Electrochemical detection of DNA 3′-phosphatases based on surface-extended DNA nanotail strategy
Wu D, Li C, Hu X, Mao X, Li G. Electrochemical detection of DNA 3′-phosphatases based on surface-extended DNA nanotail strategy. Analytica Chimica Acta 2016, 924: 29-34. PMID: 27181641, DOI: 10.1016/j.aca.2016.04.013.Peer-Reviewed Original ResearchConceptsDNA 3'-phosphataseT4 polynucleotide kinase phosphatasePolynucleotide kinase phosphataseLow detection limitLong DNA strandsSubstrate DNACellular processesTerminal deoxynucleotidyl transferaseDNA probesDNA strandsGold electrodeDephosphorylation reactionsTerminal hydroxylElectrochemical detectionUltrasensitive detectionDetection limitDNAAnalytical performanceDeoxynucleotidyl transferaseSignal amplificationDrug discoveryDephosphorylationClinical diagnosticsSignal enhancementTdT