2022
Subtyping intestinal metaplasia in patients with chronic atrophic gastritis: an interobserver variability study
Lerch JM, Pai RK, Brown I, Gill AJ, Jain D, Kővári B, Kushima R, Sheahan K, Slavik T, Srivastava A, Lauwers GY, Langner C. Subtyping intestinal metaplasia in patients with chronic atrophic gastritis: an interobserver variability study. Pathology 2022, 54: 262-268. PMID: 35221041, DOI: 10.1016/j.pathol.2021.12.288.Peer-Reviewed Original ResearchMeSH KeywordsBiopsyGastritis, AtrophicHumansMetaplasiaObserver VariationPrecancerous ConditionsStomach NeoplasmsConceptsGastric intestinal metaplasiaChronic atrophic gastritisAmerican Gastroenterological AssociationAtrophic gastritisIntestinal metaplasiaConsensus diagnosisInterobserver variabilityCurrent practice guidelinesExpert pathologistsSubstantial overall agreementHigh interobserver agreementHistological diagnosisGastrointestinal endoscopyGastroenterological AssociationPractice guidelinesGastric cancerBiopsy piecesMucosal surfacesClinical decisionLevel of agreementInterobserver agreementInterobserver variability studyEuropean SocietyPredominant patternKappa statistics
2021
Interobserver agreement of estimating the extent of intestinal metaplasia in patients with chronic atrophic gastritis
Lerch JM, Pai RK, Brown I, Gill AJ, Jain D, Kővári B, Kushima R, Sheahan K, Slavik T, Srivastava A, Lauwers GY, Langner C. Interobserver agreement of estimating the extent of intestinal metaplasia in patients with chronic atrophic gastritis. Virchows Archiv 2021, 480: 1277-1281. PMID: 34904185, PMCID: PMC9184363, DOI: 10.1007/s00428-021-03245-9.Peer-Reviewed Original ResearchConceptsGastric intestinal metaplasiaChronic atrophic gastritisIntraclass correlation coefficientInterobserver agreementAtrophic gastritisIntestinal metaplasiaExtensive gastric intestinal metaplasiaAlcian blue-periodic acid SchiffExpert gastrointestinal pathologistsHigh interobserver agreementLow diagnostic accuracyMetaplastic epitheliumAntrum biopsiesGastrointestinal pathologistsGastric cancerDiagnostic accuracyAcid-SchiffAB-PASExpert pathologistsSpearman correlationGastritisMetaplasiaPatientsPathologists
2020
Intestinal metaplasia around the gastroesophageal junction is frequently associated with antral reactive gastropathy: implications for carcinoma at the gastroesophageal junction
Vyas M, Celli R, Singh M, Patel N, Aslanian HR, Boffa D, Deng Y, Ciarleglio MM, Laine L, Jain D. Intestinal metaplasia around the gastroesophageal junction is frequently associated with antral reactive gastropathy: implications for carcinoma at the gastroesophageal junction. Human Pathology 2020, 105: 67-73. PMID: 32941964, PMCID: PMC11152084, DOI: 10.1016/j.humpath.2020.08.007.Peer-Reviewed Original ResearchConceptsNonsteroidal anti-inflammatory drugsBile refluxIntestinal metaplasiaReactive gastropathyGEJ regionMucosal injuryMucosal changesGastroesophageal junctionAntral intestinal metaplasiaDistal esophageal adenocarcinomaDetailed clinical historySex-matched patientsGastric antral biopsiesAnti-inflammatory drugsGastric bile refluxMucosal inflammationProximal stomachDistal esophagusMedication usePancreatic metaplasiaPathology databaseProximal gastricAntral biopsiesClinical historyGastric biopsies
2018
Gastric Adenocarcinoma of the Fundic Gland Type
Benedict MA, Lauwers GY, Jain D. Gastric Adenocarcinoma of the Fundic Gland Type. American Journal Of Clinical Pathology 2018, 149: 461-473. PMID: 29648578, DOI: 10.1093/ajcp/aqy019.Peer-Reviewed Original ResearchConceptsFundic gland typeGA-FGGastric adenocarcinomaParietal cellsEndoscopic mucosal resectionGeneral surgical pathologistsFeatures of malignancyChief cell differentiationGland typeDeeper invasionExtragastric spreadGastric atrophyLymphovascular invasionBenign courseIntestinal metaplasiaMucosal resectionNodal metastasisSurgical excisionChronic gastritisRare lesionsUncommon neoplasmHelicobacter infectionOxyntic mucosaSurgical pathologistsAdequate treatment
2014
Evaluation of Barrett Esophagus by Multiphoton Microscopy
Wong S, Nathanson M, Chen J, Jain D. Evaluation of Barrett Esophagus by Multiphoton Microscopy. Archives Of Pathology & Laboratory Medicine 2014, 138: 204-12. PMID: 24476518, PMCID: PMC4089503, DOI: 10.5858/arpa.2012-0675-oa.Peer-Reviewed Original ResearchMeSH KeywordsAdenine NucleotidesBarrett EsophagusBiopsyCardiaConnecticutEndoscopy, GastrointestinalEsophagogastric JunctionEsophagusGastric FundusGastric MucosaGoblet CellsHospitals, UniversityHumansLasersMaterials TestingMetaplasiaMicroscopy, Fluorescence, MultiphotonMucous MembranePoint-of-Care SystemsSpectroscopy, Near-InfraredConceptsDiagnosis of BEBarrett's esophagusGastroesophageal junctionGoblet cellsColumnar mucosaSquamous mucosaBiopsy specimensNormal esophageal squamous mucosaMPM imagingEndoscopy suiteIntestinal-type columnar epitheliumCardia-type mucosaRoutine upper endoscopyTissue blocksSurveillance of patientsRoutine histopathologic examinationNormal squamous mucosaType of mucosaEsophageal squamous mucosaFresh biopsy specimensMPM imagesSquamous epithelial cellsGastric fundic mucosaMultiphoton microscopyUpper endoscopy