2024
Low Anti-Tumor Necrosis Factor Levels During Maintenance Phase Are Associated With Treatment Failure in Children With Crohn’s Disease
Moses J, Adler J, Saeed S, Firestine A, Galanko J, Ammoury R, Bass D, Bass J, Bastidas M, Benkov K, Bousvaros A, Cabrera J, Chun K, Dorsey J, Ebach D, Gulati A, Herfarth H, Ivanova A, Jester T, Kaplan J, Kusek M, Leibowitz I, Linville T, Margolis P, Minar P, Molle-Rios Z, Niklinska-Schirtz B, Olano K, Osaba L, Palomo P, Pashankar D, Pitch L, Samson C, Sandberg K, Steiner S, Strople J, Sullivan J, Tung J, Wali P, Wohl D, Zikry M, Boyle B, Kappelman M. Low Anti-Tumor Necrosis Factor Levels During Maintenance Phase Are Associated With Treatment Failure in Children With Crohn’s Disease. Inflammatory Bowel Diseases 2024, izae239. PMID: 39418336, DOI: 10.1093/ibd/izae239.Peer-Reviewed Original ResearchTherapeutic drug levelsPatients treated with adalimumabPatients treated with infliximabHigher drug levelsAnti-TNF levelsMedian drug levelsTreatment failureCombination therapyReduce treatment failureDrug levelsLD-MTXLow-dose oral methotrexateAssociated with treatment failureCrohn's diseaseMonotherapy to combination therapyRisk of treatment failureAnti-tumor necrosis factorEffects of combination therapyCombination therapy armMaintenance of remissionAssociated with reduced riskPediatric Crohn's diseasePost hoc analysisAdalimumab initiationMaintenance therapy
2004
Pharmacotherapy of constipation in children
Pashankar D, Tolia V. Pharmacotherapy of constipation in children. Journal Of Clinical Practice 2004, 1: 149-157. DOI: 10.2217/14750708.1.1.149.Peer-Reviewed Original ResearchLong-term maintenance therapyNew prokinetic agentThird of childrenHealth care providersFecal disimpactionFunctional constipationChildhood constipationMaintenance therapyProkinetic agentsNew laxativeConstipationObvious causeTeam approachLaxativesLong-term problemsBehavioral modificationChildrenEncopresisTreatmentCommon problemDisimpactionPharmacotherapyTherapyLactulose
2001
Omeprazole Maintenance Therapy for Gastroesophageal Reflux Disease After Failure of Fundoplication
Pashankar D, Blair G, Israel D. Omeprazole Maintenance Therapy for Gastroesophageal Reflux Disease After Failure of Fundoplication. Journal Of Pediatric Gastroenterology And Nutrition 2001, 32: 145-149. PMID: 11321383, DOI: 10.1097/00005176-200102000-00010.Peer-Reviewed Original ResearchConceptsSymptoms of GERGastroesophageal refluxGastroesophageal reflux diseaseReflux diseaseRecurrence of GERFailure of fundoplicationGrade II esophagitisLong-term omeprazoleOmeprazole maintenance therapySeverity of esophagitisClinical adverse effectsSevere gastroesophageal refluxSubsequent surgical interventionLong-term drugsBenign gastric polypsMaintenance therapyPeptic strictureEsophageal dilatationFurther surgeryHiatal herniaTherapeutic challengeSurgical interventionGastric polypsMean ageClinical assessmentOmeprazole Maintenance Therapy for Gastroesophageal Reflux Disease After Failure of Fundoplication
Pashankar D, Blair G, Israel D. Omeprazole Maintenance Therapy for Gastroesophageal Reflux Disease After Failure of Fundoplication. Journal Of Pediatric Gastroenterology And Nutrition 2001, 32: 145-149. DOI: 10.1002/j.1536-4801.2001.tb07234.x.Peer-Reviewed Original ResearchSymptoms of GERGastroesophageal refluxGastroesophageal reflux diseaseReflux diseaseRecurrence of GERFailure of fundoplicationGrade II esophagitisLong-term omeprazoleOmeprazole maintenance therapySeverity of esophagitisClinical adverse effectsSevere gastroesophageal refluxSubsequent surgical interventionLong-term drugsBenign gastric polypsBackground RecurrenceMaintenance therapyPeptic strictureEsophageal dilatationFurther surgeryHiatal herniaTherapeutic challengeSurgical interventionGastric polypsMean age