2023
Focal nodular hyperplasia–like nodules arising in the setting of hepatic vascular disorders with portosystemic shunting show β-catenin activation
Umetsu S, Joseph N, Cho S, Morotti R, Deshpande V, Jain D, Kakar S. Focal nodular hyperplasia–like nodules arising in the setting of hepatic vascular disorders with portosystemic shunting show β-catenin activation. Human Pathology 2023, 142: 20-26. PMID: 37806391, DOI: 10.1016/j.humpath.2023.09.010.Peer-Reviewed Original ResearchMeSH KeywordsAdenoma, Liver CellBeta CateninCarcinoma, HepatocellularDiagnosis, DifferentialFocal Nodular HyperplasiaHumansLiver NeoplasmsVascular DiseasesConceptsHepatic vascular disordersFocal nodular hyperplasiaFNH-like nodulesHepatocellular adenomaVascular disordersHepatocellular carcinomaΒ-catenin activationPortosystemic shuntRegenerative nodulesFocal nodular hyperplasia-like nodulesPost-Fontan procedureGlutamine synthetase stainingAbernethy malformationLiver resectionPortosystemic shuntingHistologic featuresMalignant neoplasmsNodular lesionsVascular diseaseDuctular reactionNodular hyperplasiaNodular architectureHepatocellular nodulesBenign lesionsFibrous septaHepatocellular Adenoma: Report of 2 Cases That Highlight the Relevance of Phenotype-Genotype Correlation in the Pediatric Population
Jiao J, Finberg K, Jain D, Morotti R. Hepatocellular Adenoma: Report of 2 Cases That Highlight the Relevance of Phenotype-Genotype Correlation in the Pediatric Population. Pediatric And Developmental Pathology 2023, 26: 394-403. PMID: 37334553, DOI: 10.1177/10935266231175426.Peer-Reviewed Case Reports and Technical NotesMeSH KeywordsAdenoma, Liver CellAdolescentBeta CateninCarcinoma, HepatocellularChildGenotypeHedgehog ProteinsHumansLiver NeoplasmsMalePhenotypeConceptsHepatocellular adenomaPediatric populationInflammatory HCASonic hedgehog hepatocellular adenomasYoung type 3Maturity-onset diabetesInflammatory hepatocellular adenomaΒ-catenin-activated hepatocellular adenomaAbernethy malformationPhenotype-genotype correlationClinical historyHCA subtypesH-HCACase 2Case 1Type 3Pathological informationB-HCASubtypesFamily surveillanceLimited studiesMalesClinicopathologic characterization of hepatocellular adenomas in men: a multicenter experience
González I, Torbenson M, Sharifai N, Byrnes K, Chatterjee D, Kakar S, Yeh M, Wu T, Zhang X, Jain D. Clinicopathologic characterization of hepatocellular adenomas in men: a multicenter experience. Human Pathology 2023, 138: 24-33. PMID: 37245629, DOI: 10.1016/j.humpath.2023.05.010.Peer-Reviewed Original ResearchMeSH KeywordsAdenoma, Liver CellAdolescentAdultAgedBeta CateninBiopsyCarcinoma, HepatocellularChildFemaleHumansLiver NeoplasmsMaleMiddle AgedPrecancerous ConditionsYoung AdultConceptsHepatocellular adenomaHepatocellular carcinomaMalignant transformationMulticenter experienceMean ageWorld Health Organization classificationConcomitant hepatocellular carcinomaAndrogen receptor expressionBenign liver neoplasmUnclassified hepatocellular adenomaUncertain malignant potentialInflammatory hepatocellular adenomaΒ-catenin-activated hepatocellular adenomaClinicopathologic characterizationEntire cohortHCA casesCommon subtypeMalignant potentialOrganization classificationReproductive ageAllred score systemResection casesReceptor expressionHepatocellular neoplasmsLiver neoplasmsThe role of routine biopsy of the background liver in the management of hepatocellular carcinoma
Lee S, Ahmed M, Taddei T, Jain D. The role of routine biopsy of the background liver in the management of hepatocellular carcinoma. Human Pathology 2023, 138: 18-23. PMID: 37236406, DOI: 10.1016/j.humpath.2023.05.009.Peer-Reviewed Original ResearchMeSH KeywordsBiopsyCarcinoma, HepatocellularFemaleHumansLiver CirrhosisLiver NeoplasmsMaleMiddle AgedConceptsLiver biopsyEarly HCC stagesHepatocellular carcinoma managementLarge university hospitalSeparate biopsiesCirrhosis statusClinical characteristicsClinical suspicionMedian ageEarly diseasePathology databaseRoutine biopsyHCC stageBiopsy resultsHCC patientsParenchymal findingsUniversity HospitalBackground liverHepatocellular carcinomaNontumoral liverHCC biopsiesBiopsyPatientsCirrhosisLiver
2022
Alternative lengthening of telomeres in primary hepatic neoplasms
Yasir S, Thompson S, Chen Z, Knudson R, Knutson D, Kloft-Nelson S, Graham R, Jain D, Simon S, Wu T, Torbenson M. Alternative lengthening of telomeres in primary hepatic neoplasms. Human Pathology 2022, 131: 79-86. PMID: 36370823, PMCID: PMC10756352, DOI: 10.1016/j.humpath.2022.11.003.Peer-Reviewed Original ResearchConceptsPrimary hepatic neoplasmsPrimary hepatic angiosarcomaHepatocellular carcinomaHepatic neoplasmsHepatic angiosarcomaFibrolamellar carcinomaEpithelial tumorsNuclear pleomorphismFrequency of ALTStromal-epithelial tumorPrimary hepatic tumorsHepatocellular carcinoma componentMarked nuclear pleomorphismSoft tissue tumorsRare carcinosarcomaEmbryonal sarcomaEpithelioid hemangioendotheliomaDuct adenomaHilar cholangiocarcinomaCarcinoma componentHepatic adenomaHepatic tumorsTissue tumorsHepatocellular adenomaRhabdoid tumorProminent Pseudoacini in Focal Nodular Hyperplasia
Wang D, González IA, Russo PA, Jain D, Zhang X. Prominent Pseudoacini in Focal Nodular Hyperplasia. The American Journal Of Surgical Pathology 2022, 46: 1380-1385. PMID: 35749760, DOI: 10.1097/pas.0000000000001931.Peer-Reviewed Original ResearchConceptsFocal nodular hyperplasiaHepatocellular carcinomaNodular hyperplasiaFNH casesPotential diagnostic pitfallInspissated bileChronic cholestasisInitial biopsyPathologic featuresClinicopathologic correlationDiagnostic challengeNeedle biopsyDifferential diagnosisHepatocellular neoplasmsHepatocellular adenomaDiagnostic pitfallsMorphologic featuresLobular parenchymaStaining patternPseudoaciniBiliary transdifferentiationBiopsyHyperplasiaLesionsHepatocytes
2021
Pathogenic BRCA2 germline variants in combined hepatocellular‐cholangiocarcinoma
Li H, Zhang X, Finberg KE, Walther Z, Jain D, Gibson J. Pathogenic BRCA2 germline variants in combined hepatocellular‐cholangiocarcinoma. Pathology International 2021, 72: 138-140. PMID: 34808016, DOI: 10.1111/pin.13188.Peer-Reviewed Original ResearchHepatocellular Carcinoma
Jain A, Mazer B, Deng Y, Ciarleglio M, Jain D, Taddei T, Zhang X. Hepatocellular Carcinoma. American Journal Of Clinical Pathology 2021, 157: 305-313. PMID: 34542582, DOI: 10.1093/ajcp/aqab125.Peer-Reviewed Original ResearchConceptsAnaplastic tumor cellsHepatocellular carcinomaNoncirrhotic liverVascular invasionHistologic patternCirrhotic liverTumor cellsClear cell subtypePathogenesis of HCCHigh histologic gradeLarger tumor sizeHigher tumor stageHigh tumor gradeHigh rateHepatitis BHepatitis CLiver diseaseTumor sizeHistologic gradeTumor stageTumor gradePathologic differencesHCC casesRetrospective analysisPathology archivesHNF-1β is a More Sensitive and Specific Marker Than C-Reactive Protein for Identifying Biliary Differentiation in Primary Hepatic Carcinomas.
Patil PA, Taddei T, Jain D, Zhang X. HNF-1β is a More Sensitive and Specific Marker Than C-Reactive Protein for Identifying Biliary Differentiation in Primary Hepatic Carcinomas. Archives Of Pathology & Laboratory Medicine 2021, 146: 220-226. PMID: 34086854, DOI: 10.5858/arpa.2020-0725-oa.Peer-Reviewed Original ResearchCan primary hepatocellular carcinoma histomorphology predict extrahepatic metastasis?
Kumar D, Hafez O, Jain D, Zhang X. Can primary hepatocellular carcinoma histomorphology predict extrahepatic metastasis? Human Pathology 2021, 113: 39-46. PMID: 33905775, DOI: 10.1016/j.humpath.2021.04.008.Peer-Reviewed Original ResearchConceptsMetastatic hepatocellular carcinomaHepatocellular carcinomaHistologic patternHistomorphologic featuresPrimary tumorMetastatic tumorsMacrotrabecular-massive hepatocellular carcinomaCommon histologic patternPathogenesis of metastasisSignificant intratumoral heterogeneityExtrahepatic metastasesLymph nodesMicrovascular invasionAdrenal glandCommon subtypeNoncirrhotic liverCirrhotic liverCommon siteMetastatic tissuesLarge cohortAbdominal cavityHCC subtypesPathology archivesMetastasisHCC metastasisα-Fetoprotein mRNA in situ hybridisation is a highly specific marker of hepatocellular carcinoma: a multi-centre study
Lu SX, Huang YH, Liu LL, Zhang CZ, Yang X, Yang YZ, Shao CK, Li JM, Xie D, Zhang X, Jain D, Yun JP. α-Fetoprotein mRNA in situ hybridisation is a highly specific marker of hepatocellular carcinoma: a multi-centre study. British Journal Of Cancer 2021, 124: 1988-1996. PMID: 33824478, PMCID: PMC8184895, DOI: 10.1038/s41416-021-01363-4.Peer-Reviewed Original ResearchConceptsHepatocellular carcinomaHepatocytic lesionsDiagnosis of HCCLiver biopsy cohortHepatocyte paraffin 1Independent retrospective cohortsBenign liver lesionsMulti-center studyGood diagnostic valueNovel diagnostic biomarkersArginase-1 (Arg-1) proteinsΑ-fetoprotein mRNASurgical cohortRetrospective cohortBiopsy cohortHepPar-1Arg-1Liver lesionsDiagnostic biomarkersDiagnostic valueMalignancy lesionsLesionsGlypican3CohortSpecific markers
2020
Hepatocellular neoplasms arising in genetic metabolic disorders: steatosis is common in both the tumor and background liver
Cheng L, Jain D, Kakar S, Torbenson MS, Wu TT, Yeh MM. Hepatocellular neoplasms arising in genetic metabolic disorders: steatosis is common in both the tumor and background liver. Human Pathology 2020, 108: 93-99. PMID: 33245984, DOI: 10.1016/j.humpath.2020.11.012.Peer-Reviewed Original ResearchConceptsGenetic metabolic disordersMetabolic disordersHepatocellular neoplasmsBackground liverType 1Ornithine carbamyl transferase deficiencyRare genetic metabolic disorderRare case reportBackground liver parenchymaGlycogen storage disease type 1Hereditary tyrosinemia type 1Disease type 1Tyrosinemia type 1Younger patientsRetrospective studyCase reportCommon findingLiver parenchymaSteatosisTransferase deficiencyPathological characterizationNeoplasmsTumorsDisordersPatientsLiver Pathologic Changes After Direct-Acting Antiviral Agent Therapy and Sustained Virologic Response in the Setting of Chronic Hepatitis C Virus Infection.
Celli R, Saffo S, Kamili S, Wiese N, Hayden T, Taddei T, Jain D. Liver Pathologic Changes After Direct-Acting Antiviral Agent Therapy and Sustained Virologic Response in the Setting of Chronic Hepatitis C Virus Infection. Archives Of Pathology & Laboratory Medicine 2020, 145: 419-427. PMID: 32810870, PMCID: PMC10960369, DOI: 10.5858/arpa.2020-0008-oa.Peer-Reviewed Original ResearchConceptsHepatocellular carcinomaHCC developmentChronic hepatitis C virus (HCV) infectionChronic viral hepatitis C infectionHepatitis C virus infectionViral hepatitis C infectionTissue polymerase chain reactionAntiviral agent therapyLiver histologic findingsLiver pathologic changesNon-SVR groupOccult HCV infectionPersistent liver inflammationSuccessful DAA therapyC virus infectionHepatitis C infectionSubset of patientsDegree of inflammationNumber of patientsPresence of virusDAA therapySVR patientsVirologic responseC infectionHCV infectionFibronodular hepatocellular carcinoma—a new variant of liver cancer: clinical, pathological and radiological correlation
Tefera J, Revzin M, Chapiro J, Savic L, Mulligan D, Batra R, Taddei T, Jain D, Zhang X. Fibronodular hepatocellular carcinoma—a new variant of liver cancer: clinical, pathological and radiological correlation. Journal Of Clinical Pathology 2020, 74: 31-35. PMID: 32430483, PMCID: PMC7674234, DOI: 10.1136/jclinpath-2020-206574.Peer-Reviewed Original ResearchConceptsAdvanced Barcelona Clinic Liver Cancer stageBarcelona Clinic Liver Cancer stageScirrhous HCCMultiple rounded nodulesNon-peripheral washoutLiver Cancer stageRadiological featuresClinical featuresRadiological correlationCarcinoma variantsCancer stageHCC casesHepatocellular carcinomaLiver cancerFibrotic liverConventional HCCHCCLower ratesHigh rateRounded nodulesProgressionDistinct patternsCarcinomaSpecific variantsLesions
2019
Macrotrabecular Hepatocellular Carcinoma
Jeon Y, Benedict M, Taddei T, Jain D, Zhang X. Macrotrabecular Hepatocellular Carcinoma. The American Journal Of Surgical Pathology 2019, 43: 943-948. PMID: 31135484, DOI: 10.1097/pas.0000000000001289.Peer-Reviewed Original ResearchMeSH KeywordsAgedAlpha-FetoproteinsCarcinoma, HepatocellularDisease ProgressionFemaleHepatectomyHepatitis BHepatitis CHumansLiver CirrhosisLiver NeoplasmsLiver TransplantationMaleMiddle AgedNeoplasm GradingNeoplasm Recurrence, LocalNeoplasm StagingProgression-Free SurvivalRetrospective StudiesRisk FactorsTime FactorsTumor BurdenConceptsHepatocellular carcinomaHCC subtypesHigh alpha-fetoprotein levelsWorse recurrence-free survivalDistinct HCC subtypeHepatitis C infectionRecurrence-free survivalAlpha-fetoprotein levelsAnaplastic tumor cellsHigh histologic gradePoor overall survivalConventional hepatocellular carcinomaHigh recurrence rateHigher AJCC stageDetailed pathologic evaluationMacrotrabecular patternC infectionPrimary resectionHepatitis BOverall survivalPathologic evaluationAJCC stageClinicopathologic featuresHistologic subtypeRecurrence rate
2018
A practical diagnostic approach to hepatic masses.
Vyas M, Jain D. A practical diagnostic approach to hepatic masses. Indian Journal Of Pathology And Microbiology 2018, 61: 2-17. PMID: 29567877, DOI: 10.4103/ijpm.ijpm_578_17.Peer-Reviewed Original ResearchConceptsDifferential diagnosisHepatic massCorrect diagnosisRight diagnosisBackground liver diseaseUnknown primary siteFocal nodular hyperplasiaHepatic mass lesionsPractical diagnostic approachList of antibodiesNonhepatocellular originProper workupClinical presentationHepatocellular originLiver diseaseHistologic featuresPrimary lesionClinicopathological correlationHepatic adenomaVascular tumorsMass lesionNonepithelial neoplasmsCommon siteNeedle biopsyNodular hyperplasia
2015
Comparison of 5 Immunohistochemical Markers of Hepatocellular Differentiation for the Diagnosis of Hepatocellular Carcinoma
Nguyen T, Phillips D, Jain D, Torbenson M, Wu TT, Yeh MM, Kakar S. Comparison of 5 Immunohistochemical Markers of Hepatocellular Differentiation for the Diagnosis of Hepatocellular Carcinoma. Archives Of Pathology & Laboratory Medicine 2015, 139: 1028-34. PMID: 26230595, DOI: 10.5858/arpa.2014-0479-oa.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkers, TumorCarcinoma, HepatocellularCell DifferentiationFemaleHumansImmunohistochemistryLiver NeoplasmsMaleMiddle AgedSensitivity and SpecificityConceptsHep Par 1Polyclonal carcinoembryonic antigenArginase-1Hepatocellular carcinomaGlypican-3Carcinoembryonic antigenPAR-1Immunohistochemical markersSensitive markerHepatocellular differentiationLiver biopsyCarcinomaBest overall sensitivityHepatocellular markersLimited tissueAntigen 1Overall sensitivityDiagnosisCombined useReliable diagnosisPositive resultsMarkersLimited role
2013
Immunohistochemical pitfalls and the importance of glypican 3 and arginase in the diagnosis of scirrhous hepatocellular carcinoma
Krings G, Ramachandran R, Jain D, Wu TT, Yeh MM, Torbenson M, Kakar S. Immunohistochemical pitfalls and the importance of glypican 3 and arginase in the diagnosis of scirrhous hepatocellular carcinoma. Modern Pathology 2013, 26: 782-791. PMID: 23348905, DOI: 10.1038/modpathol.2012.243.Peer-Reviewed Original ResearchMeSH KeywordsAdenocarcinoma, ScirrhousAdultAgedArginaseBile Duct NeoplasmsBile Ducts, IntrahepaticBiomarkers, TumorCarcinoma, HepatocellularChi-Square DistributionCholangiocarcinomaDiagnosis, DifferentialDiagnostic ErrorsFemaleGlypicansHumansImmunohistochemistryLiver NeoplasmsMaleMiddle AgedPredictive Value of TestsReproducibility of ResultsConceptsScirrhous hepatocellular carcinomaClassical hepatocellular carcinomaHepatocellular carcinomaHepatocellular carcinoma casesGlypican-3Carcinoma casesMarked stromal fibrosisEpithelial cell adhesion moleculeMetastatic adenocarcinomaIntrahepatic cholangiocarcinomaStromal fibrosisCytokeratin 7Needle biopsyFrequent positivityCell adhesion moleculeHepPar-1Immunohistochemical pitfallsMorphological subtypesCarcinomaAdenocarcinomaHepatocellular differentiationCytokeratin 19Erroneous diagnosisReliable markerAdhesion molecules
2012
Reticulin Loss in Benign Fatty Liver
Singhi AD, Jain D, Kakar S, Wu TT, Yeh MM, Torbenson M. Reticulin Loss in Benign Fatty Liver. The American Journal Of Surgical Pathology 2012, 36: 710-715. PMID: 22498821, DOI: 10.1097/pas.0b013e3182495c73.Peer-Reviewed Original ResearchMeSH KeywordsAdenomaAdolescentAdultAgedBiomarkersBiopsyCarcinoma, HepatocellularChildDiagnosis, DifferentialFatty LiverFemaleHumansLiverLiver NeoplasmsMaleMiddle AgedReticulinYoung AdultConceptsLoss of reticulinFatty changeHepatic adenomaHepatocellular carcinomaReticulin stainingDiagnostic pitfallsImportant diagnostic pitfallMarked steatosisModerate steatosisNonalcoholic steatohepatitisMild steatosisFibrosis stageReticulin stainNumber of fociLiver tissueBenign fatty liverCases of steatohepatitisDegree of steatosisDegree of inflammationNon-neoplastic liver tissueAmount of steatosisMarked fatty changeCases of steatosisFine needle aspiratesFatty liver
2009
Chromosomal abnormalities determined by comparative genomic hybridization are helpful in the diagnosis of atypical hepatocellular neoplasms
Kakar S, Chen X, Ho C, Burgart LJ, Adeyi O, Jain D, Sahai V, Ferrell LD. Chromosomal abnormalities determined by comparative genomic hybridization are helpful in the diagnosis of atypical hepatocellular neoplasms. Histopathology 2009, 55: 197-205. PMID: 19694827, PMCID: PMC3727398, DOI: 10.1111/j.1365-2559.2009.03343.x.Peer-Reviewed Original ResearchMeSH KeywordsAdenoma, Liver CellAge DistributionAge FactorsCarcinoma, HepatocellularChromosome AberrationsComparative Genomic HybridizationFemaleHumansLiver NeoplasmsMaleSex Factors