2010
Mutations Disrupting Selenocysteine Formation Cause Progressive Cerebello-Cerebral Atrophy
Agamy O, Zeev B, Lev D, Marcus B, Fine D, Su D, Narkis G, Ofir R, Hoffmann C, Leshinsky-Silver E, Flusser H, Sivan S, Söll D, Lerman-Sagie T, Birk OS. Mutations Disrupting Selenocysteine Formation Cause Progressive Cerebello-Cerebral Atrophy. American Journal Of Human Genetics 2010, 87: 538-544. PMID: 20920667, PMCID: PMC2948803, DOI: 10.1016/j.ajhg.2010.09.007.Peer-Reviewed Original Research
2000
Antisense HEMA1 RNA Expression Inhibits Heme and Chlorophyll Biosynthesis in Arabidopsis1
Kumar A, Söll D. Antisense HEMA1 RNA Expression Inhibits Heme and Chlorophyll Biosynthesis in Arabidopsis1. Plant Physiology 2000, 122: 49-56. PMID: 10631248, PMCID: PMC58843, DOI: 10.1104/pp.122.1.49.Peer-Reviewed Original ResearchConceptsConstitutive cauliflower mosaic virus 35S promoterCauliflower mosaic virus 35S promoterTransgenic Arabidopsis plantsGlutamyl-tRNA reductaseBiosynthesis of tetrapyrrolesNormal growth conditionsLevels of chlorophyllFormation of ALAArabidopsis plantsChlorophyll biosynthesisHemA geneChlorophyll deficiencyGsa geneFirst enzymeGene expressionEnzymatic stepsSecond enzymeHeme synthesisPlantsReductase expressionChlorophyllGrowth conditionsBiosynthesisHemeGenes
1995
A novel root gravitropism mutant of Arabidopsis thaliana exhibiting altered auxin physiology
Simmons C, Migliaccio F, Masson P, Caspar T, Söll D. A novel root gravitropism mutant of Arabidopsis thaliana exhibiting altered auxin physiology. Physiologia Plantarum 1995, 93: 790-798. PMID: 11540162, DOI: 10.1111/j.1399-3054.1995.tb05133.x.Peer-Reviewed Original ResearchConceptsGravitropism mutantsPolar auxin transport inhibitorsWild-type rootsLateral root formationAuxin transport inhibitorsInsertional gene inactivationAuxin-resistant mutantsArabidopsis thalianaAuxin physiologyComplementation testsRoot gravitropismRoot hairsRGR1Gene inactivationRoot elongationWild typeMutantsHormone classesRoot formationDichlorophenoxyacetic acidVisible markersMendelian recessiveMap unitsTransport inhibitorsRoots
1993
The periplasmic dipeptide permease system transports 5-aminolevulinic acid in Escherichia coli
Verkamp E, Backman V, Björnsson J, Söll D, Eggertsson G. The periplasmic dipeptide permease system transports 5-aminolevulinic acid in Escherichia coli. Journal Of Bacteriology 1993, 175: 1452-1456. PMID: 8444807, PMCID: PMC193232, DOI: 10.1128/jb.175.5.1452-1456.1993.Peer-Reviewed Original ResearchConceptsDpp operonE. coli chromosomeEscherichia coliWild-type growthClasses of mutantsAbsence of ALAGenetic screenDpp mutationsColi chromosomeDpp transportALA biosynthesisFirst geneDipeptide transport systemAnaerobic growthChromosomal insertionOperonRecombinant plasmidTransport systemExogenous ALAALA uptakeE. coliNormal growthMutantsMutationsColi
1979
Regulation of biosynthesis of aminoacyl-transfer RNA synthetases and of transfer-RNA in Escherichia coli.
Morgan S, Larossa R, Cheung A, Low B, Söll D. Regulation of biosynthesis of aminoacyl-transfer RNA synthetases and of transfer-RNA in Escherichia coli. Biological Research 1979, 12: 415-26. PMID: 45219.Peer-Reviewed Original ResearchConceptsGlutaminyl-tRNA synthetaseLeucyl-tRNA synthetaseGlnR mutantRegulation of biosynthesisClasses of mutantsTemperature-resistant revertantsOperator-promoter regionAminoacyl-transfer RNA synthetasesStructural geneLeu genesRegulatory mutantsThermolabile leucyl-tRNA synthetaseMutantsResistant revertantsFormation of glutamineGlutamine synthetaseE. coli strainsEscherichia coliRNA synthetasesGenesSynthetaseElevated levelsRevertantsColi strainsGlnTRegulation of the biosynthesis of aminoacyl-transfer ribonucleic acid synthetases and of transfer ribonucleic acid in Escherichia coli. VI. Mutants with increased levels of glutaminyl-transfer ribonucleic acid synthetase and of glutamine transfer ribonucleic acid
Cheung A, Morgan S, Low K, Söll D. Regulation of the biosynthesis of aminoacyl-transfer ribonucleic acid synthetases and of transfer ribonucleic acid in Escherichia coli. VI. Mutants with increased levels of glutaminyl-transfer ribonucleic acid synthetase and of glutamine transfer ribonucleic acid. Journal Of Bacteriology 1979, 139: 176-184. PMID: 378954, PMCID: PMC216843, DOI: 10.1128/jb.139.1.176-184.1979.Peer-Reviewed Original ResearchConceptsTransfer ribonucleic acidAminoacyl-transfer ribonucleic acid synthetasesE. coli mapGlutaminyl-tRNA synthetaseRibonucleic acidTRNA-GlnStructural geneGenetic lociEscherichia coli strainsSpontaneous revertantsEscherichia coliParental strainThermolabile enzymeInteresting strainsColi strainsSynthetaseLociRevertantsEnzymeGlnMin 24GlnRStrainsTRNAMutantsGlutamyl-γ-methyl ester acts as a methionine analogue in Escherichia coli: analogue resistant mutants map at the metJ and metK loci
Kraus J, Soll D, Low K. Glutamyl-γ-methyl ester acts as a methionine analogue in Escherichia coli: analogue resistant mutants map at the metJ and metK loci. Genetics Research 1979, 33: 49-55. PMID: 383574, DOI: 10.1017/s0016672300018152.Peer-Reviewed Original ResearchRegulation of the biosynthesis of aminoacyl-tRNA synthetases and of tRNA in Escherichia coli
Theall G, Low K, Söll D. Regulation of the biosynthesis of aminoacyl-tRNA synthetases and of tRNA in Escherichia coli. Molecular Genetics And Genomics 1979, 169: 205-211. PMID: 375009, DOI: 10.1007/bf00271672.Peer-Reviewed Original Research
1978
Regulation of the Biosynthesis of Aminoacid:tRNA Ligases and of †RNA
Morgan S, Söll D. Regulation of the Biosynthesis of Aminoacid:tRNA Ligases and of †RNA. Progress In Nucleic Acid Research And Molecular Biology 1978, 21: 181-207. PMID: 358278, DOI: 10.1016/s0079-6603(08)60270-6.Peer-Reviewed Original ResearchMeSH KeywordsAmino Acyl-tRNA SynthetasesCellsChromosome MappingGenesGuanosine TetraphosphateMutationProkaryotic CellsRNA, TransferConceptsTRNA ligasesBiosynthetic enzymesAmino acid biosynthetic enzymesTranscription-translation systemE. coli DNA fragmentsRegulation of biosynthesisComplex regulation patternAmino acid restrictionRegulatory mutantsTRNA ligaseLigasesGene productsRegulation of levelsRegulation patternsBacterial systemsDNA fragmentsAminoacyl-tRNAProtein synthesisTRNACellular constituentsPhysiological responsesSingle aminoacidsRegulationBiosynthesisEnzyme
1977
Regulation of biosynthesis of aminoacyl-tRNA synthetases and of tRNA in Escherichia coli II. Isolation of regulatory mutants affecting leucyl-tRNA synthetase levels
LaRossa R, Vögeli G, Low K, Söll D. Regulation of biosynthesis of aminoacyl-tRNA synthetases and of tRNA in Escherichia coli II. Isolation of regulatory mutants affecting leucyl-tRNA synthetase levels. Journal Of Molecular Biology 1977, 117: 1033-1048. PMID: 342703, DOI: 10.1016/s0022-2836(77)80011-9.Peer-Reviewed Original ResearchConceptsLeucyl-tRNA synthetaseThermolabile leucyl-tRNA synthetaseRegulation of biosynthesisDistinct genetic lociAminoacyl-tRNA synthetasesEscherichia coli IIOperator-promoter regionStructural geneRegulatory mutantsGenetic lociEscherichia coli strainsSuch revertantsSpontaneous revertantsThermolabile enzymeLociSynthetaseColi strainsRevertantsSynthetase levelsLeuTRNAMutantsSynthetasesLeuXBiosynthesisRegulation of biosynthesis of aminoacyl-tRNA synthetases and of tRNA in Escherichia coli I. Isolation and characterization of a mutant with elevated levels of tRNAGln1
Morgan S, Körner A, Low K, Söll D. Regulation of biosynthesis of aminoacyl-tRNA synthetases and of tRNA in Escherichia coli I. Isolation and characterization of a mutant with elevated levels of tRNAGln1. Journal Of Molecular Biology 1977, 117: 1013-1031. PMID: 24122, DOI: 10.1016/s0022-2836(77)80010-7.Peer-Reviewed Original ResearchConceptsGlutaminyl-tRNA synthetaseAminoacyl-tRNA synthetasesRegulation of biosynthesisEscherichia coli strainsGlutamine synthetaseSpontaneous revertantsSynthetasesColi strainsMutantsSynthetaseElevated levelsRevertantsI. IsolationTRNABiosynthesisDuplicationSpeciesMutationsGlnTRegulationOverproductionIsolation
1975
Isolation and partial characterization of three Escherichia coli mutants with altered transfer ribonucleic acid methylases
Marinus M, Morris N, Söll D, Kwong T. Isolation and partial characterization of three Escherichia coli mutants with altered transfer ribonucleic acid methylases. Journal Of Bacteriology 1975, 122: 257-265. PMID: 1091626, PMCID: PMC235665, DOI: 10.1128/jb.122.1.257-265.1975.Peer-Reviewed Original ResearchConceptsE. coli genomeEscherichia coli mutantsWild-type cellsEscherichia coli KAbility of RNAColi genomeColi mutantsAmber mutationGenetic lociMutagenized cellsColi KMutant strainMutantsLambda phageTRNAS-adenosylmethioninePartial characterizationGenomeCellsCrude enzymeBiosynthesisMethylasesMethylaseLociRNA
1974
Isolation and Partial Characterization of a Temperature-Sensitive Escherichia coli Mutant with Altered Glutaminyl-Transfer Ribonucleic Acid Synthetase
Körner A, Magee B, Liska B, Low K, Adelberg E, Söll D. Isolation and Partial Characterization of a Temperature-Sensitive Escherichia coli Mutant with Altered Glutaminyl-Transfer Ribonucleic Acid Synthetase. Journal Of Bacteriology 1974, 120: 154-158. PMID: 4153616, PMCID: PMC245744, DOI: 10.1128/jb.120.1.154-158.1974.Peer-Reviewed Original Research
1971
Isolation and Partial Characterization of Temperature-Sensitive Escherichia coli Mutants with Altered Leucyl- and Seryl-Transfer Ribonucleic Acid Synthetases
Low B, Gates F, Goldstein T, Söll D. Isolation and Partial Characterization of Temperature-Sensitive Escherichia coli Mutants with Altered Leucyl- and Seryl-Transfer Ribonucleic Acid Synthetases. Journal Of Bacteriology 1971, 108: 742-750. PMID: 4942762, PMCID: PMC247134, DOI: 10.1128/jb.108.2.742-750.1971.Peer-Reviewed Original ResearchConceptsLeucyl-tRNA synthetaseTemperature-sensitive Escherichia coli mutantsCorresponding genetic lociEscherichia coli mutantsSeryl-tRNA synthetaseTemperature-sensitive mutantColi mutantsGenetic lociBranched-chain amino acidsEscherichia coliAmino acidsConditional growthSynthetaseMutantsPartial characterizationEnzyme