2019
Using holographic illumination to study synaptic signal integration at individual dendritic spines
Weng J, Celis C, Zecevic D. Using holographic illumination to study synaptic signal integration at individual dendritic spines. 2019, 10865: 1086514. DOI: 10.1117/12.2507284.Peer-Reviewed Original ResearchSynaptic signal integrationExcitatory synaptic potentialsDendritic spinesSynaptic potentialsTemporal summationAcute cortical brain slicesIndividual synapsesLayer 5 pyramidal neuronsIndividual excitatory synapsesThin basal dendritesCortical brain slicesVoltage-sensitive dye recordingIndividual dendritic spinesSite of originSensory information processingBasal dendritesPyramidal neuronsExcitatory synapsesBrain slicesRepetitive activationVoltage-sensitive dyeSomatic recordingsSingle synapsesSynaptic signalsIndividual neurons
2011
Somatic Membrane Potential and Kv1 Channels Control Spike Repolarization in Cortical Axon Collaterals and Presynaptic Boutons
Foust AJ, Yu Y, Popovic M, Zecevic D, McCormick DA. Somatic Membrane Potential and Kv1 Channels Control Spike Repolarization in Cortical Axon Collaterals and Presynaptic Boutons. Journal Of Neuroscience 2011, 31: 15490-15498. PMID: 22031895, PMCID: PMC3225031, DOI: 10.1523/jneurosci.2752-11.2011.Peer-Reviewed Original ResearchMeSH Keywords4-AminopyridineAnimalsAxonsBiophysical PhenomenaComputer SimulationCrystallinsDose-Response Relationship, DrugElapid VenomsElectric StimulationFemaleGreen Fluorescent ProteinsIn Vitro TechniquesMaleMembrane PotentialsMiceMice, TransgenicModels, NeurologicalMu-CrystallinsNerve NetNeuronsPatch-Clamp TechniquesPotassium Channel BlockersPresynaptic TerminalsShaker Superfamily of Potassium ChannelsSomatosensory CortexStyrenesTetraethylammoniumConceptsAxon collateralsPresynaptic boutonsKv1 channelsSpike repolarizationPresynaptic terminalsSubthreshold depolarizationAction potentialsΑ-dendrotoxinLayer 5 pyramidal cellsIntracortical axon collateralsSynaptic neurotransmitter releaseMouse brain slicesSomatic membrane potentialKv1 subunitsPyramidal cellsSynaptic transmissionBrain slicesVoltage-sensitive dyeLow dosesNeurotransmitter releaseSynaptic strengthBoutonsCollateralsRepolarizationIon channels
2010
Imaging Inhibitory Synaptic Potentials Using Voltage Sensitive Dyes
Canepari M, Willadt S, Zecevic D, Vogt KE. Imaging Inhibitory Synaptic Potentials Using Voltage Sensitive Dyes. Biophysical Journal 2010, 98: 2032-2040. PMID: 20441768, PMCID: PMC2862202, DOI: 10.1016/j.bpj.2010.01.024.Peer-Reviewed Original ResearchConceptsInhibitory postsynaptic potentialsVoltage-sensitive dyeGABAergic inhibitory postsynaptic potentialsCA1 hippocampal pyramidal neuronsPatch electrodeInhibitory synaptic potentialsInhibitory synaptic transmissionHippocampal pyramidal neuronsIntracellular chloride concentrationWhole-cell configurationPyramidal neuronsApical dendritesPostsynaptic potentialsSynaptic potentialsSynaptic transmissionBrain slicesElectrode recordingsNeuronsSensitive dyeVoltage imaging techniqueDendritesMultiple sitesVoltage imagingAxons
1999
Fast Optical Recordings of Membrane Potential Changes From Dendrites of Pyramidal Neurons
Antic S, Major G, Zecevic D. Fast Optical Recordings of Membrane Potential Changes From Dendrites of Pyramidal Neurons. Journal Of Neurophysiology 1999, 82: 1615-1621. PMID: 10482775, DOI: 10.1152/jn.1999.82.3.1615.Peer-Reviewed Original ResearchConceptsBasolateral dendritesApical dendritesBrain slicesVoltage-sensitive dyeNeuronal processesPyramidal neuronsMembrane potential transientsPharmacological effectsSynaptic stimulationAction potentialsInvertebrate neuronsNeuronsPatch electrodeSingle neuronsElectrical activityMembrane potential changesFast optical recordingDistal processesVertebrate neuronsOptical recordingDendritesH incubation periodStimulationApical processesRecordings