2022
An Expert, Multidisciplinary Perspective on Best Practices in Biomarker Testing in Intrahepatic Cholangiocarcinoma
Madoff DC, Abi-Jaoudeh N, Braxton D, Goyal L, Jain D, Odisio BC, Salem R, Schattner M, Sheth R, Li D. An Expert, Multidisciplinary Perspective on Best Practices in Biomarker Testing in Intrahepatic Cholangiocarcinoma. The Oncologist 2022, 27: 884-891. PMID: 35925597, PMCID: PMC9526481, DOI: 10.1093/oncolo/oyac139.Peer-Reviewed Original ResearchConceptsIntrahepatic cholangiocarcinomaBiomarker testingMultidisciplinary teamImage-guided liver biopsyMetastatic intrahepatic cholangiocarcinomaEvidence-based guidelinesIntrahepatic biliary treeNext-generation sequencingActionable genetic alterationsTreatment landscapeLiver biopsyMedical oncologistsInterventional oncologistsPoor prognosisAggressive malignancyBiliary treeTissue acquisitionBiopsy methodImaging modalitiesDesmoplastic natureGenetic alterationsTissue collectionNeedle choicePrecision medicineCholangiocarcinoma
2020
Updates in staging and pathologic evaluation of esophageal carcinoma following neoadjuvant therapy
Zhang X, Jain D. Updates in staging and pathologic evaluation of esophageal carcinoma following neoadjuvant therapy. Annals Of The New York Academy Of Sciences 2020, 1482: 163-176. PMID: 32892349, DOI: 10.1111/nyas.14462.Peer-Reviewed Original ResearchConceptsNeoadjuvant therapyEsophageal cancerEsophageal carcinomaRecent American Joint CommitteePreoperative neoadjuvant therapyThorough pathologic assessmentTumor regression gradingAdvanced esophageal carcinomaAmerican Joint CommitteeCancer (AJCC) staging systemTumor regression gradeAccurate tumor stagingValuable prognostic informationRegression gradingSurgical resectionLymph nodesPathologic assessmentRegression gradeHistologic typePathologic evaluationResidual tumorPoor prognosisCell carcinomaGastrointestinal carcinomasStaging systemType 3 Inositol 1,4,5‐Trisphosphate Receptor Is Increased and Enhances Malignant Properties in Cholangiocarcinoma
Ueasilamongkol P, Khamphaya T, Guerra MT, Rodrigues M, Gomes DA, Kong Y, Wei W, Jain D, Trampert DC, Ananthanarayanan M, Banales JM, Roberts LR, Farshidfar F, Nathanson MH, Weerachayaphorn J. Type 3 Inositol 1,4,5‐Trisphosphate Receptor Is Increased and Enhances Malignant Properties in Cholangiocarcinoma. Hepatology 2020, 71: 583-599. PMID: 31251815, PMCID: PMC6934938, DOI: 10.1002/hep.30839.Peer-Reviewed Original ResearchConceptsType 3 inositolCCA cellsIntracellular calcium ionsPathogenesis of malignanciesCCA cell linesCommon malignancyPoor prognosisTrisphosphate receptorMalignant featuresMitochondrial CaITPR3 expressionCholangiocarcinomaRegions of ERMalignant propertiesCCA samplesCell proliferationCholangiocytesEndoplasmic reticulumType of tissueMalignancyCell linesITPR3PathogenesisCell deathCell migration
2010
Malignant tumours of gallbladder and extrahepatic bile ducts
Flood T, Jain D, Marginean E. Malignant tumours of gallbladder and extrahepatic bile ducts. Diagnostic Histopathology 2010, 16: 360-370. DOI: 10.1016/j.mpdhp.2010.06.003.Peer-Reviewed Original ResearchExtrahepatic bile duct cancerExtrahepatic bile ductBile ductGallbladder cancerBiliary tract neoplasmsBile duct cancerStage of diseaseUseful prognostic indicatorManagement of cancerDuct cancerOlder patientsAggressive courseFavorable prognosisClinical presentationHistologic typePancreaticobiliary typeChronic inflammationHistologic featuresPoor prognosisHistologic gradePrognostic indicatorGeographic predilectionHistologic variantsBiliary epitheliumMalignant tumors