Laminin Immunostaining in Biopsies as a Useful Biomarker of Early Invasion in Actinic Cheilitis and Differential Diagnosis Between Actinic Cheilitis and Lip Cancer: New Insights
Vageli D, Doukas P, Zacharouli K, Kakanis V, Strataki M, Zioga A, Skoulakis C, Koukoulis G, Ioannou M. Laminin Immunostaining in Biopsies as a Useful Biomarker of Early Invasion in Actinic Cheilitis and Differential Diagnosis Between Actinic Cheilitis and Lip Cancer: New Insights. Head And Neck Pathology 2022, 17: 331-338. PMID: 36303015, PMCID: PMC10293497, DOI: 10.1007/s12105-022-01504-y.Peer-Reviewed Original ResearchConceptsHigh-grade epithelial dysplasiaActinic cheilitisEpithelial dysplasiaDifferential diagnosisSitu carcinomaBasement membraneEarly invasionLow-grade epithelial dysplasiaLaminin immunostainingLaminin expressionHistopathological differential diagnosisBackgroundSquamous cell carcinomaOral lesionsLip cancerCell carcinomaPrecancerous lesionsParabasal cellsPreclinical studiesNeoplastic invasionOral cavityUseful biomarkerCheilitisPatientsLSCCCarcinoma