2011
Enhancing alloreactivity does not restore GVHD induction but augments skin graft rejection by CD4+ effector memory T cells
Anderson BE, Tang AL, Wang Y, Froicu M, Rothstein D, McNiff JM, Jain D, Demetris AJ, Farber DL, Shlomchik WD, Shlomchik MJ. Enhancing alloreactivity does not restore GVHD induction but augments skin graft rejection by CD4+ effector memory T cells. European Journal Of Immunology 2011, 41: 2782-2792. PMID: 21660940, PMCID: PMC3517133, DOI: 10.1002/eji.201141678.Peer-Reviewed Original ResearchMeSH KeywordsAdoptive TransferAnimalsCD4-Positive T-LymphocytesDisease Models, AnimalGenes, T-Cell ReceptorGraft RejectionGraft vs Host DiseaseHematopoietic Stem Cell TransplantationHumansImmunologic MemoryIsoantigensLymphocyte ActivationMicePostoperative ComplicationsSkin TransplantationT-Cell Antigen Receptor SpecificityT-Lymphocyte SubsetsConceptsEffector memory T cellsMemory T cellsSkin graft rejectionLymphopenia-induced proliferationT cellsMild GVHDAlloreactive clonesGraft rejectionAllogeneic hematopoietic stem cell transplantationHematopoietic stem cell transplantationT cell receptor repertoireGVHD effector cellsDonor T cellsStem cell transplantationDiverse T cell receptor repertoireNaive T cellsRapid skin graft rejectionAlloreactive repertoireGVHD inductionLimited GVHDHost diseaseLeukemia effectEffector cellsCell transplantationSyngeneic recipients
2009
Central Memory CD8+ T Cells Induce Graft-versus-Host Disease and Mediate Graft-versus-Leukemia
Zheng H, Matte-Martone C, Jain D, McNiff J, Shlomchik WD. Central Memory CD8+ T Cells Induce Graft-versus-Host Disease and Mediate Graft-versus-Leukemia. The Journal Of Immunology 2009, 182: 5938-5948. PMID: 19414745, PMCID: PMC9844260, DOI: 10.4049/jimmunol.0802212.Peer-Reviewed Original ResearchConceptsMemory T cellsT cellsHost diseaseAllogeneic hemopoietic stem cell transplantationChronic phase chronic myelogenous leukemiaFunctional T-cell memoryMultiple minor histocompatibility AgsBALB/c recipientsEffector memory T cellsHemopoietic stem cell transplantationCentral memory T cellsNonmalignant host tissuesCentral memory CD8Donor T cellsMinor histocompatibility AgT-cell reconstitutionStem cell transplantationT cell memoryNaive T cellsAlphabeta T cellsChronic myelogenous leukemiaC recipientsClinical GVHDHistological diseaseLeukemia effect
2008
Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells
Anderson BE, Taylor PA, McNiff JM, Jain D, Demetris AJ, Panoskaltsis-Mortari A, Ager A, Blazar BR, Shlomchik WD, Shlomchik MJ. Effects of donor T-cell trafficking and priming site on graft-versus-host disease induction by naive and memory phenotype CD4 T cells. Blood 2008, 111: 5242-5251. PMID: 18285547, PMCID: PMC2384145, DOI: 10.1182/blood-2007-09-107953.Peer-Reviewed Original ResearchConceptsSecondary lymphoid tissuesT cellsMemory phenotype CD4 T cellsEffector memory T cellsAllogeneic stem cell transplantationHost disease inductionCD4 T cellsMemory T cellsStem cell transplantationNaive T cellsT cell traffickingGVHD initiationMild GVHDHost diseaseTransplant recipientsTumor effectCell transplantationLymphoid tissueGVHDDisease inductionImmune responseCD62LCCR7Major causeGraft
2007
Effector memory CD4+ T cells mediate graft-versus-leukemia without inducing graft-versus-host disease
Zheng H, Matte-Martone C, Li H, Anderson BE, Venketesan S, Tan H, Jain D, McNiff J, Shlomchik WD. Effector memory CD4+ T cells mediate graft-versus-leukemia without inducing graft-versus-host disease. Blood 2007, 111: 2476-2484. PMID: 18045967, PMCID: PMC2234071, DOI: 10.1182/blood-2007-08-109678.Peer-Reviewed Original ResearchMeSH KeywordsAnimalsBone Marrow TransplantationCD4-Positive T-LymphocytesGraft vs Host DiseaseGraft vs Leukemia EffectHematopoietic Stem Cell TransplantationHistocompatibility TestingImmunologic MemoryLeukemia, Myelogenous, Chronic, BCR-ABL PositiveLymphocyte TransfusionMajor Histocompatibility ComplexMiceTransplantation, HomologousConceptsDonor T cellsT cellsHost diseaseAllogeneic hematopoietic stem cell transplantationFunctional T-cell memoryPerforin-deficient T cellsT-cell-depleted allograftsEffector memory T cellsHematopoietic stem cell transplantationDirect cytolytic functionNonmalignant host tissuesEffector memory CD4Memory T cellsStem cell transplantationT cell memoryBlast crisis chronic myelogenous leukemiaRelevant mouse modelChronic myelogenous leukemiaApplicable cell therapyRecipient alloantigensImmune reconstitutionLeukemia effectMemory CD4Chronic phaseCell transplantation
2005
CD8+ Central Memory T Cells Mediate Graft-Versus-Host Disease Although Retain Graft-Versus-Leukemia Effect.
Zheng H, Matte C, Anderson B, Venkatesan S, Jain D, Shlomchik M, Shlomchik W. CD8+ Central Memory T Cells Mediate Graft-Versus-Host Disease Although Retain Graft-Versus-Leukemia Effect. Blood 2005, 106: 1312. DOI: 10.1182/blood.v106.11.1312.1312.Peer-Reviewed Original ResearchCD8 cellsMemory T cellsMore weight lossCell recipientsT cellsCM cellsWeight lossGraft-VersusHistologic GVHDLess weight lossEffector functionsBALB/c recipientsEffector memory T cellsCentral memory T cellsDay 16Central memory TClear histologic evidencePeriportal inflammatory infiltrationReconstitution of immunityDonor T cellsTime pointsMost time pointsDonor BMEarly time pointsEffective GVL