2010
Murine visceral leishmaniasis: IgM and polyclonal B‐cell activation lead to disease exacerbation
Deak E, Jayakumar A, Cho KW, Goldsmith‐Pestana K, Dondji B, Lambris JD, McMahon‐Pratt D. Murine visceral leishmaniasis: IgM and polyclonal B‐cell activation lead to disease exacerbation. European Journal Of Immunology 2010, 40: 1355-1368. PMID: 20213734, PMCID: PMC2944234, DOI: 10.1002/eji.200939455.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibodies, ProtozoanAntigen PresentationB-LymphocytesComplement C5aDisease ProgressionFemaleHypergammaglobulinemiaImmunity, InnateImmunization, PassiveImmunoglobulin GImmunoglobulin MInterleukin-10Leishmania infantumLeishmaniasis, VisceralLymph NodesLymphocyte ActivationLymphocyte DepletionMaleMiceMice, Inbred BALB CMice, TransgenicParasitemiaConceptsBALB/c miceC miceDisease exacerbationImmune responseVisceral leishmaniasisB cell-derived IL-10WT BALB/c miceB cell antigen presentationPolyclonal B cell activationAnti-Leishmania responseOngoing immune responseL. infantum infectionHuman visceral leishmaniasisBALB/cB cell expansionIntradermal infection modelB cell activationEstablishment of infectionElevated parasitemiaParasite visceralizationCytokine levelsIL-10Infantum infectionPassive transferAntigen presentation
2008
Intradermal NKT cell activation during DNA priming in heterologous prime‐boost vaccination enhances T cell responses and protection against Leishmania
Dondji B, Deak E, Goldsmith‐Pestana K, Perez‐Jimenez E, Esteban M, Miyake S, Yamamura T, McMahon‐Pratt D. Intradermal NKT cell activation during DNA priming in heterologous prime‐boost vaccination enhances T cell responses and protection against Leishmania. European Journal Of Immunology 2008, 38: 706-719. PMID: 18286565, PMCID: PMC3448375, DOI: 10.1002/eji.200737660.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsAntibody FormationAntigens, ProtozoanCD4-Positive T-LymphocytesCD8-Positive T-LymphocytesGalactosylceramidesGenetic VectorsGranzymesImmunity, CellularInterferon-gammaInterleukin-10Killer Cells, NaturalLeishmaniasisLymphocyte ActivationLymphocyte DepletionMiceMice, Inbred BALB CMice, Mutant StrainsNitric OxideProtozoan ProteinsSkinT-LymphocytesVaccinationVaccines, DNAVaccinia virusConceptsHeterologous prime-boost vaccinationPrime-boost vaccinationNKT cell activationCD8 T cellsT cellsCell activationVaccinated miceDNA primingActivated C-kinase (rLACK) antigensT cell immune responsesDevelopment of CD4Murine cutaneous leishmaniasisT cell responsesCell immune responsesElicit protective immunityIL-10Protective immunityImmune responseLeishmania homologueIFN-gammaAlphaGalCerCutaneous leishmaniasisVisceral leishmaniasisParasite burdenCell responses
2006
Immunogenicity of the P-8 amastigote antigen in the experimental model of canine visceral leishmaniasis
Carrillo E, Ahmed S, Goldsmith-Pestana K, Nieto J, Osorio Y, Travi B, Moreno J, McMahon-Pratt D. Immunogenicity of the P-8 amastigote antigen in the experimental model of canine visceral leishmaniasis. Vaccine 2006, 25: 1534-1543. PMID: 17178178, PMCID: PMC2571115, DOI: 10.1016/j.vaccine.2006.10.036.Peer-Reviewed Original ResearchConceptsSoluble Leishmania antigenAmastigote antigensImmune responseAmerican cutaneous leishmaniasis patientsTh1-like immune responseSoluble leishmanial antigenCutaneous leishmaniasis patientsIL-4 mRNAAppropriate immune responseCanine visceral leishmaniasisElicit appropriate immune responsesIdentification of LeishmaniaGeneral vaccinesLeishmanial antigensIL-10Leishmania antigenLeishmaniasis patientsSLA antigensTNF-alphaDisease manifestationsIFN-gammaMurine modelMouse modelVisceral leishmaniasisLeishmania infantum
1991
Leishmaniasis in Bahia, Brazil: evidence that Leishmania amazonensis produces a wide spectrum of clinical disease.
Barral A, Pedral-Sampaio D, Grimaldi G, Momen H, McMahon-Pratt D, de Jesus A, Almeida R, Badaro R, Barral-Netto M, Carvalho E, Johnson W. Leishmaniasis in Bahia, Brazil: evidence that Leishmania amazonensis produces a wide spectrum of clinical disease. American Journal Of Tropical Medicine And Hygiene 1991, 44: 536-46. PMID: 2063957, DOI: 10.4269/ajtmh.1991.44.536.Peer-Reviewed Original ResearchConceptsMucocutaneous leishmaniasisCutaneous leishmaniasisClinical presentationVisceral leishmaniasisCases of CLMonoclonal antibodiesLeishmania amazonensisCases of DCLL. amazonensis infectionDifferent clinical presentationsDifferent clinical formsDifferent Leishmania speciesAmazonensis infectionClinical groundsIndistinguishable clinical presentationDermal leishmaniasisSpecific monoclonal antibodiesClinical formsClinical diseaseLeishmanial diseaseL. chagasiWide spectrumLeishmania referenceLeishmaniasisL. amazonensisLeishmania donovani chagasi: new clinical variant of cutaneous leishmaniasis in Honduras
Ponce C, Ponce E, Morrison A, Cruz A, Kreutzer R, McMahon-Pratt D, Neva F. Leishmania donovani chagasi: new clinical variant of cutaneous leishmaniasis in Honduras. The Lancet 1991, 337: 67-70. PMID: 1670724, DOI: 10.1016/0140-6736(91)90734-7.Peer-Reviewed Original ResearchConceptsCutaneous leishmaniasisSkin lesionsEndemic visceral leishmaniasisMontenegro skin testNew clinical variantAtypical cutaneous leishmaniasisSkin testLaboratory criteriaClinical variantsVisceral leishmaniasisKala-azarBone marrowPatientsParasite isolatesLesionsMajor antigenLeishmaniasisLeishmania mexicanaUnusual formIsoenzyme analysisYearsMarrowAntigenChagasiMonths
1988
Purification and characterization of an 80-kilodalton membrane protein from Leishmania donovani
White A, McMahon-Pratt D. Purification and characterization of an 80-kilodalton membrane protein from Leishmania donovani. Infection And Immunity 1988, 56: 2385-2391. PMID: 3165961, PMCID: PMC259577, DOI: 10.1128/iai.56.9.2385-2391.1988.Peer-Reviewed Original Research
1987
Serodiagnostic assay for visceral leishmaniasis employing monoclonal antibodies
Jaffe C, McMahon-Pratt D. Serodiagnostic assay for visceral leishmaniasis employing monoclonal antibodies. Transactions Of The Royal Society Of Tropical Medicine And Hygiene 1987, 81: 587-594. PMID: 3445339, DOI: 10.1016/0035-9203(87)90418-4.Peer-Reviewed Original ResearchConceptsVisceral leishmaniasisMonoclonal antibodiesSerodiagnostic assaysVL seraParasite antigensChagas diseaseSystemic lupus erythematosusNon-endemic areasDifferent parasite antigensLeishmania antigenLupus erythematosusMucocutaneous leishmaniasisLepromatous leprosyNegative control seraPositive casesSpecies-specific monoclonal antibodiesNormal serumControl seraRapid diagnosisAntigenSerum dilutionSerumAntibodiesLeishmaniasisSpecific inhibition
1984
Production and characterization of species-specific monoclonal antibodies against Leishmania donovani for immunodiagnosis.
Jaffe C, Bennett E, Grimaldi G, McMahon-Pratt D. Production and characterization of species-specific monoclonal antibodies against Leishmania donovani for immunodiagnosis. The Journal Of Immunology 1984, 133: 440-7. PMID: 6373932, DOI: 10.4049/jimmunol.133.1.440.Peer-Reviewed Original ResearchConceptsMonoclonal antibodiesVisceral leishmaniasisSpecies-specific monoclonal antibodiesL. donovaniAntibody DAntigenic determinantsLeishmania donovaniKala-azar serumWestern blot analysisSpecies of LeishmaniaSerologic assaysEpidemiologic studiesClinical diagnosisWestern blotAntigenic moleculesProtein antigensRadioimmunoprecipitation analysisAntibodiesLeishmaniasisLeishmania speciesLeishmania stocksDonovaniMonoclonal antibody DBlot analysisAntigen