2024
Modeling seizure networks in neuron-glia cultures using microelectrode arrays
Boddeti U, Langbein J, McAfee D, Altshuler M, Bachani M, Zaveri H, Spencer D, Zaghloul K, Ksendzovsky A. Modeling seizure networks in neuron-glia cultures using microelectrode arrays. Frontiers In Network Physiology 2024, 4: 1441345. PMID: 39290793, PMCID: PMC11405204, DOI: 10.3389/fnetp.2024.1441345.Peer-Reviewed Original ResearchNetwork changesSeizure networkSeizure modelsDays of chronic treatmentDimensionality reductionNetwork developmentDrug-resistant epilepsyNeuron-glia culturesMean firing rateNetworkTreatment failureChronic treatmentMicroelectrode arraysResection surgeryRetrospective studyFiring rateSeizuresExperience seizuresNeurological disordersSystematic 1 Hz direct electrical stimulation for seizure induction: A reliable method for localizing seizure onset zone and predicting seizure freedom
Sivaraju A, Quraishi I, Collins E, McGrath H, Ramos A, Turk-Browne N, Zaveri H, Damisah E, Spencer D, Hirsch L. Systematic 1 Hz direct electrical stimulation for seizure induction: A reliable method for localizing seizure onset zone and predicting seizure freedom. Brain Stimulation 2024, 17: 339-345. PMID: 38490472, DOI: 10.1016/j.brs.2024.03.011.Peer-Reviewed Original ResearchSeizure inductionSeizure onset zoneSurgical outcomesHabitual seizuresOnset zonePredicting seizure freedomExcellent surgical outcomesProspective cohort studyMann-Whitney testConsecutive patientsFisher's exactSeizure freedomRefractory epilepsyCohort studyPost-surgeryInsular regionsMann-WhitneyPatientsIntracranial EEGSeizuresLocalizing seizure onset zonesStimulationElectrical stimulationMedial temporal regionsTemporal regions
2006
Differential Glutamate Dehydrogenase (GDH) Activity Profile in Patients with Temporal Lobe Epilepsy
Malthankar‐Phatak G, De Lanerolle N, Eid T, Spencer DD, Behar KL, Spencer SS, Kim JH, Lai JC. Differential Glutamate Dehydrogenase (GDH) Activity Profile in Patients with Temporal Lobe Epilepsy. Epilepsia 2006, 47: 1292-1299. PMID: 16922873, DOI: 10.1111/j.1528-1167.2006.00543.x.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyLobe epilepsyMTLE groupLesion-associated temporal lobe epilepsyIntractable epilepsy patientsEnergy metabolismExcitotoxic effectsPathophysiologic mechanismsPatient groupIntractable seizuresHippocampal tissueMetabolism of glutamateEpilepsy patientsNeurotransmitter metabolismTemporal cortexEpilepsyHippocampusMetabolic statusCortexSignificant alterationsLDH activityPatientsMTLESeizuresGDH activity
1984
Intracerebral masses in patients with intractable partial epilepsy.
Spencer D, Spencer S, Mattson R, Williamson P. Intracerebral masses in patients with intractable partial epilepsy. Neurology 1984, 34: 432-6. PMID: 6422323, DOI: 10.1212/wnl.34.4.432.Peer-Reviewed Original ResearchConceptsPartial seizuresSubtotal lobectomyUncontrolled partial seizuresGood seizure controlIntractable partial epilepsySimple partial seizuresIntracranial mass lesionsForm of treatmentSeizure controlMass resectionNeurologic examinationPreoperative evaluationSurgical treatmentIntracerebral massPartial epilepsyRadiologic studiesMass lesionStructural lesionsPatientsSeizuresLesionsLobectomyNeoplasmsTreatmentResection
1983
Sexual automatisms in complex partial seizures.
Spencer S, Spencer D, Williamson P, Mattson R. Sexual automatisms in complex partial seizures. Neurology 1983, 33: 527-33. PMID: 6682492, DOI: 10.1212/wnl.33.5.527.Peer-Reviewed Original ResearchConceptsComplex partial seizuresSexual automatismsPartial seizuresRefractory complex partial seizuresTemporal lobe diseaseFrontal lobe pathologySeizure frequencyFrontal lobectomySeizure focusSeizure originCalcified lesionsPatientsPelvic thrustingFrontal lobeSeizuresDepth EEGMasturbatory activityAutomatismsLobectomyLesionsDiseasePathology