2024
Stability of infraslow correlation structure in time-shifted intracranial EEG signals
Joshi R, Duckrow R, Goncharova I, Hirsch L, Spencer D, Godwin D, Zaveri H. Stability of infraslow correlation structure in time-shifted intracranial EEG signals. Frontiers In Network Physiology 2024, 4: 1441294. PMID: 39258030, PMCID: PMC11384574, DOI: 10.3389/fnetp.2024.1441294.Peer-Reviewed Original ResearchInfraslow activityContact pairsFrequency bandMagnitude-squared coherenceAntiseizure medicationsMedically refractory epilepsy patientsElectrode contact pairsHigher-frequency activityRefractory epilepsy patientsDC-coupled recordingsIcEEG epochsEEG frequency bandsEnvelope correlationOptimal parametersClinical relevanceSeizure riskIntracranial EEGEpilepsy patientsPatientsIntracranial EEG signalsTaperTraditional EEG frequency bandsSystematic 1 Hz direct electrical stimulation for seizure induction: A reliable method for localizing seizure onset zone and predicting seizure freedom
Sivaraju A, Quraishi I, Collins E, McGrath H, Ramos A, Turk-Browne N, Zaveri H, Damisah E, Spencer D, Hirsch L. Systematic 1 Hz direct electrical stimulation for seizure induction: A reliable method for localizing seizure onset zone and predicting seizure freedom. Brain Stimulation 2024, 17: 339-345. PMID: 38490472, DOI: 10.1016/j.brs.2024.03.011.Peer-Reviewed Original ResearchSeizure inductionSeizure onset zoneSurgical outcomesHabitual seizuresOnset zonePredicting seizure freedomExcellent surgical outcomesProspective cohort studyMann-Whitney testConsecutive patientsFisher's exactSeizure freedomRefractory epilepsyCohort studyPost-surgeryInsular regionsMann-WhitneyPatientsIntracranial EEGSeizuresLocalizing seizure onset zonesStimulationElectrical stimulationMedial temporal regionsTemporal regions
2017
Long-term Postoperative Outcomes in Patients with Focal Cortical Dysplasia: Predictive Factors and AED Withdrawal (P4.107)
Farooque P, Stanford E, Rechnitzer A, Bandt K, Bonito J, Spencer D, Hirsch L. Long-term Postoperative Outcomes in Patients with Focal Cortical Dysplasia: Predictive Factors and AED Withdrawal (P4.107). Neurology 2017, 88 DOI: 10.1212/wnl.88.16_supplement.p4.107.Peer-Reviewed Original Research
2006
Increased expression of phosphate-activated glutaminase in hippocampal neurons in human mesial temporal lobe epilepsy
Eid T, Hammer J, Rundén-Pran E, Roberg B, Thomas MJ, Osen K, Davanger S, Laake P, Torgner IA, Lee TS, Kim JH, Spencer DD, Ottersen OP, de Lanerolle NC. Increased expression of phosphate-activated glutaminase in hippocampal neurons in human mesial temporal lobe epilepsy. Acta Neuropathologica 2006, 113: 137-152. PMID: 17115168, DOI: 10.1007/s00401-006-0158-5.Peer-Reviewed Original ResearchConceptsMesial temporal lobe epilepsyTemporal lobe epilepsyPhosphate-activated glutaminaseLobe epilepsyHippocampal formationHuman mesial temporal lobe epilepsyWestern blotElevation of glutamateNon-epileptogenic hippocampusElevated glutamate levelsDouble-labeling experimentsRecurrent seizuresDentate gyrusPolymorphic layerExtracellular glutamateGlutamate levelsHippocampal homogenatesGlutamate homeostasisHippocampal neuronsBasal concentrationsPAG immunoreactivityPatientsNeuronsNumber of neuronsEpilepsyDifferential Glutamate Dehydrogenase (GDH) Activity Profile in Patients with Temporal Lobe Epilepsy
Malthankar‐Phatak G, De Lanerolle N, Eid T, Spencer DD, Behar KL, Spencer SS, Kim JH, Lai JC. Differential Glutamate Dehydrogenase (GDH) Activity Profile in Patients with Temporal Lobe Epilepsy. Epilepsia 2006, 47: 1292-1299. PMID: 16922873, DOI: 10.1111/j.1528-1167.2006.00543.x.Peer-Reviewed Original ResearchConceptsTemporal lobe epilepsyLobe epilepsyMTLE groupLesion-associated temporal lobe epilepsyIntractable epilepsy patientsEnergy metabolismExcitotoxic effectsPathophysiologic mechanismsPatient groupIntractable seizuresHippocampal tissueMetabolism of glutamateEpilepsy patientsNeurotransmitter metabolismTemporal cortexEpilepsyHippocampusMetabolic statusCortexSignificant alterationsLDH activityPatientsMTLESeizuresGDH activity
1985
Interhemispheric commissurotomy for congenital hemiplegics with intractable epilepsy.
Goodman R, Williamson P, Reeves A, Spencer S, Spencer D, Mattson R, Roberts D. Interhemispheric commissurotomy for congenital hemiplegics with intractable epilepsy. Neurology 1985, 35: 1351-4. PMID: 4022384, DOI: 10.1212/wnl.35.9.1351.Peer-Reviewed Original Research
1984
Intracerebral masses in patients with intractable partial epilepsy.
Spencer D, Spencer S, Mattson R, Williamson P. Intracerebral masses in patients with intractable partial epilepsy. Neurology 1984, 34: 432-6. PMID: 6422323, DOI: 10.1212/wnl.34.4.432.Peer-Reviewed Original ResearchConceptsPartial seizuresSubtotal lobectomyUncontrolled partial seizuresGood seizure controlIntractable partial epilepsySimple partial seizuresIntracranial mass lesionsForm of treatmentSeizure controlMass resectionNeurologic examinationPreoperative evaluationSurgical treatmentIntracerebral massPartial epilepsyRadiologic studiesMass lesionStructural lesionsPatientsSeizuresLesionsLobectomyNeoplasmsTreatmentResection
1983
Sexual automatisms in complex partial seizures.
Spencer S, Spencer D, Williamson P, Mattson R. Sexual automatisms in complex partial seizures. Neurology 1983, 33: 527-33. PMID: 6682492, DOI: 10.1212/wnl.33.5.527.Peer-Reviewed Original ResearchConceptsComplex partial seizuresSexual automatismsPartial seizuresRefractory complex partial seizuresTemporal lobe diseaseFrontal lobe pathologySeizure frequencyFrontal lobectomySeizure focusSeizure originCalcified lesionsPatientsPelvic thrustingFrontal lobeSeizuresDepth EEGMasturbatory activityAutomatismsLobectomyLesionsDiseasePathology