2007
Quantitative Phosphoproteome Profiling of Wnt3a-mediated Signaling Network Indicating the Involvement of Ribonucleoside-diphosphate Reductase M2 Subunit Phosphorylation at Residue Serine 20 in Canonical Wnt Signal Transduction*
Tang L, Deng N, Wang L, Dai J, Wang Z, Jiang X, Li S, Li L, Sheng Q, Wu D, Li L, Zeng R. Quantitative Phosphoproteome Profiling of Wnt3a-mediated Signaling Network Indicating the Involvement of Ribonucleoside-diphosphate Reductase M2 Subunit Phosphorylation at Residue Serine 20 in Canonical Wnt Signal Transduction*. Molecular & Cellular Proteomics 2007, 6: 1952-1967. PMID: 17693683, DOI: 10.1074/mcp.m700120-mcp200.Peer-Reviewed Original ResearchConceptsCanonical WntDifferential phosphoproteinsWnt3a stimulationMultiple post-translational modificationsCanonical Wnt signal transductionWnt signal transductionUnique phosphorylation sitesPost-translational modificationsInteraction network analysisStable isotopic formsCanonical Wnt signalingReporter gene assayInhibitor of WntPhosphorylation networksNovel phosphoproteinsExtracellular stimuliPhosphoproteome profilingPhosphorylation sitesSignaling networksPhosphorylation regulationProtein phosphorylationSignal transductionPhosphorylation changesRNA interferenceDownstream effectors
2000
Protein Phosphatase 2Cα Dephosphorylates Axin and Activates LEF-1-dependent Transcription*
Wu D, Strovel E, Sussman D. Protein Phosphatase 2Cα Dephosphorylates Axin and Activates LEF-1-dependent Transcription*. Journal Of Biological Chemistry 2000, 275: 2399-2403. PMID: 10644691, DOI: 10.1074/jbc.275.4.2399.Peer-Reviewed Original ResearchMeSH KeywordsAdaptor Proteins, Signal TransducingAnimalsAxin ProteinCOS CellsDishevelled ProteinsDNA-Binding ProteinsEnzyme ActivationJNK Mitogen-Activated Protein KinasesLymphoid Enhancer-Binding Factor 1Mitogen-Activated Protein KinasesPhosphoprotein PhosphatasesPhosphoproteinsPhosphorylationPrecipitin TestsProtein BindingProtein Phosphatase 2Protein Phosphatase 2CProteinsRepressor ProteinsSaccharomyces cerevisiae ProteinsSignal TransductionTranscription FactorsTranscriptional ActivationConceptsLEF-1-dependent transcriptionWnt signal transductionSignal transductionExpression of PP2CProtein phosphatase 2CalphaProtein phosphatase 2CαTwo-hybrid systemDishevelled gene familyReporter gene assayGene familyPositive regulatorCytoplasmic proteinsPP2CNegative regulatorAxinWnt-1Gene assayTranscriptionTransductionRegulatorSynergistic responseProteinExpressionDephosphorylationRepression