The temporal effects of topical NF-κB inhibition, in the in vivo prevention of bile-related oncogenic mRNA and miRNA phenotypes in murine hypopharyngeal mucosa: a preclinical model
Vageli DP, Kasle D, Doukas SG, Doukas PG, Sasaki CT. The temporal effects of topical NF-κB inhibition, in the in vivo prevention of bile-related oncogenic mRNA and miRNA phenotypes in murine hypopharyngeal mucosa: a preclinical model. Oncotarget 2020, 11: 3303-3314. PMID: 32934775, PMCID: PMC7476734, DOI: 10.18632/oncotarget.27706.Peer-Reviewed Original ResearchNF-κB inhibitorBAY 11NF-κB-related pathwaysPharmacological NF-κB inhibitorSquamous cell cancerPro-inflammatory effectsNF-κB inhibitionNF-κB activationOncogenic mRNAsAcidic bileTopical preBile refluxHypopharyngeal cancerCell cancerPreclinical modelsTopical administrationHypopharyngeal mucosaBile exposureVivo preventionTranslational explorationMiR-155MiR-21Oncogenic eventsMiRNA phenotypesPrevents overexpression