2022
Amygdala–prefrontal connectivity in children with maladaptive aggression is modulated by social impairment
Ibrahim K, Kalvin C, Morand-Beaulieu S, He G, Pelphrey KA, McCarthy G, Sukhodolsky DG. Amygdala–prefrontal connectivity in children with maladaptive aggression is modulated by social impairment. Cerebral Cortex 2022, 32: 4371-4385. PMID: 35059702, PMCID: PMC9574236, DOI: 10.1093/cercor/bhab489.Peer-Reviewed Original ResearchConceptsSocial impairmentPrefrontal cortexEmotion processingMaladaptive aggressionAggressive behaviorSocial deficitsEmotion perception taskImplicit emotion processingFace emotion processingFunctional magnetic resonance imagingGreater social impairmentAmygdala-prefrontal connectivityChildhood-onset psychiatric disordersVentral prefrontal cortexDorsolateral prefrontal cortexFearful facesSocial cognitionPerception taskCalm facesSocial cuesTransdiagnostic sampleAmygdala reactivityParent ratingsPFC connectivityDiminished connectivity
2021
Large-scale functional brain networks of maladaptive childhood aggression identified by connectome-based predictive modeling
Ibrahim K, Noble S, He G, Lacadie C, Crowley MJ, McCarthy G, Scheinost D, Sukhodolsky DG. Large-scale functional brain networks of maladaptive childhood aggression identified by connectome-based predictive modeling. Molecular Psychiatry 2021, 27: 985-999. PMID: 34690348, PMCID: PMC9035467, DOI: 10.1038/s41380-021-01317-5.Peer-Reviewed Original ResearchConceptsLarge-scale functional networksChildhood aggressionSeverity of aggressionIndividual differencesBrain networksAdolescent Brain Cognitive Development (ABCD) studyConnectome-based predictive modelingReactive-Proactive Aggression QuestionnaireEmotion perception taskLarge-scale functional brain networksAssociation of connectivityFunctional networksCognitive Development StudyAggressive behaviorFunctional brain networksIndependent samplesCognitive controlEmotion regulationEmotion processingPerception taskCalm facesMaladaptive aggressionPsychiatric disordersTransdiagnostic sampleFrontoparietal network