2019
- Vaccine-based therapiesPublic health interventionsMechanism of actionTreatment of cancerCurrent vaccinesDisease preventionVaccine developmentHealth interventionsInfectious diseasesVaccinationDrug addictionVaccinePreventionTreatmentDelivery systemHospitalizationAllergyAdjuvantTherapyIllnessCancerDiseaseCDC
2004
Does the Leishmania major paradigm of pathogenesis and protection hold for New World cutaneous leishmaniases or the visceral disease?
McMahon‐Pratt D, Alexander J. Does the Leishmania major paradigm of pathogenesis and protection hold for New World cutaneous leishmaniases or the visceral disease? Immunological Reviews 2004, 201: 206-224. PMID: 15361243, DOI: 10.1111/j.0105-2896.2004.00190.x.Peer-Reviewed Original ResearchConceptsMajor histocompatibility complex classDistinct Leishmania speciesLeishmania major infectionResolution of infectionT cell responsesT helper 1Histocompatibility complex classDifferent virulence factorsHost defense mechanismsMajor infectionVisceral diseaseHost macrophage cellsImmune mechanismsVisceral organsParasitic protozoaVaccine developmentCutaneous leishmaniasesSusceptibility/resistanceIntracellular pathogensGenus LeishmaniaControl of diseaseInfectionMacrophage cellsDiseaseLeishmania species
2001
Cellular trafficking in trypanosomatids: a new target for therapies?
Costa-Pinto D, Trindade L, McMahon-Pratt D, Traub-Cseko Y. Cellular trafficking in trypanosomatids: a new target for therapies? International Journal For Parasitology 2001, 31: 537-544. PMID: 11334939, DOI: 10.1016/s0020-7519(01)00145-x.Peer-Reviewed Original ResearchConceptsPathogenic trypanosomatidsTrafficking mechanismsLysosomal targetingCellular trafficking mechanismsPlethora of diseasesCellular traffickingTrypanosomatidsTargeting mechanismCysteine proteinasesBiological aspectsNew targetsCurrent knowledgeEfficient vaccineDisease controlTherapyBasic mechanismsTraffickingMechanismTargetParasitesVaccineProteinasesDiseaseTargeting
1992
Cutaneous Leishmaniasis: Review of 59 Cases Seen at the National Institutes of Health
Melby P, Kreutzer R, McMahon-Pratt D, Gam A, Neva F. Cutaneous Leishmaniasis: Review of 59 Cases Seen at the National Institutes of Health. Clinical Infectious Diseases 1992, 15: 924-937. PMID: 1457663, DOI: 10.1093/clind/15.6.924.Peer-Reviewed Original ResearchConceptsCutaneous leishmaniasisEndemic areasCutaneous diseaseGroup of patientsDiffuse cutaneous leishmaniasisNational InstituteDifferent endemic areasChronic relapsingFrequent international travelOptimal therapyClinical spectrumMultiple lesionsAmerican patientsLeishmaniasisPatientsLeishmania majorDiseaseLesionsEarly ageInternational travelU.S. residentsHealthRelapsingMajorityTherapy
1988
Biology of Leishmania and Leishmaniasis
Furtado T, Goihman-Yahr M, Marghescu S, Grimaldi G, David J, McMahon-Pratt D, Rothenberg A, Rosquete R, Avila-Millán E, Istúriz G, Viloria N, de Borges N, Carrasquero M, de Fernández B, Tapia F, de Albornoz M, Bretaña A, de Brito I, Urquiola G, Pereira J, Martín B, de Gómez M, de Román A, Lugo A, Convit J, Padilha-Gonçalves A, Vale E, Araújo M. Biology of Leishmania and Leishmaniasis. 1988, 782-800. DOI: 10.1007/978-3-642-83360-1_87.Commentaries, Editorials and LettersDifferent clinical manifestationsImmunological characterizationCulture of parasitesBiology of LeishmaniaClinical manifestationsReference centerInternational Reference CentreL. tropicaMonoclonal antibodiesParasite strainsElectron microscopic morphologyNew World LeishmaniaLeishmaniaIsoenzyme patternsBraziliensisDonovaniBiochemical methodsParasitesLeishmaniasisDisease
1985
Mucocutaneous leishmaniasis in Colombia: Leishmania braziliensis subspecies diversity.
Holguín A, D'Alessandro A, McMahon-Pratt D, Saravia N. Mucocutaneous leishmaniasis in Colombia: Leishmania braziliensis subspecies diversity. American Journal Of Tropical Medicine And Hygiene 1985, 34: 714-20. PMID: 4025684, DOI: 10.4269/ajtmh.1985.34.714.Peer-Reviewed Original ResearchConceptsMucocutaneous leishmaniasisLeishmania braziliensis braziliensisCutaneous manifestationsMucocutaneous diseaseMucocutaneous lesionsMucosal lesionsMetastatic developmentDisease formsEtiologic agentLeishmania braziliensisLeishmania isolatesLeishmaniasisLesionsBraziliensisSpecificity characteristicsParasitesPatientsDisease