2024
Preclinical Evidence of the Effects of Sweet Flavors: Sweetness Increases Nicotine Intake and Seeking
Bagdas D, Addy N. Preclinical Evidence of the Effects of Sweet Flavors: Sweetness Increases Nicotine Intake and Seeking. Nicotine & Tobacco Research 2024, ntae241. PMID: 39413033, DOI: 10.1093/ntr/ntae241.Peer-Reviewed Original ResearchNicotine use behaviorsNicotine reinforcementNicotine intakeSelf-administrationNicotine useFlavor exposureUse behaviorsIntravenous nicotine self-administrationPattern of nicotine intakeSessions of self-administrationNicotine self-administrationIncreased nicotine intakeNicotine-related behaviorsSaccharin-flavored solutionInfluence of early exposureSeeking behaviorNo significant sex differencesSignificant sex differencesImpact of early exposureSaccharin exposureEarly exposureFlavored solutionNicotine addictionSex differencesNicotine
2022
Persistent sensory changes and sex differences in transgenic mice conditionally expressing HIV-1 Tat regulatory protein
Toma W, Paris J, Warncke U, Nass S, Caillaud M, McKiver B, Ondo O, Bagdas D, Bigbee J, Knapp P, Hauser K, Damaj M. Persistent sensory changes and sex differences in transgenic mice conditionally expressing HIV-1 Tat regulatory protein. Experimental Neurology 2022, 358: 114226. PMID: 36096180, PMCID: PMC10053560, DOI: 10.1016/j.expneurol.2022.114226.Peer-Reviewed Original ResearchConceptsSensory neuropathyFemale miceHIV-1Tat expressionSensory nerve action potentialsIntraepidermal nerve fiber densityChronic HIV-1Persistent sensory changesPain-like behaviorsPeripheral sensory neuropathySevere chronic painDevelopment of neuropathyNerve fiber densityLumbar spinal cordDevelopment of hypersensitivityNerve action potentialsPrevious preclinical studiesDorsal root gangliaTNF-α expressionPPAR-α gene expressionTat regulatory proteinRole of TatHIV-1 TatSex differencesAllodynic responses
2020
Conditional expression of HIV‐1 tat in the mouse alters the onset and progression of tonic, inflammatory and neuropathic hypersensitivity in a sex‐dependent manner
Bagdas D, Paris J, Carper M, Wodarski R, Rice A, Knapp P, Hauser K, Damaj M. Conditional expression of HIV‐1 tat in the mouse alters the onset and progression of tonic, inflammatory and neuropathic hypersensitivity in a sex‐dependent manner. European Journal Of Pain 2020, 24: 1609-1623. PMID: 32533878, PMCID: PMC7856573, DOI: 10.1002/ejp.1618.Peer-Reviewed Original ResearchConceptsHIV-1 TatSex-dependent mannerFemale miceMechanical hypersensitivityAdjuvant injectionThermal hypersensitivityNeurotoxic HIV-1 regulatory proteinComplete Freund's adjuvant injectionChronic constrictive nerve injuryHIV sensory neuropathyNeuropathic nociceptive behaviorMagnitude of inflammationFreund's adjuvant injectionPeripheral nervous systemHIV-1 regulatory proteinHIV-1 proteinsAbility of TatSex differencesSequel of eventsNeuropathic hypersensitivityTat miceNerve injuryFormalin injectionPeripheral neuropathySensory neuropathy
2016
Sex Differences and Drug Dose Influence the Role of the α7 Nicotinic Acetylcholine Receptor in the Mouse Dextran Sodium Sulfate-Induced Colitis Model
AlSharari S, Bagdas D, Akbarali H, Lichtman P, Raborn E, Cabral G, Carroll F, McGee E, Damaj M. Sex Differences and Drug Dose Influence the Role of the α7 Nicotinic Acetylcholine Receptor in the Mouse Dextran Sodium Sulfate-Induced Colitis Model. Nicotine & Tobacco Research 2016, 19: 460-468. PMID: 27639096, PMCID: PMC6894014, DOI: 10.1093/ntr/ntw245.Peer-Reviewed Original ResearchConceptsΑ7 nicotinic acetylcholine receptorWild-type miceColitis severityNicotinic acetylcholine receptorsFemale miceHigher tumor necrosis factor-alpha levelsAcetylcholine receptorsTumor necrosis factor-alpha levelsNecrosis factor-alpha levelsLittermate wild-type miceAnti-colitis activityAnti-colitis effectΑ7 knockout miceDextran sodium sulfatePathogenesis of colitisAnti-inflammatory effectsFemale adult miceViable therapeutic approachSeverity of diseaseSex differencesColon lengthDisease activityColonic levelsColitis modelUlcerative colitis
2015
Sex Differences and Drug Dose Influence the Role of the α-7 Nicotinic Acetylcholine Receptor in the Mouse Dextran Sodium Sulfate-Induced Colitis Model
AlSharari S, Bagdas D, Akbarali H, Cabral G, Carroll I, Damaj I, Lichtman P. Sex Differences and Drug Dose Influence the Role of the α-7 Nicotinic Acetylcholine Receptor in the Mouse Dextran Sodium Sulfate-Induced Colitis Model. The American Journal Of Gastroenterology 2015, 110: s776. DOI: 10.14309/00000434-201510001-01826.Peer-Reviewed Original Research