcomes Measurement Information System (PROMIS) pediatric measuresPRO score changesSteroid-free remissionPediatric Crohn's diseaseChronic pediatric illnessPragmatic clinical trialsClinical trial endpointsUse of patientPediatric patientsStudy endpointClinical outcomesPRO scoresTrial endpointsPRO endpoints
2020
Continued Statural Growth in Older Adolescents and Young Adults With Crohn’s Disease and Ulcerative Colitis Beyond the Time of Expected Growth Plate Closure
Gupta N, Liu C, King E, Sylvester F, Lee D, Boyle B, Trauernicht A, Chen S, Colletti R, Adler J, Ali S, Al-Nimr A, Ayers T, Baron H, Beasley G, Benkov K, Cabrera J, Cho-Dorado M, Dancel L, Di Palma J, Dorsey J, Gulati A, Hellmann J, Higuchi L, Hoffenberg E, Israel E, Jester T, Kiparissi F, Konikoff M, Leibowitz I, Maheshwari A, Moulton D, Moses J, Ogunmola N, Palmadottir J, Pandey A, Pappa H, Pashankar D, Pasternak B, Patel A, Quiros J, Rountree C, Samson C, Sandberg K, Schoen B, Steiner S, Stephens M, Sudel B, Sullivan J, Suskind D, Tomer G, Tung J, Verstraete S. Continued Statural Growth in Older Adolescents and Young Adults With Crohn’s Disease and Ulcerative Colitis Beyond the Time of Expected Growth Plate Closure. Inflammatory Bowel Diseases 2020, 26: 1880-1889. PMID: 31968095, DOI: 10.1093/ibd/izz334.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseGrowth plate closureUlcerative colitisCrohn's diseaseAge 15 yearsPlate closureStatural growthHeight gainNutrition Examination SurveyFinal adult heightHeight velocity curvesTotal height gainBowel diseasePediatric patientsExamination SurveyPatient transitionsNational HealthAdult carePatientsDisease statusAdult heightDiseaseYoung adultsGrowth plateRadiographic closure
2017
Correlation of Erythrocyte Sedimentation Rate and C‐Reactive Protein With Pediatric Inflammatory Bowel Disease Activity
Alper A, Zhang L, Pashankar DS. Correlation of Erythrocyte Sedimentation Rate and C‐Reactive Protein With Pediatric Inflammatory Bowel Disease Activity. Journal Of Pediatric Gastroenterology And Nutrition 2017, 65: e25-e27. PMID: 27741061, DOI: 10.1097/mpg.0000000000001444.Peer-Reviewed Original ResearchConceptsErythrocyte sedimentation rateC-reactive proteinInflammatory bowel diseaseDisease activityCrohn's diseaseBowel diseaseCRP valuesInflammatory bowel disease activitySmall bowel Crohn's diseaseUlcerative colitis disease activityNormal erythrocyte sedimentation rateBowel disease activityRadiographic disease activityHistologic activitySedimentation rateUlcerative colitisDiseaseDiagnosisChildrenColitisActivityPrevalence and Patterns of Marijuana Use in Young Adults With Inflammatory Bowel Disease
Phatak UP, Rojas‐Velasquez D, Porto A, Pashankar DS. Prevalence and Patterns of Marijuana Use in Young Adults With Inflammatory Bowel Disease. Journal Of Pediatric Gastroenterology And Nutrition 2017, 64: 261-264. PMID: 27846066, DOI: 10.1097/mpg.0000000000001474.Peer-Reviewed Original ResearchConceptsInflammatory bowel diseaseBowel diseaseYoung adultsAdverse effectsMarijuana useNeuropsychiatric adverse effectsPediatric IBD clinicsHalf of patientsPossible adverse effectsIBD clinicIBD therapyAbdominal painDisease activityIBD symptomsPoor appetiteMedical therapySymptom reliefComplete reliefSymptom improvementPatientsNonusers of marijuanaUse of marijuanaAnonymous questionnaireMedical marijuanaLegalization of marijuana
2016
Calcific Pancreatitis in Children
Patel MG, Baker K, Phatak UP, Alper A, Pashankar DS. Calcific Pancreatitis in Children. Journal Of Pediatric Gastroenterology And Nutrition 2016, 62: e28-e29. PMID: 24979475, DOI: 10.1097/mpg.0000000000000470.Peer-Reviewed Original ResearchPrevalence and Clinical, Endoscopic, and Pathological Features of Duodenitis in Children
Alper A, Hardee S, Rojas‐Velasquez D, Escalera S, Morotti RA, Pashankar DS. Prevalence and Clinical, Endoscopic, and Pathological Features of Duodenitis in Children. Journal Of Pediatric Gastroenterology And Nutrition 2016, 62: 314-316. PMID: 26252915, PMCID: PMC4724230, DOI: 10.1097/mpg.0000000000000942.Peer-Reviewed Original ResearchConceptsAssociated gastritisEndoscopic appearancePathological featuresCeliac diseaseClinical diagnosisDiagnosis of duodenitisPositive celiac serologyInflammatory bowel diseaseHelicobacter pylori infectionPatient's clinical diagnosisCeliac serologyAbdominal painUpper endoscopyVillous changesBowel diseaseCommon indicationUlcerative colitisCommon etiologyCrohn's diseasePylori infectionPathology reportsDuodenitisCommon causeEndoscopic dataLarge cohort
2014
Histopathology of Duodenal Mucosal Lesions in Pediatric Patients with Inflammatory Bowel Disease: Statistical Analysis to Identify Distinctive Features
Hardee S, Alper A, Pashankar DS, Morotti RA. Histopathology of Duodenal Mucosal Lesions in Pediatric Patients with Inflammatory Bowel Disease: Statistical Analysis to Identify Distinctive Features. Pediatric And Developmental Pathology 2014, 17: 450-454. PMID: 25207874, DOI: 10.2350/14-07-1529-oa.1.Peer-Reviewed Original ResearchConceptsUpper gastrointestinal tractVillous bluntingIntraepithelial lymphocytesPediatric patientsDuodenal lesionsDifferent etiopathogenesisUlcerative colitisCrohn's diseaseInflammatory bowel disease patientsCases of duodenitisDuodenal mucosal lesionsBowel disease patientsInflammatory bowel diseasePresence of granulomasAge-matched controlsLamina propria eosinophilsKruskal-Wallis testingCeliac groupDuodenal pathologyDuodenitis casesAssociated gastritisBowel diseaseCrypt hyperplasiaMucosal lesionsPediatric population
2001
Effect of Long-term Omeprazole Treatment on Antral G and D Cells in Children
Pashankar D, Israel D, Jevon G, Buchan A. Effect of Long-term Omeprazole Treatment on Antral G and D Cells in Children. Journal Of Pediatric Gastroenterology And Nutrition 2001, 33: 537-542. PMID: 11740225, DOI: 10.1097/00005176-200111000-00005.Peer-Reviewed Original ResearchConceptsLong-term omeprazole therapyD cell numbersAge-matched control groupG-cell numberOmeprazole therapyControl groupD cellsEndoscopic antral biopsy specimensAge groupsLong-term omeprazole treatmentErosive reflux esophagitisAntral biopsy specimensEffect of omeprazoleSignificant increaseDifferent age groupsReflux esophagitisGastrin secretionOmeprazole administrationBiopsy specimensHealthy childrenOmeprazole treatmentParacrine mannerOmeprazoleAntral glandsTherapyJaundice in Older Children and Adolescents
Pashankar D, Schreiber R. Jaundice in Older Children and Adolescents. Pediatrics In Review 2001, 22: 219-226. PMID: 11435623, DOI: 10.1542/pir.22-7-219.Peer-Reviewed Original Research
2000
Life-threatening gastrointestinal hemorrhage due to juvenile polyposis
Pashankar D, Murphy J, Ostry A, Schreiber R. Life-threatening gastrointestinal hemorrhage due to juvenile polyposis. The American Journal Of Gastroenterology 2000, 95: 543. PMID: 10685766, DOI: 10.1111/j.1572-0241.2000.01783.x.Peer-Reviewed Original ResearchConceptsJuvenile polyposisGI hemorrhageLife-threatening gastrointestinal hemorrhageLife-threatening GI hemorrhageMassive lower GI hemorrhageLower GI hemorrhageSeverity of hemorrhageGastrointestinal hemorrhageIntraoperative colonoscopyRadiological evaluationHistological findingsPediatric populationTherapeutic optionsMultiple polypsRare conditionUnusual presentationDifferential diagnosisFamily historyHealthy boysHemorrhagePolyposisDiagnosisHemicolectomyLaparotomyColonoscopy
1999
Downhill esophageal varices.
Pashankar D, Jamieson D, Israel D. Downhill esophageal varices. Journal Of Pediatric Gastroenterology And Nutrition 1999, 29: 360-2. PMID: 10468008, DOI: 10.1097/00005176-199909000-00024.Peer-Reviewed Original Research
1997
Gastrostomy in children with Crohn’s disease
PASHANKAR D, ISRAEL D. Gastrostomy in children with Crohn’s disease. Archives Of Disease In Childhood 1997, 77: 368. PMID: 9389249, PMCID: PMC1717357, DOI: 10.1136/adc.77.4.368a.Peer-Reviewed Original Research