2019
Immunohistochemical and molecular features of cholangiolocellular carcinoma are similar to well-differentiated intrahepatic cholangiocarcinoma
Balitzer D, Joseph NM, Ferrell L, Shafizadeh N, Jain D, Zhang X, Yeh M, di Tommaso L, Kakar S. Immunohistochemical and molecular features of cholangiolocellular carcinoma are similar to well-differentiated intrahepatic cholangiocarcinoma. Modern Pathology 2019, 32: 1486-1494. PMID: 31186529, DOI: 10.1038/s41379-019-0290-0.Peer-Reviewed Original ResearchConceptsCholangiolocellular carcinomaIntrahepatic cholangiocarcinomaLow-grade cytologic atypiaPrimary liver carcinomaCapture-based next-generation sequencingCanals of HeringNumber alterationsHistologic subtypeCarcinoma componentCytologic atypiaImmunohistochemistry resultsCholangiocarcinomaLiver carcinomaCarcinomaSelect intronsCell subtypesStem cell subtypesHepatocellular componentDistinct entityMutational profileSubtypesNext-generation sequencingCD56Genomic profilesCD117
2012
PDX-1, CDX-2, TTF-1, and CK7
Chan ES, Alexander J, Swanson PE, Jain D, Yeh MM. PDX-1, CDX-2, TTF-1, and CK7. The American Journal Of Surgical Pathology 2012, 36: 737-743. PMID: 22498824, DOI: 10.1097/pas.0b013e31824aba59.Peer-Reviewed Original ResearchMeSH KeywordsAdultAgedAged, 80 and overBiomarkers, TumorCDX2 Transcription FactorDiagnosis, DifferentialDNA-Binding ProteinsFemaleHomeodomain ProteinsHumansImmunohistochemistryIntestinal NeoplasmsKeratin-20Keratin-7Liver NeoplasmsLung NeoplasmsMaleMiddle AgedNeuroendocrine TumorsPancreatic NeoplasmsSensitivity and SpecificitySingle-Blind MethodTrans-ActivatorsTranscription FactorsConceptsGI neuroendocrine tumorsThyroid transcription factor-1Pancreatic neuroendocrine tumorsBronchopulmonary neuroendocrine tumorsMetastatic neuroendocrine tumorsPrimary neuroendocrine tumorNeuroendocrine tumorsCDX-2PDX-1Primary siteMetastatic pancreatic neuroendocrine tumorsPrimary pancreatic neuroendocrine tumorsDuodenal neuroendocrine tumorsΒ-cell functionSimilar morphologic featuresPancreatic duodenal homeobox-1Good overall diagnostic accuracyOverall diagnostic accuracyDuodenal homeobox 1Radiologic dataTranscription factor 1IHC panelImmunohistochemical markersIHC analysisKeratin 7