2001
Genomics-based identification of targets in pathogenic bacteria for potential therapeutic and diagnostic use
Raczniak G, Ibba M, Söll D. Genomics-based identification of targets in pathogenic bacteria for potential therapeutic and diagnostic use. Toxicology 2001, 160: 181-189. PMID: 11246138, DOI: 10.1016/s0300-483x(00)00454-6.Peer-Reviewed Original ResearchConceptsComplete microbial genome sequencesMicrobial genome sequencesFundamental biological processesPathogen-specific pathwaysAminoacyl-tRNA synthesisGenome sequenceBiochemical approachesMammalian hostsIdentification of targetsBiological processesNumber of pathogensProtein synthesisPharmaceutical exploitationSynthesis pathwayCertain pathwaysNovel targetPathogenic bacteriaEnzyme presentPathwayDiagnostic targetsCell viabilityKey processesGenomicsRecent advancesTarget
1998
Glutamyl-tRNAGln amidotransferase in Deinococcus radiodurans may be confined to asparagine biosynthesis
Curnow A, Tumbula D, Pelaschier J, Min B, Söll D. Glutamyl-tRNAGln amidotransferase in Deinococcus radiodurans may be confined to asparagine biosynthesis. Proceedings Of The National Academy Of Sciences Of The United States Of America 1998, 95: 12838-12843. PMID: 9789001, PMCID: PMC23620, DOI: 10.1073/pnas.95.22.12838.Peer-Reviewed Original ResearchConceptsDeinococcus radioduransD. radiodurans genomeRadiation-resistant bacterium Deinococcus radioduransBiosynthesis of asparagineGlutaminyl-tRNA synthetaseGlutamyl-tRNA synthetaseBacterium Deinococcus radioduransPresence of AsnRSAsparaginyl-tRNA synthetaseAspartyl-tRNA synthetaseAsn-tRNAAsparagine biosynthesisAsparaginyl-tRNAGenomic sequencesGln-tRNAAsparagine synthetaseBiochemical experimentsTransamidation activityGlutaminyl-tRNAProtein synthesisSingle enzymeSynthetaseRadioduransBiosynthesisGenes