1979
Regulation of biosynthesis of aminoacyl-transfer RNA synthetases and of transfer-RNA in Escherichia coli.
Morgan S, Larossa R, Cheung A, Low B, Söll D. Regulation of biosynthesis of aminoacyl-transfer RNA synthetases and of transfer-RNA in Escherichia coli. Biological Research 1979, 12: 415-26. PMID: 45219.Peer-Reviewed Original ResearchConceptsGlutaminyl-tRNA synthetaseLeucyl-tRNA synthetaseGlnR mutantRegulation of biosynthesisClasses of mutantsTemperature-resistant revertantsOperator-promoter regionAminoacyl-transfer RNA synthetasesStructural geneLeu genesRegulatory mutantsThermolabile leucyl-tRNA synthetaseMutantsResistant revertantsFormation of glutamineGlutamine synthetaseE. coli strainsEscherichia coliRNA synthetasesGenesSynthetaseElevated levelsRevertantsColi strainsGlnT
1978
Regulation of the Biosynthesis of Aminoacid:tRNA Ligases and of †RNA
Morgan S, Söll D. Regulation of the Biosynthesis of Aminoacid:tRNA Ligases and of †RNA. Progress In Nucleic Acid Research And Molecular Biology 1978, 21: 181-207. PMID: 358278, DOI: 10.1016/s0079-6603(08)60270-6.Peer-Reviewed Original ResearchConceptsTRNA ligasesBiosynthetic enzymesAmino acid biosynthetic enzymesTranscription-translation systemE. coli DNA fragmentsRegulation of biosynthesisComplex regulation patternAmino acid restrictionRegulatory mutantsTRNA ligaseLigasesGene productsRegulation of levelsRegulation patternsBacterial systemsDNA fragmentsAminoacyl-tRNAProtein synthesisTRNACellular constituentsPhysiological responsesSingle aminoacidsRegulationBiosynthesisEnzyme
1977
Regulation of biosynthesis of aminoacyl-tRNA synthetases and of tRNA in Escherichia coli II. Isolation of regulatory mutants affecting leucyl-tRNA synthetase levels
LaRossa R, Vögeli G, Low K, Söll D. Regulation of biosynthesis of aminoacyl-tRNA synthetases and of tRNA in Escherichia coli II. Isolation of regulatory mutants affecting leucyl-tRNA synthetase levels. Journal Of Molecular Biology 1977, 117: 1033-1048. PMID: 342703, DOI: 10.1016/s0022-2836(77)80011-9.Peer-Reviewed Original ResearchConceptsLeucyl-tRNA synthetaseThermolabile leucyl-tRNA synthetaseRegulation of biosynthesisDistinct genetic lociAminoacyl-tRNA synthetasesEscherichia coli IIOperator-promoter regionStructural geneRegulatory mutantsGenetic lociEscherichia coli strainsSuch revertantsSpontaneous revertantsThermolabile enzymeLociSynthetaseColi strainsRevertantsSynthetase levelsLeuTRNAMutantsSynthetasesLeuXBiosynthesisRegulation of biosynthesis of aminoacyl-tRNA synthetases and of tRNA in Escherichia coli III. Biochemical characterization of regulatory mutants affecting leucyl-tRNA synthetase levels
LaRossa R, Mao J, Low K, Söll D. Regulation of biosynthesis of aminoacyl-tRNA synthetases and of tRNA in Escherichia coli III. Biochemical characterization of regulatory mutants affecting leucyl-tRNA synthetase levels. Journal Of Molecular Biology 1977, 117: 1049-1059. PMID: 342704, DOI: 10.1016/s0022-2836(77)80012-0.Peer-Reviewed Original ResearchConceptsAminoacyl-tRNA synthetasesLeucyl-tRNA synthetaseProtein synthesisRegulation of biosynthesisEscherichia coli IIIIsoacceptor familiesIlv operonRegulatory mutantsSteady-state levelsAmount of tRNALeu operonBiochemical characterizationCellular concentrationSynthetasesEscherichia coliOperonControl elementsTRNASynthetaseSynthetase levelsMutationsDerepressionPpGppMutantsPppGpp
1971
Enzymatic Modification of Transfer RNA
Söll D. Enzymatic Modification of Transfer RNA. Science 1971, 173: 293-299. PMID: 4934576, DOI: 10.1126/science.173.3994.293.Peer-Reviewed Original ResearchConceptsTRNA-modifying enzymesTRNA moleculesTRNA genesTransfer RNAAmino acid biosynthesisParticular tRNA speciesNucleic acid-protein interactionsAminoacyl-tRNA synthetaseSimple selection procedureAmino acid acceptorPrecursor tRNAsActive tRNAMature tRNACellular processesTRNA speciesRegulatory mutantsAcid biosynthesisRNA precursorsProtein factorsIsoacceptor tRNAsDifferent amino acidsNucleotide sequencePolynucleotide levelBiological functionsTRNA